| 16 Aug 21 | r01        | Gżira UnitedGżira United | 1 - 3 | Hibernians FCHibernians FC |
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| 22 Aug 21 | r02        | Santa Lucia FCSanta Lucia F | 1 - 1 | Gżira UnitedGżira United |
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| 11 Sep 21 | r03        | Gżira UnitedGżira United | 1 - 1 | SliemaSliema |
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| 18 Sep 21 | r04        | VallettaValletta | 0 - 2 | Gżira UnitedGżira United |
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| 26 Sep 21 | r05        | Gżira UnitedGżira United | 1 - 1 | BirkirkaraBirkirkara |
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| 16 Oct 21 | r06        | Ħamrun SpartansĦamrun Sparta | 0 - 1 | Gżira UnitedGżira United |
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| 23 Oct 21 | r07        | Gżira UnitedGżira United | 1 - 2 | Balzan FCBalzan FC |
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| 31 Oct 21 | r08        | Floriana FCFloriana FC | 2 - 1 | Gżira UnitedGżira United |
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| 20 Nov 21 | r09        | Mosta FCMosta FC | 2 - 2 | Gżira UnitedGżira United |
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| 28 Nov 21 | r10        | Gżira UnitedGżira United | 3 - 2 | Gudja UnitedGudja United |
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| 04 Dec 21 | r11        | Sirens FCSirens FC | 1 - 3 | Gżira UnitedGżira United |
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| 12 Dec 21 | r12        | Hibernians FCHibernians FC | 3 - 1 | Gżira UnitedGżira United |
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| 18 Dec 21 | r13        | Gżira UnitedGżira United | 2 - 2 | Santa Lucia FCSanta Lucia F |
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| 18 Jan 22 | r14        | SliemaSliema | 1 - 3 | Gżira UnitedGżira United |
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| 23 Jan 22 | r15        | Gżira UnitedGżira United | 1 - 1 | VallettaValletta |
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| 30 Jan 22 | r16        | BirkirkaraBirkirkara | 1 - 0 | Gżira UnitedGżira United |
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| 05 Feb 22 | r17        | Gżira UnitedGżira United | 4 - 1 | Ħamrun SpartansĦamrun Sparta |
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| 12 Feb 22 | r18        | Balzan FCBalzan FC | 1 - 3 | Gżira UnitedGżira United |
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| 20 Feb 22 | r19        | Gżira UnitedGżira United | 1 - 2 | Floriana FCFloriana FC |
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| 27 Feb 22 | r20        | Gżira UnitedGżira United | 3 - 4 | Mosta FCMosta FC |
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| 05 Mar 22 | r21        | Gudja UnitedGudja United | 1 - 2 | Gżira UnitedGżira United |
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| 12 Mar 22 | r22        | Gżira UnitedGżira United | 2 - 1 | Sirens FCSirens FC |
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| 03 Apr 22 | r01        | Floriana FCFloriana FC | 0 - 1 | Gżira UnitedGżira United |
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| 10 Apr 22 | r02        | Gżira UnitedGżira United | 1 - 1 | BirkirkaraBirkirkara |
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| 24 Apr 22 | r03        | Ħamrun SpartansĦamrun Sparta | 2 - 0 | Gżira UnitedGżira United |
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| 01 May 22 | r04        | Gżira UnitedGżira United | 3 - 1 | Gudja UnitedGudja United |
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| 07 May 22 | r05        | Gżira UnitedGżira United | 2 - 1 | Hibernians FCHibernians FC |