| 01 Aug 21 | r02   | VaduzVaduz | 1 - 2 | Neuchâtel XamaxNeuchâtel Xam |
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| 06 Aug 21 | r03 | Neuchâtel XamaxNeuchâtel Xam | 4 - 0 | SC KriensSC Kriens |
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| 10 Aug 21 | r01 | Neuchâtel XamaxNeuchâtel Xam | 4 - 2 | FC AarauFC Aarau |
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| 21 Aug 21 | r04 | Yverdon SportYverdon Sport | 1 - 1 | Neuchâtel XamaxNeuchâtel Xam |
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| 29 Aug 21 | r05 | Neuchâtel XamaxNeuchâtel Xam | 3 - 0 | FC WilFC Wil |
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| 11 Sep 21 | r06 | FC WinterthurFC Winterthur | 2 - 1 | Neuchâtel XamaxNeuchâtel Xam |
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| 22 Sep 21 | r07 | Neuchâtel XamaxNeuchâtel Xam | 3 - 1 | Stade Lausanne OuchyStade Lausann |
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| 25 Sep 21 | r08 | ThunThun | 3 - 2 | Neuchâtel XamaxNeuchâtel Xam |
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| 01 Oct 21 | r09 | SchaffhausenSchaffhausen | 4 - 0 | Neuchâtel XamaxNeuchâtel Xam |
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| 15 Oct 21 | r10 | Neuchâtel XamaxNeuchâtel Xam | 0 - 2 | VaduzVaduz |
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| 22 Oct 21 | r11 | FC WilFC Wil | 2 - 1 | Neuchâtel XamaxNeuchâtel Xam |
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| 29 Oct 21 | r12 | Neuchâtel XamaxNeuchâtel Xam | 1 - 1 | FC WinterthurFC Winterthur |
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| 05 Nov 21 | r13 | Neuchâtel XamaxNeuchâtel Xam | 0 - 3 | SchaffhausenSchaffhausen |
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| 20 Nov 21 | r14 | SC KriensSC Kriens | 0 - 1 | Neuchâtel XamaxNeuchâtel Xam |
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| 26 Nov 21 | r15 | Neuchâtel XamaxNeuchâtel Xam | 2 - 1 | Yverdon SportYverdon Sport |
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| 03 Dec 21 | r16 | Stade Lausanne OuchyStade Lausann | 0 - 0 | Neuchâtel XamaxNeuchâtel Xam |
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| 10 Dec 21 | r17  | Neuchâtel XamaxNeuchâtel Xam | 1 - 4 | ThunThun |
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| 17 Dec 21 | r18 | FC AarauFC Aarau | 1 - 0 | Neuchâtel XamaxNeuchâtel Xam |
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| 28 Jan 22 | r19 | FC AarauFC Aarau | 1 - 1 | Neuchâtel XamaxNeuchâtel Xam |
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| 04 Feb 22 | r20 | Neuchâtel XamaxNeuchâtel Xam | 2 - 1 | SchaffhausenSchaffhausen |
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| 12 Feb 22 | r21 | Yverdon SportYverdon Sport | 0 - 0 | Neuchâtel XamaxNeuchâtel Xam |
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| 18 Feb 22 | r22 | Neuchâtel XamaxNeuchâtel Xam | 1 - 1 | Stade Lausanne OuchyStade Lausann |
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| 25 Feb 22 | r23 | Neuchâtel XamaxNeuchâtel Xam | 2 - 1 | SC KriensSC Kriens |
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| 01 Mar 22 | r24 | ThunThun | 1 - 2 | Neuchâtel XamaxNeuchâtel Xam |
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| 04 Mar 22 | r25 | Neuchâtel XamaxNeuchâtel Xam | 2 - 4 | VaduzVaduz |
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| 12 Mar 22 | r26 | FC WilFC Wil | 2 - 0 | Neuchâtel XamaxNeuchâtel Xam |
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| 18 Mar 22 | r27 | Neuchâtel XamaxNeuchâtel Xam | 0 - 0 | FC WinterthurFC Winterthur |
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| 01 Apr 22 | r28 | SchaffhausenSchaffhausen | 2 - 1 | Neuchâtel XamaxNeuchâtel Xam |
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| 08 Apr 22 | r29 | Neuchâtel XamaxNeuchâtel Xam | 4 - 1 | ThunThun |
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| 16 Apr 22 | r30 | SC KriensSC Kriens | 0 - 5 | Neuchâtel XamaxNeuchâtel Xam |
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| 22 Apr 22 | r31 | VaduzVaduz | 2 - 0 | Neuchâtel XamaxNeuchâtel Xam |
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| 29 Apr 22 | r32 | Neuchâtel XamaxNeuchâtel Xam | 0 - 3 | FC AarauFC Aarau |
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| 06 May 22 | r33 | Stade Lausanne OuchyStade Lausann | 1 - 3 | Neuchâtel XamaxNeuchâtel Xam |
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| 10 May 22 | r34 | Neuchâtel XamaxNeuchâtel Xam | 1 - 1 | Yverdon SportYverdon Sport |
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| 14 May 22 | r35 | FC WinterthurFC Winterthur | 3 - 1 | Neuchâtel XamaxNeuchâtel Xam |
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| 21 May 22 | r36 | Neuchâtel XamaxNeuchâtel Xam | 5 - 2 | FC WilFC Wil |
Team 2021-2022 Schedules
Aarau
Étoile Carouge
Kriens
Neuchâtel Xamax
Rapperswil-Jona
Stade Lausanne Ouchy
Stade Nyonnais
Wil
Winterthur
Yverdon Sport
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