| 13 Mar 22 | r02        | San AntonioSan Antonio | 1 - 0 | Detroit City FCDetroit City |
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| 19 Mar 22 | r03        | Detroit City FCDetroit City | 1 - 0 | Charleston BatteryCharleston Ba |
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| 26 Mar 22 | r05        | Detroit City FCDetroit City | 1 - 1 | Pittsburgh RiverhoundsPittsburgh Ri |
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| 02 Apr 22 | r06        | Detroit City FCDetroit City | 1 - 1 | Memphis 901Memphis 901 |
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| 10 Apr 22 | r08        | Atlanta United IIAtlanta Unite | 0 - 4 | Detroit City FCDetroit City |
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| 16 Apr 22 | r09        | Detroit City FCDetroit City | 1 - 0 | Birmingham LegionBirmingham Le |
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| 23 Apr 22 | r10        | Hartford AthleticHartford Athl | 1 - 2 | Detroit City FCDetroit City |
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| 30 Apr 22 | r11        | Detroit City FCDetroit City | 2 - 0 | New York RB IINew York RB I |
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| 08 May 22 | r13        | Tulsa RoughnecksTulsa Roughne | 3 - 1 | Detroit City FCDetroit City |
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| 15 May 22 | r14        | Detroit City FCDetroit City | 4 - 2 | Loudoun UnitedLoudoun Unite |
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| 19 May 22 | r15        | Miami FCMiami FC | 1 - 1 | Detroit City FCDetroit City |
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| 22 May 22 | r16        | Detroit City FCDetroit City | 3 - 1 | Atlanta United IIAtlanta Unite |
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| 05 Jun 22 | r18        | Pittsburgh RiverhoundsPittsburgh Ri | 1 - 1 | Detroit City FCDetroit City |
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| 12 Jun 22 | r20        | Detroit City FCDetroit City | 0 - 2 | Sacramento RepublicSacramento Re |
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| 18 Jun 22 | r21        | Detroit City FCDetroit City | 1 - 1 | El Paso LocomotiveEl Paso Locom |
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| 26 Jun 22 | r23        | Memphis 901Memphis 901 | 2 - 0 | Detroit City FCDetroit City |
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| 03 Jul 22 | r25        | Las Vegas LightsLas Vegas Lig | 0 - 1 | Detroit City FCDetroit City |
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| 07 Jul 22 | r26        | Detroit City FCDetroit City | 1 - 1 | Hartford AthleticHartford Athl |
| 10 Jul 22 | r26        | Indy ElevenIndy Eleven | 0 - 1 | Detroit City FCDetroit City |
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| 17 Jul 22 | r28        | Monterey Bay FCMonterey Bay | 0 - 0 | Detroit City FCDetroit City |
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| 24 Jul 22 | r29        | Detroit City FCDetroit City | 2 - 2 | New Mexico UnitedNew Mexico Un |
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| 07 Aug 22 | r32        | Tampa Bay RowdiesTampa Bay Row | 1 - 0 | Detroit City FCDetroit City |
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| 14 Aug 22 | r34        | Detroit City FCDetroit City | 1 - 1 | Oakland RootsOakland Roots |
| 18 Aug 22 | r34        | Birmingham LegionBirmingham Le | 1 - 2 | Detroit City FCDetroit City |
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| 21 Aug 22 | r35        | Detroit City FCDetroit City | 0 - 1 | Louisville CityLouisville Ci |
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| 28 Aug 22 | r36        | Charleston BatteryCharleston Ba | 0 - 3 | Detroit City FCDetroit City |
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| 04 Sep 22 | r38        | Detroit City FCDetroit City | 0 - 0 | Indy ElevenIndy Eleven |
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| 11 Sep 22 | r40        | Colorado SpringsColorado Spri | 1 - 2 | Detroit City FCDetroit City |
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| 18 Sep 22 | r41        | Detroit City FCDetroit City | 1 - 0 | Tampa Bay RowdiesTampa Bay Row |
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| 22 Sep 22 | r42        | New York RB IINew York RB I | 0 - 0 | Detroit City FCDetroit City |
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| 25 Sep 22 | r43        | Detroit City FCDetroit City | 2 - 2 | Tulsa RoughnecksTulsa Roughne |
| 01 Oct 22 | r43        | Loudoun UnitedLoudoun Unite | 0 - 4 | Detroit City FCDetroit City |
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| 06 Oct 22 | r45        | Louisville CityLouisville Ci | 2 - 1 | Detroit City FCDetroit City |
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| 15 Oct 22 | r46        | Detroit City FCDetroit City | 0 - 1 | Miami FCMiami FC |
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| 23 Oct 22 | r00        | Memphis 901Memphis 901 | 3 - 1 | Detroit City FCDetroit City |