| 31 Jul 21 | r02   | Yverdon SportYverdon Sport | 1 - 3 | Stade Lausanne OuchyStade Lausann |
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| 03 Aug 21 | r01 | ThunThun | 3 - 0 | Yverdon SportYverdon Sport |
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| 07 Aug 21 | r03 | FC WilFC Wil | 3 - 0 | Yverdon SportYverdon Sport |
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| 21 Aug 21 | r04 | Yverdon SportYverdon Sport | 1 - 1 | Neuchâtel XamaxNeuchâtel Xam |
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| 29 Aug 21 | r05 | SchaffhausenSchaffhausen | 4 - 3 | Yverdon SportYverdon Sport |
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| 10 Sep 21 | r06  | Yverdon SportYverdon Sport | 1 - 1 | FC AarauFC Aarau |
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| 22 Sep 21 | r07 | SC KriensSC Kriens | 0 - 2 | Yverdon SportYverdon Sport |
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| 25 Sep 21 | r08 | Yverdon SportYverdon Sport | 2 - 0 | VaduzVaduz |
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| 02 Oct 21 | r09 | FC WinterthurFC Winterthur | 1 - 0 | Yverdon SportYverdon Sport |
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| 16 Oct 21 | r10 | Yverdon SportYverdon Sport | 3 - 0 | FC WilFC Wil |
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| 30 Oct 21 | r12 | Yverdon SportYverdon Sport | 1 - 0 | ThunThun |
| 30 Oct 21 | r12 | Yverdon SportYverdon Sport | 1 - 0 | ThunThun |
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| 02 Nov 21 | r11 | Stade Lausanne OuchyStade Lausann | 0 - 0 | Yverdon SportYverdon Sport |
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| 06 Nov 21 | r13 | FC AarauFC Aarau | 1 - 0 | Yverdon SportYverdon Sport |
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| 19 Nov 21 | r14 | Yverdon SportYverdon Sport | 2 - 1 | FC WinterthurFC Winterthur |
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| 26 Nov 21 | r15 | Neuchâtel XamaxNeuchâtel Xam | 2 - 1 | Yverdon SportYverdon Sport |
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| 03 Dec 21 | r16 | Yverdon SportYverdon Sport | 2 - 1 | SchaffhausenSchaffhausen |
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| 10 Dec 21 | r17 | VaduzVaduz | 2 - 2 | Yverdon SportYverdon Sport |
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| 17 Dec 21 | r18 | Yverdon SportYverdon Sport | 2 - 0 | SC KriensSC Kriens |
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| 28 Jan 22 | r19 | Yverdon SportYverdon Sport | 0 - 0 | Stade Lausanne OuchyStade Lausann |
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| 05 Feb 22 | r20 | SC KriensSC Kriens | 0 - 3 | Yverdon SportYverdon Sport |
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| 12 Feb 22 | r21 | Yverdon SportYverdon Sport | 0 - 0 | Neuchâtel XamaxNeuchâtel Xam |
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| 19 Feb 22 | r22 | VaduzVaduz | 2 - 0 | Yverdon SportYverdon Sport |
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| 25 Feb 22 | r23 | Yverdon SportYverdon Sport | 2 - 2 | ThunThun |
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| 28 Feb 22 | r24 | FC WinterthurFC Winterthur | 2 - 0 | Yverdon SportYverdon Sport |
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| 04 Mar 22 | r25 | Yverdon SportYverdon Sport | 2 - 2 | FC WilFC Wil |
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| 11 Mar 22 | r26 | SchaffhausenSchaffhausen | 3 - 1 | Yverdon SportYverdon Sport |
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| 19 Mar 22 | r27 | FC AarauFC Aarau | 0 - 2 | Yverdon SportYverdon Sport |
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| 01 Apr 22 | r28 | Yverdon SportYverdon Sport | 1 - 4 | VaduzVaduz |
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| 09 Apr 22 | r29 | Stade Lausanne OuchyStade Lausann | 0 - 1 | Yverdon SportYverdon Sport |
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| 18 Apr 22 | r30 | Yverdon SportYverdon Sport | 0 - 1 | SchaffhausenSchaffhausen |
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| 24 Apr 22 | r31 | Yverdon SportYverdon Sport | 2 - 2 | FC WinterthurFC Winterthur |
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| 30 Apr 22 | r32 | FC WilFC Wil | 2 - 2 | Yverdon SportYverdon Sport |
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| 06 May 22 | r33 | Yverdon SportYverdon Sport | 0 - 4 | FC AarauFC Aarau |
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| 10 May 22 | r34 | Neuchâtel XamaxNeuchâtel Xam | 1 - 1 | Yverdon SportYverdon Sport |
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| 14 May 22 | r35 | Yverdon SportYverdon Sport | 3 - 2 | SC KriensSC Kriens |
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| 21 May 22 | r36 | ThunThun | 2 - 1 | Yverdon SportYverdon Sport |
Team 2021-2022 Schedules
Aarau
Bellinzona
Étoile Carouge
Neuchâtel Xamax
Rapperswil-Jona
Stade Lausanne Ouchy
Stade Nyonnais
Vaduz
Wil
Yverdon Sport
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