| 11 Dec 20 | r01        | Northampton SaintsNorthampton S | 12 - 16 | Union Bordeaux BèglesUnion Bordeau |
| 11 Dec 20 | r01        | UlsterUlster | 22 - 29 | Stade ToulousainStade Toulous |
| 12 Dec 20 | r01        | Bristol RugbyBristol Rugby | 38 - 51 | ASM Clermont AuvergneASM Clermont |
| 12 Dec 20 | r01        | Bath RugbyBath Rugby | 19 - 23 | ScarletsScarlets |
| 12 Dec 20 | r01        | RC ToulonnaisRC Toulonnais | 26 - 14 | Sale SharksSale Sharks |
| 12 Dec 20 | r01        | DragonsDragons | 8 - 24 | WaspsWasps |
| 12 Dec 20 | r01        | Montpellier Hérault RugbyMontpellier H | 14 - 35 | LeinsterLeinster |
| 12 Dec 20 | r01        | EdinburghEdinburgh | 8 - 13 | Stade RochelaisStade Rochela |
| 13 Dec 20 | r01        | Lyon OULyon OU | 55 - 10 | GloucesterGloucester |
| 13 Dec 20 | r01        | Exeter ChiefsExeter Chiefs | 42 - 0 | GlasgowGlasgow |
| 13 Dec 20 | r01        | Racing Métro 92Racing Métro | 26 - 22 | ConnachtConnacht |
| 13 Dec 20 | r01        | MunsterMunster | 21 - 7 | HarlequinsHarlequins |
| |
| 18 Dec 20 | r02        | WaspsWasps | 33 - 14 | Montpellier Hérault RugbyMontpellier H |
| 18 Dec 20 | r02        | ScarletsScarlets | 28 - 0 | RC ToulonnaisRC Toulonnais |
| 19 Dec 20 | r02        | LeinsterLeinster | 35 - 19 | Northampton SaintsNorthampton S |
| 19 Dec 20 | r02        | GlasgowGlasgow | 0 - 28 | Lyon OULyon OU |
| 19 Dec 20 | r02        | Stade RochelaisStade Rochela | 28 - 0 | Bath RugbyBath Rugby |
| 19 Dec 20 | r02        | ASM Clermont AuvergneASM Clermont | 31 - 39 | MunsterMunster |
| 19 Dec 20 | r02        | Sale SharksSale Sharks | 15 - 16 | EdinburghEdinburgh |
| 19 Dec 20 | r02        | Union Bordeaux BèglesUnion Bordeau | 47 - 8 | DragonsDragons |
| 19 Dec 20 | r02        | GloucesterGloucester | 38 - 34 | UlsterUlster |
| 20 Dec 20 | r02        | Stade ToulousainStade Toulous | - | Exeter ChiefsExeter Chiefs |
| 20 Dec 20 | r02        | HarlequinsHarlequins | - | Racing Métro 92Racing Métro |
| 20 Dec 20 | r02        | ConnachtConnacht | - | Bristol RugbyBristol Rugby |
| |
| 15 Jan 21 | r03        | Northampton SaintsNorthampton S | P - P | LeinsterLeinster |
| 15 Jan 21 | r03        | RC ToulonnaisRC Toulonnais | P - P | ScarletsScarlets |
| 16 Jan 21 | r03        | UlsterUlster | P - P | GloucesterGloucester |
| 16 Jan 21 | r03        | Lyon OULyon OU | P - P | GlasgowGlasgow |
| 16 Jan 21 | r03        | Exeter ChiefsExeter Chiefs | P - P | Toulouse OlympiqueToulouse Olym |
| 16 Jan 21 | r03        | MunsterMunster | P - P | ASM Clermont AuvergneASM Clermont |
| 16 Jan 21 | r03        | EdinburghEdinburgh | P - P | Sale SharksSale Sharks |
| 16 Jan 21 | r03        | Montpellier Hérault RugbyMontpellier H | P - P | WaspsWasps |
| 17 Jan 21 | r03        | Bath RugbyBath Rugby | P - P | Stade RochelaisStade Rochela |
| 17 Jan 21 | r03        | DragonsDragons | P - P | Union Bordeaux BèglesUnion Bordeau |
| 17 Jan 21 | r03        | Racing Métro 92Racing Métro | P - P | HarlequinsHarlequins |
| 17 Jan 21 | r03        | Bristol RugbyBristol Rugby | P - P | ConnachtConnacht |
| |
| 22 Jan 21 | r04        | LeinsterLeinster | P - P | Montpellier Hérault RugbyMontpellier H |
| 22 Jan 21 | r04        | Sale SharksSale Sharks | P - P | RC ToulonnaisRC Toulonnais |
| 23 Jan 21 | r04        | ScarletsScarlets | P - P | Bath RugbyBath Rugby |
| 23 Jan 21 | r04        | Union Bordeaux BèglesUnion Bordeau | P - P | Northampton SaintsNorthampton S |
| 23 Jan 21 | r04        | ASM Clermont AuvergneASM Clermont | P - P | Bristol RugbyBristol Rugby |
| 23 Jan 21 | r04        | Stade RochelaisStade Rochela | P - P | EdinburghEdinburgh |
| 23 Jan 21 | r04        | HarlequinsHarlequins | P - P | MunsterMunster |
| 23 Jan 21 | r04        | WaspsWasps | P - P | DragonsDragons |
| 23 Jan 21 | r04        | ConnachtConnacht | P - P | Racing Métro 92Racing Métro |
| 24 Jan 21 | r04        | GloucesterGloucester | P - P | Lyon OULyon OU |
| 24 Jan 21 | r04        | RC ToulonnaisRC Toulonnais | P - P | UlsterUlster |
| 24 Jan 21 | r04        | GlasgowGlasgow | P - P | Exeter ChiefsExeter Chiefs |
| |
| 02 Apr 21 | r05        | LeinsterLeinster | - | RC ToulonnaisRC Toulonnais |
| 02 Apr 21 | r05        | GloucesterGloucester | - | Stade RochelaisStade Rochela |
| 03 Apr 21 | r05        | WaspsWasps | - | ASM Clermont AuvergneASM Clermont |
| 03 Apr 21 | r05        | MunsterMunster | - | Stade ToulousainStade Toulous |
| 03 Apr 21 | r05        | Exeter ChiefsExeter Chiefs | - | Lyon OULyon OU |
| 04 Apr 21 | r05        | Racing Métro 92Racing Métro | - | EdinburghEdinburgh |
| 04 Apr 21 | r05        | Union Bordeaux BèglesUnion Bordeau | - | Bristol RugbyBristol Rugby |
| 04 Apr 21 | r05        | ScarletsScarlets | - | Sale SharksSale Sharks |