| 24 Jul 21 | r01    | FC Lausanne-SportFC Lausanne-S | 1 - 2 | St. GallenSt. Gallen |
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| 31 Jul 21 | r02 | ZurichZurich | 3 - 1 | FC Lausanne-SportFC Lausanne-S |
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| 07 Aug 21 | r03  | GrasshoppersGrasshoppers | 3 - 1 | FC Lausanne-SportFC Lausanne-S |
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| 22 Aug 21 | r04 | FC Lausanne-SportFC Lausanne-S | 2 - 2 | FC BaselFC Basel |
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| 29 Aug 21 | r05 | Lucerne Lucerne | 1 - 1 | FC Lausanne-SportFC Lausanne-S |
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| 12 Sep 21 | r06 | FC Lausanne-SportFC Lausanne-S | 1 - 1 | FC SionFC Sion |
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| 22 Sep 21 | r07 | FC Lausanne-SportFC Lausanne-S | 1 - 6 | Young BoysYoung Boys |
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| 25 Sep 21 | r08 | ServetteServette | 1 - 1 | FC Lausanne-SportFC Lausanne-S |
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| 02 Oct 21 | r09 | LuganoLugano | 2 - 0 | FC Lausanne-SportFC Lausanne-S |
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| 17 Oct 21 | r10 | FC Lausanne-SportFC Lausanne-S | 3 - 1 | GrasshoppersGrasshoppers |
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| 23 Oct 21 | r11 | Young BoysYoung Boys | 3 - 2 | FC Lausanne-SportFC Lausanne-S |
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| 31 Oct 21 | r12 | FC Lausanne-SportFC Lausanne-S | 1 - 1 | Lucerne Lucerne |
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| 07 Nov 21 | r13 | FC Lausanne-SportFC Lausanne-S | 0 - 2 | LuganoLugano |
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| 21 Nov 21 | r14 | St. GallenSt. Gallen | 0 - 1 | FC Lausanne-SportFC Lausanne-S |
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| 28 Nov 21 | r15 | FC Lausanne-SportFC Lausanne-S | 0 - 3 | ServetteServette |
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| 05 Dec 21 | r16 | FC BaselFC Basel | 1 - 1 | FC Lausanne-SportFC Lausanne-S |
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| 11 Dec 21 | r17 | FC Lausanne-SportFC Lausanne-S | 1 - 3 | ZurichZurich |
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| 19 Dec 21 | r18 | FC SionFC Sion | 2 - 0 | FC Lausanne-SportFC Lausanne-S |
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| 30 Jan 22 | r19 | FC Lausanne-SportFC Lausanne-S | 1 - 5 | St. GallenSt. Gallen |
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| 05 Feb 22 | r20 | ServetteServette | 1 - 0 | FC Lausanne-SportFC Lausanne-S |
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| 12 Feb 22 | r21 | FC Lausanne-SportFC Lausanne-S | 0 - 2 | GrasshoppersGrasshoppers |
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| 19 Feb 22 | r22 | FC BaselFC Basel | 3 - 0 | FC Lausanne-SportFC Lausanne-S |
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| 27 Feb 22 | r23 | FC Lausanne-SportFC Lausanne-S | 1 - 2 | Lucerne Lucerne |
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| 02 Mar 22 | r24 | FC SionFC Sion | 1 - 0 | FC Lausanne-SportFC Lausanne-S |
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| 05 Mar 22 | r25 | FC Lausanne-SportFC Lausanne-S | 0 - 2 | ZurichZurich |
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| 13 Mar 22 | r26 | FC Lausanne-SportFC Lausanne-S | 2 - 2 | Young BoysYoung Boys |
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| 20 Mar 22 | r27 | LuganoLugano | 3 - 1 | FC Lausanne-SportFC Lausanne-S |
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| 03 Apr 22 | r28 | FC Lausanne-SportFC Lausanne-S | 4 - 1 | ServetteServette |
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| 09 Apr 22 | r29 | Young BoysYoung Boys | 2 - 2 | FC Lausanne-SportFC Lausanne-S |
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| 18 Apr 22 | r30 | FC Lausanne-SportFC Lausanne-S | 4 - 1 | LuganoLugano |
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| 24 Apr 22 | r31 | GrasshoppersGrasshoppers | 3 - 1 | FC Lausanne-SportFC Lausanne-S |
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| 01 May 22 | r32 | Lucerne Lucerne | 3 - 0 | FC Lausanne-SportFC Lausanne-S |
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| 08 May 22 | r33 | FC Lausanne-SportFC Lausanne-S | 0 - 0 | FC BaselFC Basel |
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| 12 May 22 | r34 | ZurichZurich | 2 - 2 | FC Lausanne-SportFC Lausanne-S |
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| 19 May 22 | r35 | FC Lausanne-SportFC Lausanne-S | 1 - 2 | FC SionFC Sion |
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| 22 May 22 | r36 | St. GallenSt. Gallen | 4 - 0 | FC Lausanne-SportFC Lausanne-S |
Team 2021-2022 Schedules
Basel
Grasshoppers
Lausanne-Sport
Lugano
Luzern
Servette
Sion
St. Gallen
Thun
Winterthur
Young Boys
Zürich
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