| 25 Apr 21 | r01   | Louisville CityLouisville Ci | 2 - 0 | Atlanta United IIAtlanta Unite |
| 25 Apr 21 | r01 | OKC EnergyOKC Energy | 1 - 3 | Tulsa RoughnecksTulsa Roughne |
| 01 May 21 | r01 | New York RB IINew York RB I | 2 - 3 | Hartford AthleticHartford Athl |
| 01 May 21 | r01 | Phoenix RisingPhoenix Risin | 4 - 1 | San Diego LoyalSan Diego Loy |
| 01 May 21 | r01 | LA Galaxy IILA Galaxy II | 0 - 1 | Sacramento RepublicSacramento Re |
| 02 May 21 | r01 | Birmingham LegionBirmingham Le | 0 - 1 | Indy ElevenIndy Eleven |
| 02 May 21 | r01 | Tampa Bay RowdiesTampa Bay Row | 3 - 0 | Charlotte IndependenceCharlotte Ind |
| 02 May 21 | r01 | Tulsa RoughnecksTulsa Roughne | 2 - 0 | Swope Park RangersSwope Park Ra |
| 02 May 21 | r01 | Rio Grande ValleyRio Grande Va | 1 - 0 | New Mexico UnitedNew Mexico Un |
| 02 May 21 | r01 | San AntonioSan Antonio | 3 - 0 | Colorado SpringsColorado Spri |
| |
| 02 May 21 | r02 | OKC EnergyOKC Energy | 0 - 1 | Atlanta United IIAtlanta Unite |
| 03 May 21 | r02 | Miami FCMiami FC | 2 - 1 | Loudoun UnitedLoudoun Unite |
| 06 May 21 | r02 | LA Galaxy IILA Galaxy II | 5 - 0 | Las Vegas LightsLas Vegas Lig |
| 07 May 21 | r02 | Rio Grande ValleyRio Grande Va | 1 - 0 | San Diego LoyalSan Diego Loy |
| 08 May 21 | r02 | New York RB IINew York RB I | 1 - 1 | Charleston BatteryCharleston Ba |
| 08 May 21 | r02 | Swope Park RangersSwope Park Ra | 1 - 1 | OKC EnergyOKC Energy |
| 09 May 21 | r02 | Indy ElevenIndy Eleven | 0 - 2 | Tulsa RoughnecksTulsa Roughne |
| |
| 09 May 21 | r03 | San AntonioSan Antonio | 2 - 2 | Real MonarchsReal Monarchs |
| |
| 09 May 21 | r02 | El Paso LocomotiveEl Paso Locom | 1 - 1 | New Mexico UnitedNew Mexico Un |
| |
| 09 May 21 | r03 | Phoenix RisingPhoenix Risin | 3 - 0 | Oakland RootsOakland Roots |
| |
| 10 May 21 | r02 | Miami FCMiami FC | 0 - 1 | Hartford AthleticHartford Athl |
| 10 May 21 | r02 | Tampa Bay RowdiesTampa Bay Row | 3 - 0 | Pittsburgh RiverhoundsPittsburgh Ri |
| |
| 10 May 21 | r03 | Louisville CityLouisville Ci | 1 - 1 | Birmingham LegionBirmingham Le |
| 10 May 21 | r03 | LA Galaxy IILA Galaxy II | 1 - 1 | Tacoma DefianceTacoma Defian |
| |
| 13 May 21 | r02 | Sacramento RepublicSacramento Re | 3 - 1 | Las Vegas LightsLas Vegas Lig |
| 14 May 21 | r02 | Tacoma DefianceTacoma Defian | 3 - 1 | San Diego LoyalSan Diego Loy |
| 14 May 21 | r02 | Charleston BatteryCharleston Ba | 0 - 3 | Charlotte IndependenceCharlotte Ind |
| |
| 15 May 21 | r03 | New York RB IINew York RB I | 0 - 1 | Miami FCMiami FC |
| 15 May 21 | r03 | Swope Park RangersSwope Park Ra | 0 - 4 | Colorado SpringsColorado Spri |
| |
| 15 May 21 | r02 | Real MonarchsReal Monarchs | 0 - 2 | LA Galaxy IILA Galaxy II |
| |
| 15 May 21 | r04 | Birmingham LegionBirmingham Le | 1 - 0 | Memphis 901Memphis 901 |
| |
| 16 May 21 | r02 | Hartford AthleticHartford Athl | 1 - 1 | Pittsburgh RiverhoundsPittsburgh Ri |
| |
| 16 May 21 | r04 | Tampa Bay RowdiesTampa Bay Row | 2 - 1 | Phoenix RisingPhoenix Risin |
| |
| 16 May 21 | r02 | New Mexico UnitedNew Mexico Un | 3 - 1 | Austin BoldAustin Bold |
| |
| 16 May 21 | r04 | Tacoma DefianceTacoma Defian | 1 - 0 | Orange County SCOrange County |
