| 12 Aug 21 | r01  | Balzan FCBalzan FC | 1 - 0 | SliemaSliema |
| 13 Aug 21 | r01 | Gudja UnitedGudja United | 0 - 1 | Sirens FCSirens FC |
| 13 Aug 21 | r01 | Ħamrun SpartansĦamrun Sparta | 1 - 2 | VallettaValletta |
| 14 Aug 21 | r01 | Mosta FCMosta FC | 0 - 3 | BirkirkaraBirkirkara |
| 14 Aug 21 | r01 | Floriana FCFloriana FC | 2 - 2 | Santa Lucia FCSanta Lucia F |
| 16 Aug 21 | r01 | Gżira UnitedGżira United | 1 - 3 | Hibernians FCHibernians FC |
| |
| 20 Aug 21 | r02 | Sirens FCSirens FC | 1 - 1 | Mosta FCMosta FC |
| 20 Aug 21 | r02 | SliemaSliema | 0 - 0 | Floriana FCFloriana FC |
| 21 Aug 21 | r02 | BirkirkaraBirkirkara | 2 - 1 | Ħamrun SpartansĦamrun Sparta |
| 21 Aug 21 | r02 | VallettaValletta | 1 - 0 | Balzan FCBalzan FC |
| 22 Aug 21 | r02 | Santa Lucia FCSanta Lucia F | 1 - 1 | Gżira UnitedGżira United |
| 22 Aug 21 | r02 | Hibernians FCHibernians FC | 2 - 1 | Gudja UnitedGudja United |
| |
| 11 Sep 21 | r03 | Mosta FCMosta FC | 1 - 2 | Ħamrun SpartansĦamrun Sparta |
| 11 Sep 21 | r03 | Floriana FCFloriana FC | 3 - 0 | VallettaValletta |
| 11 Sep 21 | r03 | Gżira UnitedGżira United | 1 - 1 | SliemaSliema |
| 12 Sep 21 | r03 | Sirens FCSirens FC | 1 - 3 | Hibernians FCHibernians FC |
| 12 Sep 21 | r03 | Balzan FCBalzan FC | 1 - 2 | BirkirkaraBirkirkara |
| 12 Sep 21 | r03 | Gudja UnitedGudja United | 2 - 2 | Santa Lucia FCSanta Lucia F |
| |
| 18 Sep 21 | r04 | Santa Lucia FCSanta Lucia F | 1 - 3 | Sirens FCSirens FC |
| 18 Sep 21 | r04 | VallettaValletta | 0 - 2 | Gżira UnitedGżira United |
| 18 Sep 21 | r04 | Hibernians FCHibernians FC | 3 - 2 | Mosta FCMosta FC |
| 19 Sep 21 | r04 | BirkirkaraBirkirkara | 1 - 1 | Floriana FCFloriana FC |
| 19 Sep 21 | r04 | SliemaSliema | 2 - 3 | Gudja UnitedGudja United |
| 19 Sep 21 | r04 | Ħamrun SpartansĦamrun Sparta | 0 - 1 | Balzan FCBalzan FC |
| |
| 25 Sep 21 | r05 | Gudja UnitedGudja United | 2 - 0 | VallettaValletta |
| 25 Sep 21 | r05 | Floriana FCFloriana FC | 1 - 2 | Ħamrun SpartansĦamrun Sparta |
| 25 Sep 21 | r05 | Hibernians FCHibernians FC | 1 - 1 | Santa Lucia FCSanta Lucia F |
| 26 Sep 21 | r05 | Gżira UnitedGżira United | 1 - 1 | BirkirkaraBirkirkara |
| 26 Sep 21 | r05 | Sirens FCSirens FC | 2 - 2 | SliemaSliema |
| 26 Sep 21 | r05 | Mosta FCMosta FC | 2 - 1 | Balzan FCBalzan FC |
| |
| 16 Oct 21 | r06 | Balzan FCBalzan FC | 1 - 2 | Floriana FCFloriana FC |
| 16 Oct 21 | r06 | Ħamrun SpartansĦamrun Sparta | 0 - 1 | Gżira UnitedGżira United |
| 16 Oct 21 | r06 | BirkirkaraBirkirkara | 2 - 0 | Gudja UnitedGudja United |
| 17 Oct 21 | r06 | SliemaSliema | 0 - 3 | Hibernians FCHibernians FC |
