
Team 2021-2022 Scheduals| 10 Dec |
r01 | Northampton SaintsNorthampton S | 14 - 45 | Racing Métro 92Racing Métro |
| 11 Dec |
r01 | Union Bordeaux BèglesUnion Bordeau | 13 - 16 | Leicester TigersLeicester Tig |
| 11 Dec |
r01 | LeinsterLeinster | 45 - 20 | Bath RugbyBath Rugby |
| 11 Dec |
r01 | Bristol RugbyBristol Rugby | 28 - 0 | ScarletsScarlets |
| 11 Dec |
r01 | ASM Clermont AuvergneASM Clermont | 23 - 29 | UlsterUlster |
| 11 Dec |
r01 | Exeter ChiefsExeter Chiefs | 42 - 6 | Montpellier Hérault RugbMontpellier H |
| 12 Dec |
r01 | Cardiff BluesCardiff Blues | 7 - 39 | Stade ToulousainStade Toulous |
| 12 Dec |
r01 | ConnachtConnacht | 36 - 9 | Stade Français ParisStade França |
| 12 Dec |
r01 | OspreysOspreys | 13 - 21 | Sale SharksSale Sharks |
| 12 Dec |
r01 | Stade RochelaisStade Rochela | 20 - 13 | GlasgowGlasgow |
| 12 Dec |
r01 | WaspsWasps | 14 - 35 | MunsterMunster |
| 12 Dec |
r01 | Castres OlympiqueCastres Olymp | 18 - 20 | HarlequinsHarlequins |
| 17 Dec |
r02 | Montpellier Hérault RugbMontpellier H | 28 - 0 | LeinsterLeinster |
| 17 Dec |
r02 | UlsterUlster | 27 - 22 | Northampton SaintsNorthampton S |
| 18 Dec |
r02 | Bath RugbyBath Rugby | 0 - 0 | Stade RochelaisStade Rochela |
| 18 Dec |
r02 | HarlequinsHarlequins | 43 - 17 | Cardiff BluesCardiff Blues |
| 18 Dec |
r02 | Sale SharksSale Sharks | 0 - 0 | ASM Clermont AuvergneASM Clermont |
| 18 Dec |
r02 | GlasgowGlasgow | 22 - 7 | Exeter ChiefsExeter Chiefs |
| 18 Dec |
r02 | Racing Métro 92Racing Métro | 28 - 0 | OspreysOspreys |
| 18 Dec |
r02 | MunsterMunster | 19 - 13 | Castres OlympiqueCastres Olymp |
| 19 Dec |
r02 | Leicester TigersLeicester Tig | 29 - 23 | ConnachtConnacht |
| 19 Dec |
r02 | ScarletsScarlets | 0 - 0 | Union Bordeaux BèglesUnion Bordeau |
| 19 Dec |
r02 | Stade ToulousainStade Toulous | 0 - 0 | WaspsWasps |
| 19 Dec |
r02 | Stade Français ParisStade França | 0 - 0 | Bristol RugbyBristol Rugby |
| 14 Jan |
r03 | Cardiff BluesCardiff Blues | 33 - 36 | HarlequinsHarlequins |
| 14 Jan |
r03 | Castres OlympiqueCastres Olymp | 13 - 16 | MunsterMunster |
| 15 Jan |
r03 | WaspsWasps | 30 - 22 | Stade ToulousainStade Toulous |
| 15 Jan |
r03 | ConnachtConnacht | 28 - 29 | Leicester TigersLeicester Tig |
| 15 Jan |
r03 | OspreysOspreys | 10 - 25 | Racing Métro 92Racing Métro |
| 15 Jan |
r03 | Exeter ChiefsExeter Chiefs | 52 - 17 | GlasgowGlasgow |
| 15 Jan |
r03 | Stade RochelaisStade Rochela | 39 - 21 | Bath RugbyBath Rugby |
| 15 Jan |
r03 | Bristol RugbyBristol Rugby | 28 - 17 | Stade Français ParisStade França |
| 16 Jan |
r03 | LeinsterLeinster | 89 - 7 | Montpellier Hérault RugbMontpellier H |
| 16 Jan |
r03 | Union Bordeaux BèglesUnion Bordeau | 45 - 10 | ScarletsScarlets |
| 16 Jan |
r03 | Northampton SaintsNorthampton S | 20 - 24 | UlsterUlster |
| 16 Jan |
r03 | ASM Clermont AuvergneASM Clermont | 25 - 19 | Sale SharksSale Sharks |