| 17 May 21 | r04 | Rio Grande ValleyRio Grande Va | 2 - 1 | San AntonioSan Antonio |
| 17 May 21 | r04 | OKC EnergyOKC Energy | 2 - 2 | Atlanta United IIAtlanta Unite |
| |
| 19 May 21 | r03 | Loudoun UnitedLoudoun Unite | 1 - 2 | New York RB IINew York RB I |
| |
| 20 May 21 | r04 | LA Galaxy IILA Galaxy II | 1 - 1 | Swope Park RangersSwope Park Ra |
| |
| 21 May 21 | r03 | Atlanta United IIAtlanta Unite | 5 - 0 | Tulsa RoughnecksTulsa Roughne |
| 22 May 21 | r03 | Colorado SpringsColorado Spri | 1 - 3 | New Mexico UnitedNew Mexico Un |
| |
| 22 May 21 | r05 | Real MonarchsReal Monarchs | 1 - 1 | Austin BoldAustin Bold |
| 23 May 21 | r05 | Indy ElevenIndy Eleven | 2 - 0 | Swope Park RangersSwope Park Ra |
| 23 May 21 | r05 | Pittsburgh RiverhoundsPittsburgh Ri | 0 - 1 | Charlotte IndependenceCharlotte Ind |
| 23 May 21 | r05 | San AntonioSan Antonio | 2 - 1 | Birmingham LegionBirmingham Le |
| 23 May 21 | r05 | El Paso LocomotiveEl Paso Locom | 1 - 0 | Rio Grande ValleyRio Grande Va |
| |
| 23 May 21 | r03 | Orange County SCOrange County | 1 - 0 | Sacramento RepublicSacramento Re |
| |
| 23 May 21 | r05 | Phoenix RisingPhoenix Risin | 5 - 1 | Las Vegas LightsLas Vegas Lig |
| |
| 23 May 21 | r06 | Charleston BatteryCharleston Ba | 2 - 2 | New York RB IINew York RB I |
| 23 May 21 | r06 | Atlanta United IIAtlanta Unite | 2 - 2 | Memphis 901Memphis 901 |
| |
| 24 May 21 | r05 | Louisville CityLouisville Ci | 2 - 1 | San Diego LoyalSan Diego Loy |
| 24 May 21 | r05 | Tampa Bay RowdiesTampa Bay Row | 2 - 1 | Miami FCMiami FC |
| |
| 24 May 21 | r06 | LA Galaxy IILA Galaxy II | 2 - 3 | Oakland RootsOakland Roots |
| 27 May 21 | r06 | Birmingham LegionBirmingham Le | 1 - 0 | OKC EnergyOKC Energy |
| 27 May 21 | r06 | Austin BoldAustin Bold | 2 - 0 | Real MonarchsReal Monarchs |
| 29 May 21 | r06 | New York RB IINew York RB I | 0 - 3 | Pittsburgh RiverhoundsPittsburgh Ri |
| 30 May 21 | r06 | Miami FCMiami FC | 2 - 1 | Charlotte IndependenceCharlotte Ind |
| 30 May 21 | r06 | Louisville CityLouisville Ci | 1 - 2 | Indy ElevenIndy Eleven |
| |
| 30 May 21 | r07 | OKC EnergyOKC Energy | 0 - 0 | Memphis 901Memphis 901 |
| 30 May 21 | r07 | San AntonioSan Antonio | 1 - 1 | Rio Grande ValleyRio Grande Va |
| 30 May 21 | r07 | New Mexico UnitedNew Mexico Un | 0 - 1 | Loudoun UnitedLoudoun Unite |
| 30 May 21 | r07  | Orange County SCOrange County | 3 - 4 | LA Galaxy IILA Galaxy II |
| |
| 30 May 21 | r03 | San Diego LoyalSan Diego Loy | 2 - 1 | Las Vegas LightsLas Vegas Lig |
| |
| 30 May 21 | r07 | Sacramento RepublicSacramento Re | 0 - 1 | Phoenix RisingPhoenix Risin |
| 30 May 21 | r07 | Atlanta United IIAtlanta Unite | 0 - 1 | Birmingham LegionBirmingham Le |
| 30 May 21 | r07 | Swope Park RangersSwope Park Ra | 0 - 0 | El Paso LocomotiveEl Paso Locom |
| 03 Jun 21 | r07 | Loudoun UnitedLoudoun Unite | 2 - 3 | Pittsburgh RiverhoundsPittsburgh Ri |
| 03 Jun 21 | r07 | New York RB IINew York RB I | 0 - 1 | Tampa Bay RowdiesTampa Bay Row |
| |
| 03 Jun 21 | r08 | Indy ElevenIndy Eleven | 1 - 1 | OKC EnergyOKC Energy |
| 03 Jun 21 | r08 | Swope Park RangersSwope Park Ra | 4 - 1 | Tulsa RoughnecksTulsa Roughne |
| 03 Jun 21 | r08 | Sacramento RepublicSacramento Re | 3 - 3 | Oakland RootsOakland Roots |