| 17 Oct 21 | r06 | VallettaValletta | 3 - 1 | Sirens FCSirens FC |
| 17 Oct 21 | r06 | Santa Lucia FCSanta Lucia F | 2 - 2 | Mosta FCMosta FC |
| |
| 23 Oct 21 | r07 | Gudja UnitedGudja United | 1 - 3 | Ħamrun SpartansĦamrun Sparta |
| 23 Oct 21 | r07 | Mosta FCMosta FC | 1 - 1 | Floriana FCFloriana FC |
| 23 Oct 21 | r07 | Gżira UnitedGżira United | 1 - 2 | Balzan FCBalzan FC |
| 24 Oct 21 | r07 | Santa Lucia FCSanta Lucia F | 0 - 0 | SliemaSliema |
| 24 Oct 21 | r07 | Hibernians FCHibernians FC | 1 - 1 | VallettaValletta |
| 24 Oct 21 | r07 | Sirens FCSirens FC | 3 - 2 | BirkirkaraBirkirkara |
| |
| 30 Oct 21 | r08 | BirkirkaraBirkirkara | 1 - 1 | Hibernians FCHibernians FC |
| 30 Oct 21 | r08 | VallettaValletta | 5 - 3 | Santa Lucia FCSanta Lucia F |
| 30 Oct 21 | r08 | Ħamrun SpartansĦamrun Sparta | 1 - 0 | Sirens FCSirens FC |
| 31 Oct 21 | r08 | Balzan FCBalzan FC | 1 - 0 | Gudja UnitedGudja United |
| 31 Oct 21 | r08 | Floriana FCFloriana FC | 2 - 1 | Gżira UnitedGżira United |
| 31 Oct 21 | r08 | SliemaSliema | 2 - 3 | Mosta FCMosta FC |
| |
| 20 Nov 21 | r09 | Mosta FCMosta FC | 2 - 2 | Gżira UnitedGżira United |
| 20 Nov 21 | r09 | SliemaSliema | 2 - 1 | VallettaValletta |
| 20 Nov 21 | r09 | Gudja UnitedGudja United | 0 - 1 | Floriana FCFloriana FC |
| 21 Nov 21 | r09 | Santa Lucia FCSanta Lucia F | 2 - 0 | BirkirkaraBirkirkara |
| 21 Nov 21 | r09 | Sirens FCSirens FC | 1 - 6 | Balzan FCBalzan FC |
| 21 Nov 21 | r09 | Hibernians FCHibernians FC | 1 - 0 | Ħamrun SpartansĦamrun Sparta |
| |
| 27 Nov 21 | r10 | Floriana FCFloriana FC | 1 - 2 | Sirens FCSirens FC |
| 27 Nov 21 | r10 | BirkirkaraBirkirkara | 2 - 0 | SliemaSliema |
| 27 Nov 21 | r10 | VallettaValletta | 3 - 1 | Mosta FCMosta FC |
| 28 Nov 21 | r10 | Gżira UnitedGżira United | 3 - 2 | Gudja UnitedGudja United |
| 28 Nov 21 | r10 | Ħamrun SpartansĦamrun Sparta | 3 - 0 | Santa Lucia FCSanta Lucia F |
| 28 Nov 21 | r10 | Balzan FCBalzan FC | 1 - 2 | Hibernians FCHibernians FC |
| |
| 04 Dec 21 | r11 | Mosta FCMosta FC | 0 - 3 | Gudja UnitedGudja United |
| 04 Dec 21 | r11 | VallettaValletta | 0 - 0 | BirkirkaraBirkirkara |
| 04 Dec 21 | r11 | Sirens FCSirens FC | 1 - 3 | Gżira UnitedGżira United |
| 05 Dec 21 | r11 | SliemaSliema | 0 - 2 | Ħamrun SpartansĦamrun Sparta |
| 05 Dec 21 | r11 | Hibernians FCHibernians FC | 0 - 0 | Floriana FCFloriana FC |
| 05 Dec 21 | r11 | Santa Lucia FCSanta Lucia F | 3 - 3 | Balzan FCBalzan FC |
| |
| 11 Dec 21 | r12 | Santa Lucia FCSanta Lucia F | 1 - 3 | Floriana FCFloriana FC |
| 12 Dec 21 | r12 | BirkirkaraBirkirkara | 2 - 2 | Mosta FCMosta FC |
| 12 Dec 21 | r12 | Hibernians FCHibernians FC | 3 - 1 | Gżira UnitedGżira United |
