| 02 May 21 | r01        | Birmingham LegionBirmingham Le | 0 - 1 | Indy ElevenIndy Eleven |
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| 10 May 21 | r03        | Louisville CityLouisville Ci | 1 - 1 | Birmingham LegionBirmingham Le |
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| 15 May 21 | r04        | Birmingham LegionBirmingham Le | 1 - 0 | Memphis 901Memphis 901 |
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| 23 May 21 | r05        | San AntonioSan Antonio | 2 - 1 | Birmingham LegionBirmingham Le |
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| 27 May 21 | r06        | Birmingham LegionBirmingham Le | 1 - 0 | OKC EnergyOKC Energy |
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| 30 May 21 | r07        | Atlanta United IIAtlanta Unite | 0 - 1 | Birmingham LegionBirmingham Le |
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| 06 Jun 21 | r09        | Birmingham LegionBirmingham Le | 2 - 1 | Tulsa RoughnecksTulsa Roughne |
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| 13 Jun 21 | r10        | OKC EnergyOKC Energy | 1 - 2 | Birmingham LegionBirmingham Le |
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| 17 Jun 21 | r11        | Louisville CityLouisville Ci | 2 - 0 | Birmingham LegionBirmingham Le |
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| 24 Jun 21 | r13        | Miami FCMiami FC | 0 - 1 | Birmingham LegionBirmingham Le |
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| 04 Jul 21 | r16        | Indy ElevenIndy Eleven | 0 - 1 | Birmingham LegionBirmingham Le |
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| 11 Jul 21 | r18        | Birmingham LegionBirmingham Le | 0 - 1 | Memphis 901Memphis 901 |
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| 25 Jul 21 | r22        | Indy ElevenIndy Eleven | 1 - 2 | Birmingham LegionBirmingham Le |
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| 01 Aug 21 | r23        | Birmingham LegionBirmingham Le | 2 - 2 | Atlanta United IIAtlanta Unite |
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| 05 Aug 21 | r15        | Birmingham LegionBirmingham Le | 3 - 1 | Atlanta United IIAtlanta Unite |
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| 08 Aug 21 | r26        | Tulsa RoughnecksTulsa Roughne | 3 - 1 | Birmingham LegionBirmingham Le |
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| 12 Aug 21 | r27        | Birmingham LegionBirmingham Le | 4 - 2 | Swope Park RangersSwope Park Ra |
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| 15 Aug 21 | r28        | Memphis 901Memphis 901 | 1 - 1 | Birmingham LegionBirmingham Le |
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| 22 Aug 21 | r30        | Birmingham LegionBirmingham Le | 1 - 2 | Tulsa RoughnecksTulsa Roughne |
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| 29 Aug 21 | r31        | Birmingham LegionBirmingham Le | 2 - 1 | Louisville CityLouisville Ci |
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| 02 Sep 21 | r21        | Swope Park RangersSwope Park Ra | 0 - 1 | Birmingham LegionBirmingham Le |
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| 05 Sep 21 | r33        | Memphis 901Memphis 901 | 3 - 2 | Birmingham LegionBirmingham Le |
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| 12 Sep 21 | r35        | Tulsa RoughnecksTulsa Roughne | 1 - 1 | Birmingham LegionBirmingham Le |
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| 19 Sep 21 | r37        | Birmingham LegionBirmingham Le | 1 - 1 | OKC EnergyOKC Energy |
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| 23 Sep 21 | r39        | Atlanta United IIAtlanta Unite | 0 - 4 | Birmingham LegionBirmingham Le |
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| 26 Sep 21 | r40        | Birmingham LegionBirmingham Le | 2 - 1 | Charlotte IndependenceCharlotte Ind |
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| 02 Oct 21 | r41        | Swope Park RangersSwope Park Ra | 0 - 1 | Birmingham LegionBirmingham Le |
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| 10 Oct 21 | r44        | Birmingham LegionBirmingham Le | 3 - 1 | Indy ElevenIndy Eleven |
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| 14 Oct 21 | r12        | Birmingham LegionBirmingham Le | 3 - 1 | Austin BoldAustin Bold |
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| 17 Oct 21 | r46        | OKC EnergyOKC Energy | 0 - 0 | Birmingham LegionBirmingham Le |
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| 24 Oct 21 | r48        | Birmingham LegionBirmingham Le | 6 - 0 | Swope Park RangersSwope Park Ra |
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| 30 Oct 21 | r49        | Birmingham LegionBirmingham Le | 0 - 0 | Louisville CityLouisville Ci |
| 31 Oct 21 | r49        | Birmingham LegionBirmingham Le | 0 - 1 | Louisville CityLouisville Ci |
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| 07 Nov 21 | r00        | Birmingham LegionBirmingham Le | - | Pittsburgh RiverhoundsPittsburgh Ri |
| 14 Nov 21 | r00        | Tampa Bay RowdiesTampa Bay Row | 1 - 0 | Birmingham LegionBirmingham Le |