| 13 Aug 21 | r01  | Ħamrun SpartansĦamrun Sparta | 1 - 2 | VallettaValletta |
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| 21 Aug 21 | r02 | BirkirkaraBirkirkara | 2 - 1 | Ħamrun SpartansĦamrun Sparta |
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| 11 Sep 21 | r03 | Mosta FCMosta FC | 1 - 2 | Ħamrun SpartansĦamrun Sparta |
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| 19 Sep 21 | r04 | Ħamrun SpartansĦamrun Sparta | 0 - 1 | Balzan FCBalzan FC |
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| 25 Sep 21 | r05 | Floriana FCFloriana FC | 1 - 2 | Ħamrun SpartansĦamrun Sparta |
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| 16 Oct 21 | r06 | Ħamrun SpartansĦamrun Sparta | 0 - 1 | Gżira UnitedGżira United |
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| 23 Oct 21 | r07 | Gudja UnitedGudja United | 1 - 3 | Ħamrun SpartansĦamrun Sparta |
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| 30 Oct 21 | r08 | Ħamrun SpartansĦamrun Sparta | 1 - 0 | Sirens FCSirens FC |
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| 21 Nov 21 | r09 | Hibernians FCHibernians FC | 1 - 0 | Ħamrun SpartansĦamrun Sparta |
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| 28 Nov 21 | r10 | Ħamrun SpartansĦamrun Sparta | 3 - 0 | Santa Lucia FCSanta Lucia F |
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| 05 Dec 21 | r11 | SliemaSliema | 0 - 2 | Ħamrun SpartansĦamrun Sparta |
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| 13 Dec 21 | r12 | VallettaValletta | 0 - 1 | Ħamrun SpartansĦamrun Sparta |
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| 17 Jan 22 | r14 | Ħamrun SpartansĦamrun Sparta | 2 - 1 | Mosta FCMosta FC |
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| 22 Jan 22 | r15 | Balzan FCBalzan FC | 2 - 2 | Ħamrun SpartansĦamrun Sparta |
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| 26 Jan 22 | r13 | Ħamrun SpartansĦamrun Sparta | 0 - 0 | BirkirkaraBirkirkara |
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| 30 Jan 22 | r16 | Ħamrun SpartansĦamrun Sparta | 2 - 2 | Floriana FCFloriana FC |
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| 05 Feb 22 | r17 | Gżira UnitedGżira United | 4 - 1 | Ħamrun SpartansĦamrun Sparta |
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| 13 Feb 22 | r18 | Ħamrun SpartansĦamrun Sparta | 0 - 1 | Gudja UnitedGudja United |
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| 19 Feb 22 | r19 | Sirens FCSirens FC | 1 - 1 | Ħamrun SpartansĦamrun Sparta |
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| 26 Feb 22 | r20 | Ħamrun SpartansĦamrun Sparta | 0 - 0 | Hibernians FCHibernians FC |
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| 06 Mar 22 | r21 | Santa Lucia FCSanta Lucia F | 0 - 1 | Ħamrun SpartansĦamrun Sparta |
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| 11 Mar 22 | r22 | Ħamrun SpartansĦamrun Sparta | 3 - 1 | SliemaSliema |
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| 04 Apr 22 | r01 | Ħamrun SpartansĦamrun Sparta | 2 - 1 | Hibernians FCHibernians FC |
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| 10 Apr 22 | r02 | Gudja UnitedGudja United | 1 - 0 | Ħamrun SpartansĦamrun Sparta |
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| 24 Apr 22 | r03 | Ħamrun SpartansĦamrun Sparta | 2 - 0 | Gżira UnitedGżira United |
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| 30 Apr 22 | r04 | Floriana FCFloriana FC | 0 - 0 | Ħamrun SpartansĦamrun Sparta |
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| 07 May 22 | r05 | BirkirkaraBirkirkara | 0 - 1 | Ħamrun SpartansĦamrun Sparta |
Team 2021-2022 Schedules
Balzan
Birkirkara
Birżebbuġa St. Peter's
Floriana
Gżira United
Ħamrun Spartans
Hibernians
Marsaxlokk
Mosta
Sliema Wanderers
Valletta
Żabbar St Patrick
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