| 28 Nov 20 | r00        | APRAPR | 2 - 1 | GOR MahiaGOR Mahia |
| 28 Nov 20 | r00        | Forest RangersForest Ranger | 0 - 0 | BouenguidiBouenguidi |
| 28 Nov 20 | r00        | VipersVipers | 0 - 1 | Al-Hilal OmdurmanAl-Hilal Omdu |
| 28 Nov 20 | r00        | Jwaneng GalaxyJwaneng Galax | 4 - 0 | ZilimadjouZilimadjou |
| 28 Nov 20 | r00        | Costa do SolCosta do Sol | 1 - 2 | FC PlatinumFC Platinum |
| 28 Nov 20 | r00        | Les Buffles du BorgouLes Buffles d | 1 - 1 | MC AlgerMC Alger |
| 28 Nov 20 | r00        | MlandegeMlandege | 0 - 5 | CS SfaxienCS Sfaxien |
| 28 Nov 20 | r00        | Al-Ahly BenghaziAl-Ahly Bengh | 0 - 0 | Mekelle 70 EndertaMekelle 70 En |
| 29 Nov 20 | r00        | Young BuffaloesYoung Buffalo | 0 - 0 | Le Messager NgoziLe Messager N |
| 29 Nov 20 | r00        | PWD BamendaPWD Bamenda | 0 - 1 | Kaizer ChiefsKaizer Chiefs |
| 29 Nov 20 | r00        | BantuBantu | 0 - 1 | NkanaNkana |
| 29 Nov 20 | r00        | AS OtohôAS Otohô | 1 - 1 | Al-MerrikhAl-Merrikh |
| 29 Nov 20 | r00        | AkonanguiAkonangui | 0 - 1 | Atlético PetróleosAtlético Petr |
| 29 Nov 20 | r00        | Plateau UnitedPlateau Unite | 0 - 1 | Simba SCSimba SC |
| 29 Nov 20 | r00        | GazelleGazelle | P - P | Garde Républicaine DjibouGarde Républi |
| 29 Nov 20 | r00        | CR BelouizdadCR Belouizdad | 2 - 0 | Al-Nasr SCSCAl-Nasr SCSC |
| 29 Nov 20 | r00        | RahimoRahimo | 0 - 1 | EnyimbaEnyimba |
| 29 Nov 20 | r00        | NouadhibouNouadhibou | 1 - 1 | Asante KotokoAsante Kotoko |
| 29 Nov 20 | r00        | AS SONIDEPAS SONIDEP | 2 - 0 | Mogadishu CityMogadishu Cit |
| 29 Nov 20 | r00        | RC AbidjanRC Abidjan | 1 - 0 | ASC KaraASC Kara |
| 29 Nov 20 | r00        | Ashanti Golden BoysAshanti Golde | 1 - 2 | Stade MalienStade Malien |
| 29 Nov 20 | r00        | Gambia Armed Forces FCGambia Armed | 1 - 1 | TeunguethTeungueth |
| 04 Dec 20 | r00        | Al-MerrikhAl-Merrikh | 2 - 0 | AS OtohôAS Otohô |
| 04 Dec 20 | r00        | Garde Républicaine DjibouGarde Républi | 0 - 0 | GazelleGazelle |
| 05 Dec 20 | r00        | GOR MahiaGOR Mahia | 3 - 1 | APRAPR |
| 05 Dec 20 | r00        | FC PlatinumFC Platinum | 2 - 0 | Costa do SolCosta do Sol |
| 05 Dec 20 | r00        | Mekelle 70 EndertaMekelle 70 En | 0 - 0 | Al-Ahly BenghaziAl-Ahly Bengh |
| 05 Dec 20 | r00        | NkanaNkana | 0 - 0 | BantuBantu |
| 05 Dec 20 | r00        | Simba SCSimba SC | 0 - 0 | Plateau UnitedPlateau Unite |
| 05 Dec 20 | r00        | CS SfaxienCS Sfaxien | 3 - 1 | MlandegeMlandege |
| 05 Dec 20 | r00        | Mogadishu CityMogadishu Cit | 0 - 2 | AS SONIDEPAS SONIDEP |
| 05 Dec 20 | r00        | BouenguidiBouenguidi | 2 - 0 | Forest RangersForest Ranger |
| 05 Dec 20 | r00        | Atlético PetróleosAtlético Petr | 2 - 2 | AkonanguiAkonangui |
| 05 Dec 20 | r00        | Stade MalienStade Malien | 2 - 0 | Ashanti Golden BoysAshanti Golde |
