| 22 Jan 21 | r04        | LeinsterLeinster | P - P | Montpellier Hérault RugbyMontpellier H |
| 22 Jan 21 | r04        | Sale SharksSale Sharks | P - P | RC ToulonnaisRC Toulonnais |
| 23 Jan 21 | r04        | ScarletsScarlets | P - P | Bath RugbyBath Rugby |
| 23 Jan 21 | r04        | Union Bordeaux BèglesUnion Bordeau | P - P | Northampton SaintsNorthampton S |
| 23 Jan 21 | r04        | ASM Clermont AuvergneASM Clermont | P - P | Bristol RugbyBristol Rugby |
| 23 Jan 21 | r04        | Stade RochelaisStade Rochela | P - P | EdinburghEdinburgh |
| 23 Jan 21 | r04        | HarlequinsHarlequins | P - P | MunsterMunster |
| 23 Jan 21 | r04        | WaspsWasps | P - P | DragonsDragons |
| 23 Jan 21 | r04        | ConnachtConnacht | P - P | Racing Métro 92Racing Métro |
| 24 Jan 21 | r04        | GloucesterGloucester | P - P | Lyon OULyon OU |
| 24 Jan 21 | r04        | RC ToulonnaisRC Toulonnais | P - P | UlsterUlster |
| 24 Jan 21 | r04        | GlasgowGlasgow | P - P | Exeter ChiefsExeter Chiefs |