| 21 Jan |
r04 | HarlequinsHarlequins | 36 - 33 | Castres OlympiqueCastres Olymp |
| 22 Jan |
r04 | Bath RugbyBath Rugby | 7 - 64 | LeinsterLeinster |
| 22 Jan |
r04 | Stade ToulousainStade Toulous | 0 - 28 | Cardiff BluesCardiff Blues |
| 22 Jan |
r04 | Leicester TigersLeicester Tig | 28 - 0 | Union Bordeaux BèglesUnion Bordeau |
| 22 Jan |
r04 | ScarletsScarlets | 21 - 52 | Bristol RugbyBristol Rugby |
| 22 Jan |
r04 | UlsterUlster | 34 - 31 | ASM Clermont AuvergneASM Clermont |
| 22 Jan |
r04 | GlasgowGlasgow | 30 - 38 | Stade RochelaisStade Rochela |
| 23 Jan |
r04 | Sale SharksSale Sharks | 49 - 10 | OspreysOspreys |
| 23 Jan |
r04 | Stade Français ParisStade França | 37 - 31 | ConnachtConnacht |
| 23 Jan |
r04 | MunsterMunster | 45 - 7 | WaspsWasps |
| 23 Jan |
r04 | Racing Métro 92Racing Métro | 28 - 0 | Northampton SaintsNorthampton S |
| 23 Jan |
r04 | Montpellier Hérault RugbMontpellier H | 37 - 26 | Exeter ChiefsExeter Chiefs |
| 08 Apr |
r16 | ConnachtConnacht | 21 - 26 | LeinsterLeinster |
| 09 Apr |
r16 | Sale SharksSale Sharks | 9 - 10 | Bristol RugbyBristol Rugby |
| 09 Apr |
r16 | Union Bordeaux BèglesUnion Bordeau | 13 - 31 | Stade RochelaisStade Rochela |
| 09 Apr |
r16 | Stade ToulousainStade Toulous | 20 - 26 | UlsterUlster |
| 09 Apr |
r16 | Exeter ChiefsExeter Chiefs | 13 - 8 | MunsterMunster |
| 09 Apr |
r16 | Stade Français ParisStade França | 9 - 22 | Racing Métro 92Racing Métro |
| 10 Apr |
r16 | Montpellier Hérault RugbMontpellier H | 40 - 26 | HarlequinsHarlequins |
| 10 Apr |
r16 | ASM Clermont AuvergneASM Clermont | 10 - 29 | Leicester TigersLeicester Tig |
| 15 Apr |
r16 | LeinsterLeinster | 56 - 20 | ConnachtConnacht |
| 15 Apr |
r16 | Bristol RugbyBristol Rugby | 29 - 35 | Sale SharksSale Sharks |
| 16 Apr |
r16 | HarlequinsHarlequins | 33 - 20 | Montpellier Hérault RugbMontpellier H |
| 16 Apr |
r16 | MunsterMunster | 26 - 10 | Exeter ChiefsExeter Chiefs |
| 16 Apr |
r16 | Stade RochelaisStade Rochela | 31 - 23 | Union Bordeaux BèglesUnion Bordeau |
| 16 Apr |
r16 | Leicester TigersLeicester Tig | 27 - 17 | ASM Clermont AuvergneASM Clermont |
| 16 Apr |
r16 | UlsterUlster | 23 - 30 | Stade ToulousainStade Toulous |
| 17 Apr |
r16 | Racing Métro 92Racing Métro | 33 - 22 | Stade Français ParisStade França |
| 07 May |
QF | MunsterMunster | 24 - 24 | Stade ToulousainStade Toulous |
| 07 May |
QF | Stade RochelaisStade Rochela | 31 - 19 | Montpellier Hérault RugbMontpellier H |
| 07 May |
QF | Leicester TigersLeicester Tig | 14 - 23 | LeinsterLeinster |
| 08 May |
QF | Racing Métro 92Racing Métro | 41 - 22 | Sale SharksSale Sharks |
| 14 May |
SF | LeinsterLeinster | 40 - 17 | Stade ToulousainStade Toulous |
| 15 May |
SF | Racing Métro 92Racing Métro | 13 - 20 | Stade RochelaisStade Rochela |
| 28 May |
Final | LeinsterLeinster | 21 - 24 | Stade RochelaisStade Rochela |