| 05 Dec 20 | r00        | Kaizer ChiefsKaizer Chiefs | 0 - 0 | PWD BamendaPWD Bamenda |
| 06 Dec 20 | r00        | ZilimadjouZilimadjou | 1 - 1 | Jwaneng GalaxyJwaneng Galax |
| 06 Dec 20 | r00        | Al-Hilal OmdurmanAl-Hilal Omdu | 1 - 0 | VipersVipers |
| 06 Dec 20 | r00        | Le Messager NgoziLe Messager N | 1 - 1 | Young BuffaloesYoung Buffalo |
| 06 Dec 20 | r00        | EnyimbaEnyimba | 1 - 1 | RahimoRahimo |
| 06 Dec 20 | r00        | Asante KotokoAsante Kotoko | 2 - 0 | NouadhibouNouadhibou |
| 06 Dec 20 | r00        | ASC KaraASC Kara | 2 - 1 | RC AbidjanRC Abidjan |
| 06 Dec 20 | r00        | Al-Nasr SCSCAl-Nasr SCSC | 0 - 2 | CR BelouizdadCR Belouizdad |
| 06 Dec 20 | r00        | TeunguethTeungueth | 2 - 0 | Gambia Armed Forces FCGambia Armed |
| 19 Dec 20 | r00        | MC AlgerMC Alger | 5 - 1 | Les Buffles du BorgouLes Buffles d |
| 19 Dec 20 | r00        | MC AlgerMC Alger | 5 - 1 | Les Buffles du BorgouLes Buffles d |
| 22 Dec 20 | r00        | Young BuffaloesYoung Buffalo | 2 - 2 | Vita ClubVita Club |
| 22 Dec 20 | r00        | Jwaneng GalaxyJwaneng Galax | 0 - 2 | Mamelodi SundownsMamelodi Sund |
| 22 Dec 20 | r00        | TeunguethTeungueth | 0 - 0 | Raja CasablancaRaja Casablan |
| 23 Dec 20 | r00        | GazelleGazelle | 0 - 0 | Zamalek SCZamalek SC |
| 23 Dec 20 | r00        | Al-MerrikhAl-Merrikh | 3 - 0 | EnyimbaEnyimba |
| 23 Dec 20 | r00        | FC PlatinumFC Platinum | 1 - 0 | Simba SCSimba SC |
| 23 Dec 20 | r00        | NkanaNkana | 1 - 1 | Atlético PetróleosAtlético Petr |
| 23 Dec 20 | r00        | AS SONIDEPAS SONIDEP | 0 - 1 | Al Ahly SCAl Ahly SC |
| 23 Dec 20 | r00        | BouenguidiBouenguidi | 1 - 2 | TP MazembeTP Mazembe |
| 23 Dec 20 | r00        | Asante KotokoAsante Kotoko | 0 - 1 | Al-Hilal OmdurmanAl-Hilal Omdu |
| 23 Dec 20 | r00        | Stade MalienStade Malien | 1 - 0 | Wydad CasablancaWydad Casabla |
| 23 Dec 20 | r00        | Kaizer ChiefsKaizer Chiefs | 0 - 0 | Primeiro de AgostoPrimeiro de A |
| 23 Dec 20 | r00        | Al-Ahly BenghaziAl-Ahly Bengh | 0 - 0 | Espérance de TunisEspérance de |
| 23 Dec 20 | r00        | RC AbidjanRC Abidjan | 1 - 1 | Horoya ACHoroya AC |
| 26 Dec 20 | r00        | CR BelouizdadCR Belouizdad | 6 - 0 | GOR MahiaGOR Mahia |
| 28 Dec 20 | r00        | MC AlgerMC Alger | 2 - 0 | CS SfaxienCS Sfaxien |
| 05 Jan 21 | r00        | Zamalek SCZamalek SC | 0 - 0 | GazelleGazelle |
| 05 Jan 21 | r00        | Primeiro de AgostoPrimeiro de A | 0 - 1 | Kaizer ChiefsKaizer Chiefs |
| 05 Jan 21 | r00        | Mamelodi SundownsMamelodi Sund | 3 - 1 | Jwaneng GalaxyJwaneng Galax |
| 05 Jan 21 | r00        | Al Ahly SCAl Ahly SC | 4 - 0 | AS SONIDEPAS SONIDEP |
| 05 Jan 21 | r00        | Raja CasablancaRaja Casablan | 0 - 0 | TeunguethTeungueth |
| 06 Jan 21 | r00        | GOR MahiaGOR Mahia | 1 - 2 | CR BelouizdadCR Belouizdad |
