| 06 Dec 24 | r01     | Bath RugbyBath Rugby | 20 - 24 | Stade RochelaisStade Rochela |
| 07 Dec 24 | r01 | ASM Clermont AuvergneASM Clermont | 28 - 0 | BenettonBenetton |
| 07 Dec 24 | r01 | The SharksThe Sharks | 39 - 21 | Exeter ChiefsExeter Chiefs |
| 07 Dec 24 | r01 | Northampton SaintsNorthampton S | 38 - 8 | Castres OlympiqueCastres Olymp |
| 07 Dec 24 | r01 | StormersStormers | 14 - 24 | RC ToulonnaisRC Toulonnais |
| 07 Dec 24 | r01 | MunsterMunster | 33 - 7 | Stade Français ParisStade Françai |
| 07 Dec 24 | r01 | SaracensSaracens | 27 - 5 | Bulls Super RugbyBulls Super R |
| 07 Dec 24 | r01 | GlasgowGlasgow | 38 - 19 | Sale SharksSale Sharks |
| 07 Dec 24 | r01 | Racing Métro 92Racing Métro | 23 - 12 | HarlequinsHarlequins |
| 08 Dec 24 | r01 | Union Bordeaux BèglesUnion Bordeau | 42 - 28 | Leicester TigersLeicester Tig |
| 08 Dec 24 | r01 | Stade ToulousainStade Toulous | 61 - 21 | UlsterUlster |
| 08 Dec 24 | r01 | Bristol RugbyBristol Rugby | 12 - 35 | LeinsterLeinster |
| |
| 13 Dec 24 | r02 | Sale SharksSale Sharks | 29 - 7 | Racing Métro 92Racing Métro |
| 13 Dec 24 | r02 | Castres OlympiqueCastres Olymp | 16 - 14 | MunsterMunster |
| 14 Dec 24 | r02 | Bulls Super RugbyBulls Super R | 21 - 30 | Northampton SaintsNorthampton S |
| 14 Dec 24 | r02 | UlsterUlster | 19 - 40 | Union Bordeaux BèglesUnion Bordeau |
| 14 Dec 24 | r02 | Leicester TigersLeicester Tig | 56 - 17 | The SharksThe Sharks |
| 14 Dec 24 | r02 | LeinsterLeinster | 15 - 7 | ASM Clermont AuvergneASM Clermont |
| 14 Dec 24 | r02 | HarlequinsHarlequins | 53 - 16 | StormersStormers |
| 14 Dec 24 | r02 | Stade RochelaisStade Rochela | 35 - 7 | Bristol RugbyBristol Rugby |
| 15 Dec 24 | r02 | BenettonBenetton | 22 - 21 | Bath RugbyBath Rugby |
| 15 Dec 24 | r02 | Stade Français ParisStade Françai | 17 - 28 | SaracensSaracens |
| 15 Dec 24 | r02 | RC ToulonnaisRC Toulonnais | 30 - 29 | GlasgowGlasgow |
| 15 Dec 24 | r02 | Exeter ChiefsExeter Chiefs | 21 - 64 | Stade ToulousainStade Toulous |
| |
| 10 Jan 25 | r03 | GlasgowGlasgow | 29 - 19 | Racing Métro 92Racing Métro |
| 11 Jan 25 | r03 | StormersStormers | 40 - 0 | Sale SharksSale Sharks |
| 11 Jan 25 | r03 | Exeter ChiefsExeter Chiefs | 17 - 69 | Union Bordeaux BèglesUnion Bordeau |
| 11 Jan 25 | r03 | The SharksThe Sharks | 8 - 20 | Stade ToulousainStade Toulous |
| 11 Jan 25 | r03 | MunsterMunster | 17 - 12 | SaracensSaracens |
| 11 Jan 25 | r03 | Stade Français ParisStade Françai | 45 - 35 | Northampton SaintsNorthampton S |
| 11 Jan 25 | r03 | Castres OlympiqueCastres Olymp | 49 - 10 | Bulls Super RugbyBulls Super R |
| 11 Jan 25 | r03 | Leicester TigersLeicester Tig | 38 - 10 | UlsterUlster |
