| 25 Apr 21 | r01        | OKC EnergyOKC Energy | 1 - 3 | Tulsa RoughnecksTulsa Roughne |
| 02 May 21 | r01        | Tulsa RoughnecksTulsa Roughne | 2 - 0 | Swope Park RangersSwope Park Ra |
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| 09 May 21 | r02        | Indy ElevenIndy Eleven | 0 - 2 | Tulsa RoughnecksTulsa Roughne |
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| 21 May 21 | r03        | Atlanta United IIAtlanta Unite | 5 - 0 | Tulsa RoughnecksTulsa Roughne |
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| 03 Jun 21 | r08        | Swope Park RangersSwope Park Ra | 4 - 1 | Tulsa RoughnecksTulsa Roughne |
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| 06 Jun 21 | r09        | Birmingham LegionBirmingham Le | 2 - 1 | Tulsa RoughnecksTulsa Roughne |
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| 17 Jun 21 | r12        | Tulsa RoughnecksTulsa Roughne | 4 - 3 | Swope Park RangersSwope Park Ra |
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| 20 Jun 21 | r13        | Tulsa RoughnecksTulsa Roughne | 2 - 3 | Louisville CityLouisville Ci |
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| 26 Jun 21 | r14        | Rio Grande ValleyRio Grande Va | 1 - 2 | Tulsa RoughnecksTulsa Roughne |
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| 03 Jul 21 | r16        | OKC EnergyOKC Energy | 0 - 0 | Tulsa RoughnecksTulsa Roughne |
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| 10 Jul 21 | r19        | Tulsa RoughnecksTulsa Roughne | 3 - 2 | Louisville CityLouisville Ci |
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| 18 Jul 21 | r20        | Tulsa RoughnecksTulsa Roughne | 1 - 2 | OKC EnergyOKC Energy |
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| 25 Jul 21 | r22        | Memphis 901Memphis 901 | 1 - 0 | Tulsa RoughnecksTulsa Roughne |
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| 29 Jul 21 | r23        | Atlanta United IIAtlanta Unite | 2 - 1 | Tulsa RoughnecksTulsa Roughne |
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| 05 Aug 21 | r25        | Tulsa RoughnecksTulsa Roughne | 0 - 2 | Indy ElevenIndy Eleven |
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| 08 Aug 21 | r26        | Tulsa RoughnecksTulsa Roughne | 3 - 1 | Birmingham LegionBirmingham Le |
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| 15 Aug 21 | r27        | Louisville CityLouisville Ci | 2 - 1 | Tulsa RoughnecksTulsa Roughne |
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| 22 Aug 21 | r30        | Birmingham LegionBirmingham Le | 1 - 2 | Tulsa RoughnecksTulsa Roughne |
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| 26 Aug 21 | r31        | Tulsa RoughnecksTulsa Roughne | 2 - 1 | Memphis 901Memphis 901 |
| 29 Aug 21 | r31        | Tulsa RoughnecksTulsa Roughne | 3 - 1 | Atlanta United IIAtlanta Unite |
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| 04 Sep 21 | r33        | Louisville CityLouisville Ci | 0 - 1 | Tulsa RoughnecksTulsa Roughne |
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| 09 Sep 21 | r35        | Tulsa RoughnecksTulsa Roughne | 2 - 1 | Indy ElevenIndy Eleven |
| 12 Sep 21 | r35        | Tulsa RoughnecksTulsa Roughne | 1 - 1 | Birmingham LegionBirmingham Le |
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| 19 Sep 21 | r37        | Tulsa RoughnecksTulsa Roughne | 0 - 1 | Austin BoldAustin Bold |
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| 25 Sep 21 | r39        | Swope Park RangersSwope Park Ra | 1 - 1 | Tulsa RoughnecksTulsa Roughne |
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| 03 Oct 21 | r41        | Tulsa RoughnecksTulsa Roughne | 0 - 3 | Memphis 901Memphis 901 |
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| 10 Oct 21 | r43        | Tulsa RoughnecksTulsa Roughne | 1 - 2 | El Paso LocomotiveEl Paso Locom |
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| 17 Oct 21 | r46        | San AntonioSan Antonio | 1 - 1 | Tulsa RoughnecksTulsa Roughne |
| 21 Oct 21 | r46        | Tulsa RoughnecksTulsa Roughne | 4 - 0 | Atlanta United IIAtlanta Unite |
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| 24 Oct 21 | r47        | Indy ElevenIndy Eleven | 1 - 1 | Tulsa RoughnecksTulsa Roughne |
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| 28 Oct 21 | r48        | Memphis 901Memphis 901 | 3 - 2 | Tulsa RoughnecksTulsa Roughne |
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| 31 Oct 21 | r49        | Tulsa RoughnecksTulsa Roughne | 2 - 0 | OKC EnergyOKC Energy |
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| 06 Nov 21 | r00        | Tampa Bay RowdiesTampa Bay Row | 6 - 2 | Tulsa RoughnecksTulsa Roughne |