| 06 Jan 21 | r00        | Al-Hilal OmdurmanAl-Hilal Omdu | 2 - 0 | Asante KotokoAsante Kotoko |
| 06 Jan 21 | r00        | TP MazembeTP Mazembe | 2 - 1 | BouenguidiBouenguidi |
| 06 Jan 21 | r00        | CS SfaxienCS Sfaxien | 1 - 0 | MC AlgerMC Alger |
| 06 Jan 21 | r00        | Simba SCSimba SC | 4 - 0 | FC PlatinumFC Platinum |
| 06 Jan 21 | r00        | Espérance de TunisEspérance de | 3 - 2 | Al-Ahly BenghaziAl-Ahly Bengh |
| 06 Jan 21 | r00        | EnyimbaEnyimba | 2 - 1 | Al-MerrikhAl-Merrikh |
| 06 Jan 21 | r00        | Vita ClubVita Club | 4 - 1 | Young BuffaloesYoung Buffalo |
| 06 Jan 21 | r00        | Wydad CasablancaWydad Casabla | 3 - 0 | Stade MalienStade Malien |
| 06 Jan 21 | r00        | Atlético PetróleosAtlético Petr | 1 - 0 | NkanaNkana |
| 06 Jan 21 | r00        | Horoya ACHoroya AC | 1 - 0 | RC AbidjanRC Abidjan |
| |
| 12 Feb 21 | r01        | Vita ClubVita Club | 0 - 1 | Simba SCSimba SC |
| 12 Feb 21 | r01        | Zamalek SCZamalek SC | 0 - 0 | MC AlgerMC Alger |
| 13 Feb 21 | r01        | TP MazembeTP Mazembe | 0 - 0 | CR BelouizdadCR Belouizdad |
| 13 Feb 21 | r01        | Espérance de TunisEspérance de | 2 - 1 | TeunguethTeungueth |
| 13 Feb 21 | r01        | Mamelodi SundownsMamelodi Sund | 2 - 0 | Al-Hilal OmdurmanAl-Hilal Omdu |
| 13 Feb 21 | r01        | Horoya ACHoroya AC | 2 - 0 | Atlético PetróleosAtlético Petr |
| 16 Feb 21 | r01        | Al Ahly SCAl Ahly SC | 3 - 0 | Al-MerrikhAl-Merrikh |
| |
| 23 Feb 21 | r02        | Simba SCSimba SC | 1 - 0 | Al Ahly SCAl Ahly SC |
| 23 Feb 21 | r02        | Al-MerrikhAl-Merrikh | 1 - 4 | Vita ClubVita Club |
| 23 Feb 21 | r02        | Atlético PetróleosAtlético Petr | 0 - 1 | Wydad CasablancaWydad Casabla |
| 23 Feb 21 | r02        | Kaizer ChiefsKaizer Chiefs | 0 - 0 | Horoya ACHoroya AC |
| 23 Feb 21 | r02        | TeunguethTeungueth | 0 - 0 | Zamalek SCZamalek SC |
| 23 Feb 21 | r02        | MC AlgerMC Alger | 1 - 1 | Espérance de TunisEspérance de |
| 24 Feb 21 | r02        | Al-Hilal OmdurmanAl-Hilal Omdu | 0 - 0 | TP MazembeTP Mazembe |
| 28 Feb 21 | r02        | CR BelouizdadCR Belouizdad | 1 - 5 | Mamelodi SundownsMamelodi Sund |
| |
| 28 Feb 21 | r01        | Wydad CasablancaWydad Casabla | 4 - 0 | Kaizer ChiefsKaizer Chiefs |
| |
| 05 Mar 21 | r03        | CR BelouizdadCR Belouizdad | 1 - 1 | Al-Hilal OmdurmanAl-Hilal Omdu |
| 06 Mar 21 | r03        | Al-MerrikhAl-Merrikh | 0 - 0 | Simba SCSimba SC |
| 06 Mar 21 | r03        | TP MazembeTP Mazembe | 1 - 2 | Mamelodi SundownsMamelodi Sund |
| 06 Mar 21 | r03        | Kaizer ChiefsKaizer Chiefs | 2 - 0 | Atlético PetróleosAtlético Petr |
| 06 Mar 21 | r03        | TeunguethTeungueth | 0 - 1 | MC AlgerMC Alger |
| 06 Mar 21 | r03        | Espérance de TunisEspérance de | 3 - 1 | Zamalek SCZamalek SC |
| 06 Mar 21 | r03        | Al Ahly SCAl Ahly SC | 2 - 2 | Vita ClubVita Club |