| 10 Apr 22 | r02     | SepahanSepahan | 0 - 1 | Al-Duhail SCAl-Duhail SC |
| 10 Apr 22 | r02 | Shabab Al-Ahli DubaiShabab Al-Ahl | 1 - 1 | Foolad FCFoolad FC |
| 10 Apr 22 | r02 | Al-GharafaAl-Gharafa | 2 - 0 | Ahal FKAhal FK |
| 10 Apr 22 | r02 | Al-TaawonAl-Taawon | 0 - 1 | PakhtakorPakhtakor |
| 11 Apr 22 | r02 | Al-Quwa Al-JawiyaAl-Quwa Al-Ja | 1 - 2 | Mumbai CityMumbai City |
| 11 Apr 22 | r02 | Al-Rayyan SCAl-Rayyan SC | 0 - 3 | Al HilalAl Hilal |
| 11 Apr 22 | r02 | NasafNasaf | 2 - 0 | Al-WehdatAl-Wehdat |
| 11 Apr 22 | r02 | Al ShababAl Shabab | 3 - 0 | Al JaziraAl Jazira |
| 11 Apr 22 | r02 | Al-FaisalyAl-Faisaly | 2 - 1 | Al-SaddAl-Sadd |
| 11 Apr 22 | r02 | Al SharjahAl Sharjah | 2 - 1 | IstiklolIstiklol |
| 18 Apr 22 | r02 | Guangzhou EvergrandeGuangzhou Eve | 0 - 8 | Kawasaki FrontaleKawasaki Fron |
| 18 Apr 22 | r02 | Jeonnam DragonsJeonnam Drago | 0 - 2 | BG Pathum UnitedBG Pathum Uni |
| 18 Apr 22 | r02 | Daegu FCDaegu FC | 0 - 3 | Home UnitedHome United |
| 18 Apr 22 | r02 | Melbourne City FCMelbourne Cit | 3 - 0 | Ceres–NegrosCeres–Negros |
| 18 Apr 22 | r02 | Urawa Red DiamondsUrawa Red Dia | 5 - 0 | Shandong LunengShandong Lune |
| 18 Apr 22 | r02 | Ulsan Hyundai FCUlsan Hyundai | 1 - 2 | Johor Darul TazimJohor Darul T |
| 19 Apr 22 | r02 | Sydney FCSydney FC | 1 - 1 | Hoang Anh Gia LaiHoang Anh Gia |
| 19 Apr 22 | r02 | Vissel KobeVissel Kobe | 2 - 1 | KitcheeKitchee |
| 19 Apr 22 | r02 | Chiangrai UnitedChiangrai Uni | - | Shanghai East Asia FCShanghai East |
| 19 Apr 22 | r02 | Yokohama F MarinosYokohama F Ma | 0 - 1 | Jeonbuk Hyundai MotorsJeonbuk Hyund |
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