| 10 Dec 21 | r01        | Northampton SaintsNorthampton S | 14 - 45 | Racing Métro 92Racing Métro |
| 11 Dec 21 | r01        | Union Bordeaux BèglesUnion Bordeau | 13 - 16 | Leicester TigersLeicester Tig |
| 11 Dec 21 | r01        | LeinsterLeinster | 45 - 20 | Bath RugbyBath Rugby |
| 11 Dec 21 | r01        | Bristol RugbyBristol Rugby | 28 - 0 | ScarletsScarlets |
| 11 Dec 21 | r01        | ASM Clermont AuvergneASM Clermont | 23 - 29 | UlsterUlster |
| 11 Dec 21 | r01        | Exeter ChiefsExeter Chiefs | 42 - 6 | Montpellier Hérault RugbyMontpellier H |
| 12 Dec 21 | r01        | Cardiff BluesCardiff Blues | 7 - 39 | Stade ToulousainStade Toulous |
| 12 Dec 21 | r01        | ConnachtConnacht | 36 - 9 | Stade Français ParisStade Françai |
| 12 Dec 21 | r01        | OspreysOspreys | 13 - 21 | Sale SharksSale Sharks |
| 12 Dec 21 | r01        | Stade RochelaisStade Rochela | 20 - 13 | GlasgowGlasgow |
| 12 Dec 21 | r01        | WaspsWasps | 14 - 35 | MunsterMunster |
| 12 Dec 21 | r01        | Castres OlympiqueCastres Olymp | 18 - 20 | HarlequinsHarlequins |