| 12 Jan 25 | r03 | RC ToulonnaisRC Toulonnais | 33 - 21 | HarlequinsHarlequins |
| 12 Jan 25 | r03 | Bristol RugbyBristol Rugby | 35 - 29 | BenettonBenetton |
| 12 Jan 25 | r03 | Stade RochelaisStade Rochela | 14 - 16 | LeinsterLeinster |
| 12 Jan 25 | r03 | Bath RugbyBath Rugby | 40 - 21 | ASM Clermont AuvergneASM Clermont |
| |
| 17 Jan 25 | r04 | UlsterUlster | 52 - 24 | Exeter ChiefsExeter Chiefs |
| 18 Jan 25 | r04 | Bulls Super RugbyBulls Super R | 48 - 7 | Stade Français ParisStade Françai |
| 18 Jan 25 | r04 | ASM Clermont AuvergneASM Clermont | 33 - 26 | Bristol RugbyBristol Rugby |
| 18 Jan 25 | r04 | Northampton SaintsNorthampton S | 34 - 32 | MunsterMunster |
| 18 Jan 25 | r04 | BenettonBenetton | 32 - 25 | Stade RochelaisStade Rochela |
| 18 Jan 25 | r04 | LeinsterLeinster | 47 - 21 | Bath RugbyBath Rugby |
| 18 Jan 25 | r04 | HarlequinsHarlequins | 24 - 7 | GlasgowGlasgow |
| 18 Jan 25 | r04 | Racing Métro 92Racing Métro | 31 - 22 | StormersStormers |
| 19 Jan 25 | r04 | Union Bordeaux BèglesUnion Bordeau | 66 - 12 | The SharksThe Sharks |
| 19 Jan 25 | r04 | SaracensSaracens | 24 - 32 | Castres OlympiqueCastres Olymp |
| 19 Jan 25 | r04 | Stade ToulousainStade Toulous | 80 - 12 | Leicester TigersLeicester Tig |
| 19 Jan 25 | r04 | Sale SharksSale Sharks | 33 - 7 | RC ToulonnaisRC Toulonnais |
| |
| 04 Apr 25 | r16 | Northampton SaintsNorthampton S | 46 - 24 | ASM Clermont AuvergneASM Clermont |
| 05 Apr 25 | r16 | RC ToulonnaisRC Toulonnais | 72 - 42 | SaracensSaracens |
| 05 Apr 25 | r16 | Castres OlympiqueCastres Olymp | 39 - 37 | BenettonBenetton |
| 05 Apr 25 | r16 | LeinsterLeinster | 62 - 0 | HarlequinsHarlequins |
| 05 Apr 25 | r16 | Stade RochelaisStade Rochela | 24 - 25 | MunsterMunster |
| 05 Apr 25 | r16 | GlasgowGlasgow | 43 - 19 | Leicester TigersLeicester Tig |
| 06 Apr 25 | r16 | Union Bordeaux BèglesUnion Bordeau | 43 - 31 | UlsterUlster |
| 06 Apr 25 | r16 | Stade ToulousainStade Toulous | 38 - 15 | Sale SharksSale Sharks |
| |
| 11 Apr 25 | QF | LeinsterLeinster | 52 - 0 | GlasgowGlasgow |
| 12 Apr 25 | QF | Union Bordeaux BèglesUnion Bordeau | 47 - 29 | MunsterMunster |
| 12 Apr 25 | QF | Northampton SaintsNorthampton S | 51 - 16 | Castres OlympiqueCastres Olymp |
| 13 Apr 25 | QF | RC ToulonnaisRC Toulonnais | 18 - 21 | Stade ToulousainStade Toulous |
| |
| 03 May 25 | SF | LeinsterLeinster | 34 - 37 | Northampton SaintsNorthampton S |
| 04 May 25 | SF | Union Bordeaux BèglesUnion Bordeau | 35 - 18 | Stade ToulousainStade Toulous |
| |
| 24 May 25 | Final | Northampton SaintsNorthampton S | 20 - 28 | Union Bordeaux BèglesUnion Bordeau |
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