| 25 Jul 21 | r01   | FC WilFC Wil | 2 - 3 | VaduzVaduz |
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| 01 Aug 21 | r02 | VaduzVaduz | 1 - 2 | Neuchâtel XamaxNeuchâtel Xam |
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| 08 Aug 21 | r03 | Stade Lausanne OuchyStade Lausann | 1 - 0 | VaduzVaduz |
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| 22 Aug 21 | r04 | SchaffhausenSchaffhausen | 1 - 1 | VaduzVaduz |
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| 27 Aug 21 | r05  | FC AarauFC Aarau | 1 - 3 | VaduzVaduz |
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| 12 Sep 21 | r06 | VaduzVaduz | 4 - 1 | SC KriensSC Kriens |
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| 21 Sep 21 | r07 | VaduzVaduz | 2 - 0 | FC WinterthurFC Winterthur |
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| 25 Sep 21 | r08 | Yverdon SportYverdon Sport | 2 - 0 | VaduzVaduz |
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| 01 Oct 21 | r09 | VaduzVaduz | 1 - 3 | ThunThun |
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| 15 Oct 21 | r10 | Neuchâtel XamaxNeuchâtel Xam | 0 - 2 | VaduzVaduz |
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| 23 Oct 21 | r11 | VaduzVaduz | 2 - 1 | SchaffhausenSchaffhausen |
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| 29 Oct 21 | r12 | VaduzVaduz | 2 - 1 | FC AarauFC Aarau |
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| 05 Nov 21 | r13 | ThunThun | 1 - 1 | VaduzVaduz |
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| 20 Nov 21 | r14 | VaduzVaduz | 1 - 2 | FC WilFC Wil |
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| 27 Nov 21 | r15 | VaduzVaduz | 2 - 1 | Stade Lausanne OuchyStade Lausann |
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| 04 Dec 21 | r16 | SC KriensSC Kriens | 1 - 3 | VaduzVaduz |
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| 10 Dec 21 | r17 | VaduzVaduz | 2 - 2 | Yverdon SportYverdon Sport |
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| 19 Dec 21 | r18 | FC WinterthurFC Winterthur | 2 - 3 | VaduzVaduz |
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| 30 Jan 22 | r19 | FC WilFC Wil | 4 - 4 | VaduzVaduz |
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| 04 Feb 22 | r20 | VaduzVaduz | 0 - 0 | FC WinterthurFC Winterthur |
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| 11 Feb 22 | r21 | SchaffhausenSchaffhausen | 4 - 2 | VaduzVaduz |
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| 19 Feb 22 | r22 | VaduzVaduz | 2 - 0 | Yverdon SportYverdon Sport |
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| 25 Feb 22 | r23 | Stade Lausanne OuchyStade Lausann | 2 - 0 | VaduzVaduz |
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| 28 Feb 22 | r24 | VaduzVaduz | 0 - 2 | FC AarauFC Aarau |
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| 04 Mar 22 | r25 | Neuchâtel XamaxNeuchâtel Xam | 2 - 4 | VaduzVaduz |
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| 12 Mar 22 | r26 | VaduzVaduz | 3 - 2 | SC KriensSC Kriens |
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| 18 Mar 22 | r27 | VaduzVaduz | 0 - 2 | ThunThun |
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| 01 Apr 22 | r28 | Yverdon SportYverdon Sport | 1 - 4 | VaduzVaduz |
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| 10 Apr 22 | r29 | VaduzVaduz | 2 - 3 | SchaffhausenSchaffhausen |
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| 16 Apr 22 | r30 | FC WinterthurFC Winterthur | 4 - 2 | VaduzVaduz |
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| 22 Apr 22 | r31 | VaduzVaduz | 2 - 0 | Neuchâtel XamaxNeuchâtel Xam |
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| 30 Apr 22 | r32 | ThunThun | 3 - 0 | VaduzVaduz |
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| 06 May 22 | r33 | VaduzVaduz | 5 - 2 | FC WilFC Wil |
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| 10 May 22 | r34 | SC KriensSC Kriens | 0 - 1 | VaduzVaduz |
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| 14 May 22 | r35 | VaduzVaduz | 2 - 2 | Stade Lausanne OuchyStade Lausann |
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| 21 May 22 | r36 | FC AarauFC Aarau | 1 - 2 | VaduzVaduz |
Team 2021-2022 Schedules
Aarau
Bellinzona
Étoile Carouge
Neuchâtel Xamax
Rapperswil-Jona
Stade Lausanne Ouchy
Stade Nyonnais
Vaduz
Wil
Yverdon Sport
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