| 13 Dec 21 | r12 | Sirens FCSirens FC | 0 - 0 | Gudja UnitedGudja United |
| 13 Dec 21 | r12 | VallettaValletta | 0 - 1 | Ħamrun SpartansĦamrun Sparta |
| |
| 18 Dec 21 | r13 | Gżira UnitedGżira United | 2 - 2 | Santa Lucia FCSanta Lucia F |
| 18 Dec 21 | r13 | Mosta FCMosta FC | 2 - 3 | Sirens FCSirens FC |
| 19 Dec 21 | r13 | Gudja UnitedGudja United | 1 - 2 | Hibernians FCHibernians FC |
| 19 Dec 21 | r13 | Floriana FCFloriana FC | 2 - 0 | SliemaSliema |
| 19 Dec 21 | r13 | Balzan FCBalzan FC | 2 - 1 | VallettaValletta |
| |
| 17 Jan 22 | r14 | VallettaValletta | 0 - 2 | Floriana FCFloriana FC |
| 17 Jan 22 | r14 | Ħamrun SpartansĦamrun Sparta | 2 - 1 | Mosta FCMosta FC |
| 18 Jan 22 | r14 | SliemaSliema | 1 - 3 | Gżira UnitedGżira United |
| 18 Jan 22 | r14 | Hibernians FCHibernians FC | 1 - 1 | Sirens FCSirens FC |
| 19 Jan 22 | r14 | Santa Lucia FCSanta Lucia F | 0 - 3 | Gudja UnitedGudja United |
| 19 Jan 22 | r14 | BirkirkaraBirkirkara | 3 - 2 | Balzan FCBalzan FC |
| |
| 22 Jan 22 | r15 | Balzan FCBalzan FC | 2 - 2 | Ħamrun SpartansĦamrun Sparta |
| 22 Jan 22 | r15 | Mosta FCMosta FC | 1 - 1 | Hibernians FCHibernians FC |
| 22 Jan 22 | r15 | Gudja UnitedGudja United | 1 - 0 | SliemaSliema |
| 23 Jan 22 | r15 | Gżira UnitedGżira United | 1 - 1 | VallettaValletta |
| 23 Jan 22 | r15 | Sirens FCSirens FC | 2 - 1 | Santa Lucia FCSanta Lucia F |
| 23 Jan 22 | r15 | Floriana FCFloriana FC | 1 - 0 | BirkirkaraBirkirkara |
| |
| 26 Jan 22 | r12 | SliemaSliema | 1 - 0 | Balzan FCBalzan FC |
| |
| 26 Jan 22 | r13 | Ħamrun SpartansĦamrun Sparta | 0 - 0 | BirkirkaraBirkirkara |
| |
| 29 Jan 22 | r16 | Santa Lucia FCSanta Lucia F | 0 - 0 | Hibernians FCHibernians FC |
| 29 Jan 22 | r16 | SliemaSliema | 1 - 0 | Sirens FCSirens FC |
| 29 Jan 22 | r16 | Balzan FCBalzan FC | 2 - 3 | Mosta FCMosta FC |
| 30 Jan 22 | r16 | Ħamrun SpartansĦamrun Sparta | 2 - 2 | Floriana FCFloriana FC |
| 30 Jan 22 | r16 | VallettaValletta | 1 - 3 | Gudja UnitedGudja United |
| 30 Jan 22 | r16 | BirkirkaraBirkirkara | 1 - 0 | Gżira UnitedGżira United |
| |
| 05 Feb 22 | r17 | Mosta FCMosta FC | 1 - 0 | Santa Lucia FCSanta Lucia F |
| 05 Feb 22 | r17 | Gżira UnitedGżira United | 4 - 1 | Ħamrun SpartansĦamrun Sparta |
| 05 Feb 22 | r17 | Hibernians FCHibernians FC | 1 - 0 | SliemaSliema |
| 06 Feb 22 | r17 | Floriana FCFloriana FC | 2 - 1 | Balzan FCBalzan FC |
Team 2021-2022 Schedules
Balzan
Birkirkara
Birżebbuġa St. Peter's
Floriana
Gżira United
Ħamrun Spartans
Hibernians
Marsaxlokk
Mosta
Sliema Wanderers
Valletta
Żabbar St Patrick
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