| 08 Mar 22 | Qualifier   | Sydney FCSydney FC | 5 - 0 | Kaya FC–IloiloKaya FC–Iloil |
| 15 Mar 22 | Qualifier | Ulsan Hyundai FCUlsan Hyundai | 3 - 0 | Port FCPort FC |
| 15 Mar 22 | Qualifier   | Vissel KobeVissel Kobe | 4 - 3 | Melbourne VictoryMelbourne Vic |
| 15 Mar 22 | Qualifier | Daegu FCDaegu FC | 1 - 1 | Buriram UnitedBuriram Unite |
| 15 Mar 22 | Qualifier | Al-TaawonAl-Taawon | 1 - 1 | Al-JaishAl-Jaish |
| 15 Mar 22 | Qualifier | Bani YasBani Yas | 0 - 2 | NasafNasaf |
| 15 Mar 22 | Qualifier | Al SharjahAl Sharjah | 1 - 1 | Al-ZawraaAl-Zawraa |
| |
| 07 Apr 22 | r01 | Foolad FCFoolad FC | 0 - 0 | Al-GharafaAl-Gharafa |
| 07 Apr 22 | r01 | PakhtakorPakhtakor | 1 - 3 | SepahanSepahan |
| 07 Apr 22 | r01 | Ahal FKAhal FK | 1 - 1 | Shabab Al-Ahli DubaiShabab Al-Ahl |
| 07 Apr 22 | r01 | Al-Duhail SCAl-Duhail SC | 1 - 2 | Al-TaawonAl-Taawon |
| 08 Apr 22 | r01 | Mumbai CityMumbai City | 0 - 3 | Al ShababAl Shabab |
| 08 Apr 22 | r01 | IstiklolIstiklol | 2 - 3 | Al-Rayyan SCAl-Rayyan SC |
| 08 Apr 22 | r01 | Al-SaddAl-Sadd | 1 - 1 | NasafNasaf |
| 08 Apr 22 | r01 | Al JaziraAl Jazira | 1 - 2 | Al-Quwa Al-JawiyaAl-Quwa Al-Ja |
| 08 Apr 22 | r01 | Al-WehdatAl-Wehdat | 1 - 1 | Al-FaisalyAl-Faisaly |
| 08 Apr 22 | r01 | Al HilalAl Hilal | 2 - 1 | Al SharjahAl Sharjah |
| |
| 10 Apr 22 | r02 | SepahanSepahan | 0 - 1 | Al-Duhail SCAl-Duhail SC |
| 10 Apr 22 | r02 | Shabab Al-Ahli DubaiShabab Al-Ahl | 1 - 1 | Foolad FCFoolad FC |
| 10 Apr 22 | r02 | Al-GharafaAl-Gharafa | 2 - 0 | Ahal FKAhal FK |
| 10 Apr 22 | r02 | Al-TaawonAl-Taawon | 0 - 1 | PakhtakorPakhtakor |
| 11 Apr 22 | r02 | Al-Quwa Al-JawiyaAl-Quwa Al-Ja | 1 - 2 | Mumbai CityMumbai City |
| 11 Apr 22 | r02 | Al-Rayyan SCAl-Rayyan SC | 0 - 3 | Al HilalAl Hilal |
| 11 Apr 22 | r02 | NasafNasaf | 2 - 0 | Al-WehdatAl-Wehdat |
| 11 Apr 22 | r02 | Al ShababAl Shabab | 3 - 0 | Al JaziraAl Jazira |
| 11 Apr 22 | r02 | Al-FaisalyAl-Faisaly | 2 - 1 | Al-SaddAl-Sadd |
| 11 Apr 22 | r02 | Al SharjahAl Sharjah | 2 - 1 | IstiklolIstiklol |
| |
| 14 Apr 22 | r03 | Al-Duhail SCAl-Duhail SC | 3 - 2 | PakhtakorPakhtakor |
| 14 Apr 22 | r03 | Foolad FCFoolad FC | 1 - 0 | Ahal FKAhal FK |
| 14 Apr 22 | r03 | Al JaziraAl Jazira | 1 - 0 | Mumbai CityMumbai City |
| 14 Apr 22 | r03 | Al-GharafaAl-Gharafa | 1 - 1 | Shabab Al-Ahli DubaiShabab Al-Ahl |
| 14 Apr 22 | r03 | Al-Quwa Al-JawiyaAl-Quwa Al-Ja | 1 - 1 | Al ShababAl Shabab |
| 14 Apr 22 | r03 | Al-TaawonAl-Taawon | 3 - 0 | SepahanSepahan |
| |
| 15 Apr 22 | r01 | Kawasaki FrontaleKawasaki Fron | 1 - 1 | Ulsan Hyundai FCUlsan Hyundai |
| 15 Apr 22 | r01 | BG Pathum UnitedBG Pathum Uni | 1 - 1 | Melbourne City FCMelbourne Cit |
