| 22 Apr 22 | r05     | SepahanSepahan | 2 - 1 | PakhtakorPakhtakor |
| 22 Apr 22 | r05 | Shabab Al-Ahli DubaiShabab Al-Ahl | 2 - 1 | Ahal FKAhal FK |
| 22 Apr 22 | r05 | Al-Quwa Al-JawiyaAl-Quwa Al-Ja | 3 - 2 | Al JaziraAl Jazira |
| 22 Apr 22 | r05 | Al-GharafaAl-Gharafa | 0 - 1 | Foolad FCFoolad FC |
| 22 Apr 22 | r05 | Al ShababAl Shabab | 6 - 0 | Mumbai CityMumbai City |
| 22 Apr 22 | r05 | Al-TaawonAl-Taawon | 3 - 4 | Al-Duhail SCAl-Duhail SC |
| 23 Apr 22 | r05 | Al-Rayyan SCAl-Rayyan SC | 1 - 0 | IstiklolIstiklol |
| 23 Apr 22 | r05 | NasafNasaf | 3 - 1 | Al-SaddAl-Sadd |
| 23 Apr 22 | r05 | Al-FaisalyAl-Faisaly | 1 - 1 | Al-WehdatAl-Wehdat |
| 23 Apr 22 | r05 | Al SharjahAl Sharjah | 2 - 2 | Al HilalAl Hilal |
| 27 Apr 22 | r05 | Ulsan Hyundai FCUlsan Hyundai | 3 - 2 | Kawasaki FrontaleKawasaki Fron |
| 27 Apr 22 | r05 | Urawa Red DiamondsUrawa Red Dia | 6 - 0 | Home UnitedHome United |
| 27 Apr 22 | r05 | Melbourne City FCMelbourne Cit | 0 - 0 | BG Pathum UnitedBG Pathum Uni |
| 27 Apr 22 | r05 | Guangzhou EvergrandeGuangzhou Eve | 0 - 2 | Johor Darul TazimJohor Darul T |
| 27 Apr 22 | r05 | Jeonnam DragonsJeonnam Drago | 2 - 0 | Ceres–NegrosCeres–Negros |
| 27 Apr 22 | r05 | Daegu FCDaegu FC | 4 - 0 | Shandong LunengShandong Lune |
| 28 Apr 22 | r05 | Yokohama F MarinosYokohama F Ma | 2 - 0 | Hoang Anh Gia LaiHoang Anh Gia |
| 28 Apr 22 | r05 | Vissel KobeVissel Kobe | - | Shanghai East Asia FCShanghai East |
| 28 Apr 22 | r05 | Chiangrai UnitedChiangrai Uni | 2 - 3 | KitcheeKitchee |
| 28 Apr 22 | r05 | Sydney FCSydney FC | 2 - 3 | Jeonbuk Hyundai MotorsJeonbuk Hyund |
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