| 21 Jan 22 | r04        | HarlequinsHarlequins | 36 - 33 | Castres OlympiqueCastres Olymp |
| 22 Jan 22 | r04        | Bath RugbyBath Rugby | 7 - 64 | LeinsterLeinster |
| 22 Jan 22 | r04        | Stade ToulousainStade Toulous | 0 - 28 | Cardiff BluesCardiff Blues |
| 22 Jan 22 | r04        | Leicester TigersLeicester Tig | 28 - 0 | Union Bordeaux BèglesUnion Bordeau |
| 22 Jan 22 | r04        | ScarletsScarlets | 21 - 52 | Bristol RugbyBristol Rugby |
| 22 Jan 22 | r04        | UlsterUlster | 34 - 31 | ASM Clermont AuvergneASM Clermont |
| 22 Jan 22 | r04        | GlasgowGlasgow | 30 - 38 | Stade RochelaisStade Rochela |
| 23 Jan 22 | r04        | Sale SharksSale Sharks | 49 - 10 | OspreysOspreys |
| 23 Jan 22 | r04        | Stade Français ParisStade Françai | 37 - 31 | ConnachtConnacht |
| 23 Jan 22 | r04        | MunsterMunster | 45 - 7 | WaspsWasps |
| 23 Jan 22 | r04        | Racing Métro 92Racing Métro | 28 - 0 | Northampton SaintsNorthampton S |
| 23 Jan 22 | r04        | Montpellier Hérault RugbyMontpellier H | 37 - 26 | Exeter ChiefsExeter Chiefs |