| 16 Aug 21 | r01  | Gżira UnitedGżira United | 1 - 3 | Hibernians FCHibernians FC |
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| 22 Aug 21 | r02 | Hibernians FCHibernians FC | 2 - 1 | Gudja UnitedGudja United |
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| 12 Sep 21 | r03 | Sirens FCSirens FC | 1 - 3 | Hibernians FCHibernians FC |
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| 18 Sep 21 | r04 | Hibernians FCHibernians FC | 3 - 2 | Mosta FCMosta FC |
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| 25 Sep 21 | r05 | Hibernians FCHibernians FC | 1 - 1 | Santa Lucia FCSanta Lucia F |
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| 17 Oct 21 | r06 | SliemaSliema | 0 - 3 | Hibernians FCHibernians FC |
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| 24 Oct 21 | r07 | Hibernians FCHibernians FC | 1 - 1 | VallettaValletta |
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| 30 Oct 21 | r08 | BirkirkaraBirkirkara | 1 - 1 | Hibernians FCHibernians FC |
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| 21 Nov 21 | r09 | Hibernians FCHibernians FC | 1 - 0 | Ħamrun SpartansĦamrun Sparta |
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| 28 Nov 21 | r10 | Balzan FCBalzan FC | 1 - 2 | Hibernians FCHibernians FC |
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| 05 Dec 21 | r11 | Hibernians FCHibernians FC | 0 - 0 | Floriana FCFloriana FC |
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| 12 Dec 21 | r12 | Hibernians FCHibernians FC | 3 - 1 | Gżira UnitedGżira United |
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| 19 Dec 21 | r13 | Gudja UnitedGudja United | 1 - 2 | Hibernians FCHibernians FC |
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| 18 Jan 22 | r14 | Hibernians FCHibernians FC | 1 - 1 | Sirens FCSirens FC |
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| 22 Jan 22 | r15 | Mosta FCMosta FC | 1 - 1 | Hibernians FCHibernians FC |
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| 29 Jan 22 | r16 | Santa Lucia FCSanta Lucia F | 0 - 0 | Hibernians FCHibernians FC |
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| 05 Feb 22 | r17 | Hibernians FCHibernians FC | 1 - 0 | SliemaSliema |
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| 12 Feb 22 | r18 | VallettaValletta | 1 - 4 | Hibernians FCHibernians FC |
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| 19 Feb 22 | r19 | Hibernians FCHibernians FC | 2 - 3 | BirkirkaraBirkirkara |
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| 26 Feb 22 | r20 | Ħamrun SpartansĦamrun Sparta | 0 - 0 | Hibernians FCHibernians FC |
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| 05 Mar 22 | r21 | Hibernians FCHibernians FC | 1 - 0 | Balzan FCBalzan FC |
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| 12 Mar 22 | r22 | Floriana FCFloriana FC | 1 - 4 | Hibernians FCHibernians FC |
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| 04 Apr 22 | r01 | Ħamrun SpartansĦamrun Sparta | 2 - 1 | Hibernians FCHibernians FC |
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| 09 Apr 22 | r02 | Hibernians FCHibernians FC | 0 - 0 | Floriana FCFloriana FC |
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| 24 Apr 22 | r03 | Gudja UnitedGudja United | 0 - 2 | Hibernians FCHibernians FC |
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| 01 May 22 | r04 | Hibernians FCHibernians FC | 3 - 1 | BirkirkaraBirkirkara |
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| 07 May 22 | r05 | Gżira UnitedGżira United | 2 - 1 | Hibernians FCHibernians FC |
Team 2021-2022 Schedules
Balzan
Birkirkara
Birżebbuġa St. Peter's
Floriana
Gżira United
Ħamrun Spartans
Hibernians
Marsaxlokk
Mosta
Sliema Wanderers
Valletta
Żabbar St Patrick
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