| 06 May 21 | r02        | LA Galaxy IILA Galaxy II | 5 - 0 | Las Vegas LightsLas Vegas Lig |
| 13 May 21 | r02        | Sacramento RepublicSacramento Re | 3 - 1 | Las Vegas LightsLas Vegas Lig |
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| 23 May 21 | r05        | Phoenix RisingPhoenix Risin | 5 - 1 | Las Vegas LightsLas Vegas Lig |
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| 30 May 21 | r03        | San Diego LoyalSan Diego Loy | 2 - 1 | Las Vegas LightsLas Vegas Lig |
| 06 Jun 21 | r03        | Las Vegas LightsLas Vegas Lig | 2 - 0 | Tacoma DefianceTacoma Defian |
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| 12 Jun 21 | r10        | Las Vegas LightsLas Vegas Lig | 1 - 1 | San AntonioSan Antonio |
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| 17 Jun 21 | r11        | LA Galaxy IILA Galaxy II | 3 - 4 | Las Vegas LightsLas Vegas Lig |
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| 20 Jun 21 | r13        | Las Vegas LightsLas Vegas Lig | 1 - 3 | Orange County SCOrange County |
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| 26 Jun 21 | r14        | Las Vegas LightsLas Vegas Lig | 1 - 2 | San Diego LoyalSan Diego Loy |
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| 04 Jul 21 | r17        | Las Vegas LightsLas Vegas Lig | 1 - 0 | Tacoma DefianceTacoma Defian |
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| 11 Jul 21 | r19        | Oakland RootsOakland Roots | 1 - 2 | Las Vegas LightsLas Vegas Lig |
| 15 Jul 21 | r19        | Las Vegas LightsLas Vegas Lig | 1 - 2 | Sacramento RepublicSacramento Re |
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| 18 Jul 21 | r20        | El Paso LocomotiveEl Paso Locom | 1 - 0 | Las Vegas LightsLas Vegas Lig |
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| 24 Jul 21 | r21        | Real MonarchsReal Monarchs | 3 - 2 | Las Vegas LightsLas Vegas Lig |
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| 28 Jul 21 | r23        | Las Vegas LightsLas Vegas Lig | 3 - 1 | Orange County SCOrange County |
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| 08 Aug 21 | r26        | Las Vegas LightsLas Vegas Lig | 2 - 2 | Phoenix RisingPhoenix Risin |
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| 15 Aug 21 | r28        | Sacramento RepublicSacramento Re | 2 - 1 | Las Vegas LightsLas Vegas Lig |
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| 19 Aug 21 | r29        | San Diego LoyalSan Diego Loy | 5 - 1 | Las Vegas LightsLas Vegas Lig |
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| 22 Aug 21 | r30        | Las Vegas LightsLas Vegas Lig | 1 - 3 | Oakland RootsOakland Roots |
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| 28 Aug 21 | r31        | Las Vegas LightsLas Vegas Lig | 2 - 3 | LA Galaxy IILA Galaxy II |
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| 03 Sep 21 | r33        | Tacoma DefianceTacoma Defian | 2 - 1 | Las Vegas LightsLas Vegas Lig |
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| 06 Sep 21 | r34        | Las Vegas LightsLas Vegas Lig | 1 - 3 | Sacramento RepublicSacramento Re |
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| 09 Sep 21 | r35        | Las Vegas LightsLas Vegas Lig | 0 - 1 | Oakland RootsOakland Roots |
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| 12 Sep 21 | r36        | Orange County SCOrange County | 3 - 0 | Las Vegas LightsLas Vegas Lig |
| 16 Sep 21 | r36        | Phoenix RisingPhoenix Risin | 4 - 1 | Las Vegas LightsLas Vegas Lig |
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| 26 Sep 21 | r39        | Las Vegas LightsLas Vegas Lig | 2 - 4 | San Diego LoyalSan Diego Loy |
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| 03 Oct 21 | r41        | Oakland RootsOakland Roots | 2 - 2 | Las Vegas LightsLas Vegas Lig |
| |
| 09 Oct 21 | r43        | Las Vegas LightsLas Vegas Lig | 0 - 1 | LA Galaxy IILA Galaxy II |
| |
| 14 Oct 21 | r40        | Tacoma DefianceTacoma Defian | 0 - 1 | Las Vegas LightsLas Vegas Lig |
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| 16 Oct 21 | r45        | Las Vegas LightsLas Vegas Lig | 3 - 6 | Phoenix RisingPhoenix Risin |
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| 24 Oct 21 | r47        | Orange County SCOrange County | 2 - 1 | Las Vegas LightsLas Vegas Lig |
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| 31 Oct 21 | r49        | Las Vegas LightsLas Vegas Lig | 1 - 2 | Tampa Bay RowdiesTampa Bay Row |