| 04 Jun 21 | r08 | Austin BoldAustin Bold | 0 - 1 | El Paso LocomotiveEl Paso Locom |
| 05 Jun 21 | r08 | Real MonarchsReal Monarchs | 0 - 1 | New Mexico UnitedNew Mexico Un |
| |
| 06 Jun 21 | r03 | Charlotte IndependenceCharlotte Ind | 1 - 0 | Tampa Bay RowdiesTampa Bay Row |
| |
| 06 Jun 21 | r08 | Indy ElevenIndy Eleven | 1 - 2 | Memphis 901Memphis 901 |
| 06 Jun 21 | r08 | Hartford AthleticHartford Athl | 7 - 0 | New York RB IINew York RB I |
| |
| 06 Jun 21 | r09 | Colorado SpringsColorado Spri | 1 - 1 | San AntonioSan Antonio |
| |
| 06 Jun 21 | r03 | Las Vegas LightsLas Vegas Lig | 2 - 0 | Tacoma DefianceTacoma Defian |
| |
| 06 Jun 21 | r09 | Phoenix RisingPhoenix Risin | 2 - 2 | San Diego LoyalSan Diego Loy |
| 06 Jun 21 | r09 | Sacramento RepublicSacramento Re | 1 - 3 | Orange County SCOrange County |
| 06 Jun 21 | r09 | Birmingham LegionBirmingham Le | 2 - 1 | Tulsa RoughnecksTulsa Roughne |
| |
| 06 Jun 21 | r03 | Pittsburgh RiverhoundsPittsburgh Ri | 0 - 1 | Austin BoldAustin Bold |
| |
| 06 Jun 21 | r09 | Miami FCMiami FC | 2 - 4 | Rio Grande ValleyRio Grande Va |
| 07 Jun 21 | r09 | Atlanta United IIAtlanta Unite | 1 - 0 | Louisville CityLouisville Ci |
| 09 Jun 21 | r09 | Loudoun UnitedLoudoun Unite | 0 - 1 | Charleston BatteryCharleston Ba |
| 10 Jun 21 | r09 | Atlanta United IIAtlanta Unite | 2 - 2 | Swope Park RangersSwope Park Ra |
| 10 Jun 21 | r09 | El Paso LocomotiveEl Paso Locom | 2 - 0 | Indy ElevenIndy Eleven |
| |
| 10 Jun 21 | r10 | Orange County SCOrange County | 1 - 1 | San Diego LoyalSan Diego Loy |
| 10 Jun 21 | r10 | Real MonarchsReal Monarchs | 2 - 0 | Sacramento RepublicSacramento Re |
| 12 Jun 21 | r10 | Tampa Bay RowdiesTampa Bay Row | 2 - 1 | Loudoun UnitedLoudoun Unite |
| 12 Jun 21 | r10 | Las Vegas LightsLas Vegas Lig | 1 - 1 | San AntonioSan Antonio |
| 13 Jun 21 | r10 | Pittsburgh RiverhoundsPittsburgh Ri | 1 - 1 | Miami FCMiami FC |
| 13 Jun 21 | r10 | Louisville CityLouisville Ci | 3 - 0 | Memphis 901Memphis 901 |
| |
| 13 Jun 21 | r11 | Rio Grande ValleyRio Grande Va | 1 - 0 | Real MonarchsReal Monarchs |
| |
| 13 Jun 21 | r10 | OKC EnergyOKC Energy | 1 - 2 | Birmingham LegionBirmingham Le |
| 13 Jun 21 | r10 | El Paso LocomotiveEl Paso Locom | 1 - 1 | Colorado SpringsColorado Spri |
| 13 Jun 21 | r10 | New Mexico UnitedNew Mexico Un | 0 - 0 | Austin BoldAustin Bold |
| |
| 13 Jun 21 | r11 | Orange County SCOrange County | 1 - 0 | Oakland RootsOakland Roots |
| 13 Jun 21 | r11 | Phoenix RisingPhoenix Risin | 3 - 0 | Tacoma DefianceTacoma Defian |
| 13 Jun 21 | r11 | San Diego LoyalSan Diego Loy | 2 - 1 | LA Galaxy IILA Galaxy II |
Team 2021 Schedules
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El Paso Locomotive
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Hartford Athletic
Indy Eleven
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Miami FC
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New Mexico United
Oakland Roots
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Phoenix Rising
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Sacramento Republic
San Antonio
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