| 15 Apr 22 | r01 | Shandong LunengShandong Lune | 0 - 7 | Daegu FCDaegu FC |
| 15 Apr 22 | r01 | Home UnitedHome United | 1 - 4 | Urawa Red DiamondsUrawa Red Dia |
| 15 Apr 22 | r01 | Johor Darul TazimJohor Darul T | 5 - 0 | Guangzhou EvergrandeGuangzhou Eve |
| 15 Apr 22 | r01 | Ceres–NegrosCeres–Negros | 0 - 1 | Jeonnam DragonsJeonnam Drago |
| |
| 15 Apr 22 | r03 | Al-SaddAl-Sadd | 5 - 2 | Al-WehdatAl-Wehdat |
| 15 Apr 22 | r03 | Al SharjahAl Sharjah | 1 - 1 | Al-Rayyan SCAl-Rayyan SC |
| 15 Apr 22 | r03 | Al HilalAl Hilal | 1 - 0 | IstiklolIstiklol |
| 15 Apr 22 | r03 | NasafNasaf | 0 - 1 | Al-FaisalyAl-Faisaly |
| |
| 16 Apr 22 | r01 | Hoang Anh Gia LaiHoang Anh Gia | 1 - 2 | Yokohama F MarinosYokohama F Ma |
| 16 Apr 22 | r01 | KitcheeKitchee | 1 - 0 | Chiangrai UnitedChiangrai Uni |
| 16 Apr 22 | r01 | Jeonbuk Hyundai MotorsJeonbuk Hyund | 0 - 0 | Sydney FCSydney FC |
| 16 Apr 22 | r01 | Shanghai East Asia FCShanghai East | - | Vissel KobeVissel Kobe |
| |
| 18 Apr 22 | r02 | Guangzhou EvergrandeGuangzhou Eve | 0 - 8 | Kawasaki FrontaleKawasaki Fron |
| 18 Apr 22 | r02 | Jeonnam DragonsJeonnam Drago | 0 - 2 | BG Pathum UnitedBG Pathum Uni |
| 18 Apr 22 | r02 | Daegu FCDaegu FC | 0 - 3 | Home UnitedHome United |
| 18 Apr 22 | r02 | Melbourne City FCMelbourne Cit | 3 - 0 | Ceres–NegrosCeres–Negros |
| 18 Apr 22 | r02 | Urawa Red DiamondsUrawa Red Dia | 5 - 0 | Shandong LunengShandong Lune |
| 18 Apr 22 | r02 | Ulsan Hyundai FCUlsan Hyundai | 1 - 2 | Johor Darul TazimJohor Darul T |
| |
| 18 Apr 22 | r04 | PakhtakorPakhtakor | 0 - 3 | Al-Duhail SCAl-Duhail SC |
| 18 Apr 22 | r04 | Ahal FKAhal FK | 0 - 1 | Foolad FCFoolad FC |
| 18 Apr 22 | r04 | Mumbai CityMumbai City | 0 - 0 | Al JaziraAl Jazira |
| 18 Apr 22 | r04 | Shabab Al-Ahli DubaiShabab Al-Ahl | 8 - 2 | Al-GharafaAl-Gharafa |
| 18 Apr 22 | r04 | Al ShababAl Shabab | 3 - 0 | Al-Quwa Al-JawiyaAl-Quwa Al-Ja |
| 18 Apr 22 | r04 | SepahanSepahan | 1 - 1 | Al-TaawonAl-Taawon |
| |
| 19 Apr 22 | r02 | Sydney FCSydney FC | 1 - 1 | Hoang Anh Gia LaiHoang Anh Gia |
| 19 Apr 22 | r02 | Vissel KobeVissel Kobe | 2 - 1 | KitcheeKitchee |
| 19 Apr 22 | r02 | Chiangrai UnitedChiangrai Uni | - | Shanghai East Asia FCShanghai East |
| 19 Apr 22 | r02 | Yokohama F MarinosYokohama F Ma | 0 - 1 | Jeonbuk Hyundai MotorsJeonbuk Hyund |
| |
| 19 Apr 22 | r04 | Al-WehdatAl-Wehdat | 3 - 1 | Al-SaddAl-Sadd |
| 19 Apr 22 | r04 | Al-Rayyan SCAl-Rayyan SC | 3 - 1 | Al SharjahAl Sharjah |
| 19 Apr 22 | r04 | IstiklolIstiklol | 0 - 3 | Al HilalAl Hilal |
| 19 Apr 22 | r04 | Al-FaisalyAl-Faisaly | 0 - 0 | NasafNasaf |
| |
| 21 Apr 22 | r03 | Ulsan Hyundai FCUlsan Hyundai | 3 - 0 | Guangzhou EvergrandeGuangzhou Eve |
