| 28 Jul 21 | r01   | SchaffhausenSchaffhausen | 1 - 1 | SC KriensSC Kriens |
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| 31 Jul 21 | r02 | SC KriensSC Kriens | 1 - 3 | ThunThun |
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| 06 Aug 21 | r03 | Neuchâtel XamaxNeuchâtel Xam | 4 - 0 | SC KriensSC Kriens |
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| 28 Aug 21 | r05 | SC KriensSC Kriens | 2 - 3 | FC WinterthurFC Winterthur |
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| 03 Sep 21 | r04 | SC KriensSC Kriens | 0 - 2 | FC WilFC Wil |
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| 12 Sep 21 | r06 | VaduzVaduz | 4 - 1 | SC KriensSC Kriens |
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| 22 Sep 21 | r07 | SC KriensSC Kriens | 0 - 2 | Yverdon SportYverdon Sport |
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| 25 Sep 21 | r08 | Stade Lausanne OuchyStade Lausann | 5 - 0 | SC KriensSC Kriens |
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| 03 Oct 21 | r09 | FC AarauFC Aarau | 0 - 0 | SC KriensSC Kriens |
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| 16 Oct 21 | r10 | SC KriensSC Kriens | 0 - 0 | SchaffhausenSchaffhausen |
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| 23 Oct 21 | r11 | FC WinterthurFC Winterthur | 6 - 1 | SC KriensSC Kriens |
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| 30 Oct 21 | r12 | SC KriensSC Kriens | 1 - 0 | Stade Lausanne OuchyStade Lausann |
| 30 Oct 21 | r12 | SC KriensSC Kriens | 1 - 0 | Stade Lausanne OuchyStade Lausann |
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| 06 Nov 21 | r13 | FC WilFC Wil | 4 - 0 | SC KriensSC Kriens |
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| 20 Nov 21 | r14 | SC KriensSC Kriens | 0 - 1 | Neuchâtel XamaxNeuchâtel Xam |
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| 26 Nov 21 | r15 | ThunThun | 3 - 1 | SC KriensSC Kriens |
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| 04 Dec 21 | r16 | SC KriensSC Kriens | 1 - 3 | VaduzVaduz |
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| 14 Dec 21 | r17 | SC KriensSC Kriens | 1 - 2 | FC AarauFC Aarau |
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| 17 Dec 21 | r18 | Yverdon SportYverdon Sport | 2 - 0 | SC KriensSC Kriens |
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| 30 Jan 22 | r19  | FC WinterthurFC Winterthur | 3 - 0 | SC KriensSC Kriens |
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| 05 Feb 22 | r20 | SC KriensSC Kriens | 0 - 3 | Yverdon SportYverdon Sport |
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| 11 Feb 22 | r21 | Stade Lausanne OuchyStade Lausann | 2 - 1 | SC KriensSC Kriens |
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| 19 Feb 22 | r22 | SC KriensSC Kriens | 0 - 5 | FC AarauFC Aarau |
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| 25 Feb 22 | r23 | Neuchâtel XamaxNeuchâtel Xam | 2 - 1 | SC KriensSC Kriens |
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| 01 Mar 22 | r24 | FC WilFC Wil | 3 - 1 | SC KriensSC Kriens |
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| 05 Mar 22 | r25 | SC KriensSC Kriens | 0 - 1 | ThunThun |
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| 12 Mar 22 | r26 | VaduzVaduz | 3 - 2 | SC KriensSC Kriens |
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| 19 Mar 22 | r27 | SC KriensSC Kriens | 0 - 0 | SchaffhausenSchaffhausen |
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| 02 Apr 22 | r28 | ThunThun | 3 - 1 | SC KriensSC Kriens |
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| 09 Apr 22 | r29 | SC KriensSC Kriens | 2 - 1 | FC WilFC Wil |
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| 16 Apr 22 | r30 | SC KriensSC Kriens | 0 - 5 | Neuchâtel XamaxNeuchâtel Xam |
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| 23 Apr 22 | r31 | FC AarauFC Aarau | 3 - 2 | SC KriensSC Kriens |
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| 30 Apr 22 | r32 | SC KriensSC Kriens | 2 - 1 | Stade Lausanne OuchyStade Lausann |
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| 06 May 22 | r33 | SchaffhausenSchaffhausen | 4 - 1 | SC KriensSC Kriens |
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| 10 May 22 | r34 | SC KriensSC Kriens | 0 - 1 | VaduzVaduz |
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| 14 May 22 | r35 | Yverdon SportYverdon Sport | 3 - 2 | SC KriensSC Kriens |
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| 21 May 22 | r36 | SC KriensSC Kriens | 0 - 5 | FC WinterthurFC Winterthur |
Team 2021-2022 Schedules
Aarau
Étoile Carouge
Kriens
Neuchâtel Xamax
Rapperswil-Jona
Stade Lausanne Ouchy
Stade Nyonnais
Wil
Winterthur
Yverdon Sport
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