| 08 Apr 22 | r16     | ConnachtConnacht | 21 - 26 | LeinsterLeinster |
| 09 Apr 22 | r16 | Sale SharksSale Sharks | 9 - 10 | Bristol RugbyBristol Rugby |
| 09 Apr 22 | r16 | Union Bordeaux BèglesUnion Bordeau | 13 - 31 | Stade RochelaisStade Rochela |
| 09 Apr 22 | r16 | Stade ToulousainStade Toulous | 20 - 26 | UlsterUlster |
| 09 Apr 22 | r16 | Exeter ChiefsExeter Chiefs | 13 - 8 | MunsterMunster |
| 09 Apr 22 | r16 | Stade Français ParisStade Françai | 9 - 22 | Racing Métro 92Racing Métro |
| 10 Apr 22 | r16 | Montpellier Hérault RugbyMontpellier H | 40 - 26 | HarlequinsHarlequins |
| 10 Apr 22 | r16 | ASM Clermont AuvergneASM Clermont | 10 - 29 | Leicester TigersLeicester Tig |
| 15 Apr 22 | r16 | LeinsterLeinster | 56 - 20 | ConnachtConnacht |
| 15 Apr 22 | r16 | Bristol RugbyBristol Rugby | 29 - 35 | Sale SharksSale Sharks |
| 16 Apr 22 | r16 | HarlequinsHarlequins | 33 - 20 | Montpellier Hérault RugbyMontpellier H |
| 16 Apr 22 | r16 | MunsterMunster | 26 - 10 | Exeter ChiefsExeter Chiefs |
| 16 Apr 22 | r16 | Stade RochelaisStade Rochela | 31 - 23 | Union Bordeaux BèglesUnion Bordeau |
| 16 Apr 22 | r16 | Leicester TigersLeicester Tig | 27 - 17 | ASM Clermont AuvergneASM Clermont |
| 16 Apr 22 | r16 | UlsterUlster | 23 - 30 | Stade ToulousainStade Toulous |
| 17 Apr 22 | r16 | Racing Métro 92Racing Métro | 33 - 22 | Stade Français ParisStade Françai |
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