| 21 Apr 22 | r03 | BG Pathum UnitedBG Pathum Uni | 5 - 0 | Ceres–NegrosCeres–Negros |
| 21 Apr 22 | r03 | Shandong LunengShandong Lune | 0 - 0 | Home UnitedHome United |
| 21 Apr 22 | r03 | Kawasaki FrontaleKawasaki Fron | 0 - 0 | Johor Darul TazimJohor Darul T |
| 21 Apr 22 | r03 | Melbourne City FCMelbourne Cit | 2 - 1 | Jeonnam DragonsJeonnam Drago |
| 21 Apr 22 | r03 | Daegu FCDaegu FC | 1 - 0 | Urawa Red DiamondsUrawa Red Dia |
| 22 Apr 22 | r03 | Jeonbuk Hyundai MotorsJeonbuk Hyund | 1 - 0 | Hoang Anh Gia LaiHoang Anh Gia |
| 22 Apr 22 | r03 | Shanghai East Asia FCShanghai East | - | KitcheeKitchee |
| 22 Apr 22 | r03 | Sydney FCSydney FC | 0 - 1 | Yokohama F MarinosYokohama F Ma |
| 22 Apr 22 | r03 | Vissel KobeVissel Kobe | 6 - 0 | Chiangrai UnitedChiangrai Uni |
| |
| 22 Apr 22 | r05 | SepahanSepahan | 2 - 1 | PakhtakorPakhtakor |
| 22 Apr 22 | r05 | Shabab Al-Ahli DubaiShabab Al-Ahl | 2 - 1 | Ahal FKAhal FK |
| 22 Apr 22 | r05 | Al-Quwa Al-JawiyaAl-Quwa Al-Ja | 3 - 2 | Al JaziraAl Jazira |
| 22 Apr 22 | r05 | Al-GharafaAl-Gharafa | 0 - 1 | Foolad FCFoolad FC |
| 22 Apr 22 | r05 | Al ShababAl Shabab | 6 - 0 | Mumbai CityMumbai City |
| 22 Apr 22 | r05 | Al-TaawonAl-Taawon | 3 - 4 | Al-Duhail SCAl-Duhail SC |
| 23 Apr 22 | r05 | Al-Rayyan SCAl-Rayyan SC | 1 - 0 | IstiklolIstiklol |
| 23 Apr 22 | r05 | NasafNasaf | 3 - 1 | Al-SaddAl-Sadd |
| 23 Apr 22 | r05 | Al-FaisalyAl-Faisaly | 1 - 1 | Al-WehdatAl-Wehdat |
| 23 Apr 22 | r05 | Al SharjahAl Sharjah | 2 - 2 | Al HilalAl Hilal |
| |
| 24 Apr 22 | r04 | Guangzhou EvergrandeGuangzhou Eve | 0 - 5 | Ulsan Hyundai FCUlsan Hyundai |
| 24 Apr 22 | r04 | Jeonnam DragonsJeonnam Drago | 1 - 1 | Melbourne City FCMelbourne Cit |
| 24 Apr 22 | r04 | Urawa Red DiamondsUrawa Red Dia | 0 - 0 | Daegu FCDaegu FC |
| 24 Apr 22 | r04 | Johor Darul TazimJohor Darul T | 0 - 5 | Kawasaki FrontaleKawasaki Fron |
| 24 Apr 22 | r04 | Ceres–NegrosCeres–Negros | 1 - 3 | BG Pathum UnitedBG Pathum Uni |
| 24 Apr 22 | r04 | Home UnitedHome United | 3 - 2 | Shandong LunengShandong Lune |
| 25 Apr 22 | r04 | KitcheeKitchee | - | Shanghai East Asia FCShanghai East |
| 25 Apr 22 | r04 | Yokohama F MarinosYokohama F Ma | 3 - 0 | Sydney FCSydney FC |
| 25 Apr 22 | r04 | Hoang Anh Gia LaiHoang Anh Gia | 1 - 1 | Jeonbuk Hyundai MotorsJeonbuk Hyund |
| 25 Apr 22 | r04 | Chiangrai UnitedChiangrai Uni | 0 - 0 | Vissel KobeVissel Kobe |
| |
| 26 Apr 22 | r06 | Al-Duhail SCAl-Duhail SC | 5 - 2 | SepahanSepahan |
| 26 Apr 22 | r06 | Ahal FKAhal FK | 4 - 2 | Al-GharafaAl-Gharafa |
| 26 Apr 22 | r06 | Foolad FCFoolad FC | 1 - 1 | Shabab Al-Ahli DubaiShabab Al-Ahl |
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