| 29 Aug 81 | r00  | ArsenalArsenal | 0 - 1 | StokeStoke |
| 29 Aug 81 | r00 | Aston VillaAston Villa | 0 - 1 | Notts CountyNotts County |
| 29 Aug 81 | r00 | CoventryCoventry | 2 - 1 | Manchester UnitedManchester Un |
| 29 Aug 81 | r00 | EvertonEverton | 3 - 1 | BirminghamBirmingham |
| 29 Aug 81 | r00 | IpswichIpswich | 3 - 3 | SunderlandSunderland |
| 29 Aug 81 | r00 | Manchester CityManchester Ci | 2 - 1 | West BromWest Brom |
| 29 Aug 81 | r00 | MiddlesbroughMiddlesbrough | 1 - 3 | TottenhamTottenham |
| 29 Aug 81 | r00 | Nottingham F.Nottingham F. | 2 - 1 | SouthamptonSouthampton |
| 29 Aug 81 | r00 | SwanseaSwansea | 5 - 1 | LeedsLeeds |
| 29 Aug 81 | r00 | West HamWest Ham | 1 - 1 | BrightonBrighton |
| 29 Aug 81 | r00 | WolvesWolves | 1 - 0 | LiverpoolLiverpool |
| 31 Aug 81 | r00 | Manchester UnitedManchester Un | 0 - 0 | Nottingham F.Nottingham F. |
| 01 Sep 81 | r00 | BirminghamBirmingham | 1 - 1 | IpswichIpswich |
| 01 Sep 81 | r00 | BrightonBrighton | 1 - 2 | SwanseaSwansea |
| 01 Sep 81 | r00 | LiverpoolLiverpool | 1 - 1 | MiddlesbroughMiddlesbrough |
| 01 Sep 81 | r00 | Notts CountyNotts County | 1 - 1 | Manchester CityManchester Ci |
| 01 Sep 81 | r00 | SouthamptonSouthampton | 4 - 1 | WolvesWolves |
| 02 Sep 81 | r00 | LeedsLeeds | 1 - 1 | EvertonEverton |
| 02 Sep 81 | r00 | StokeStoke | 4 - 0 | CoventryCoventry |
| 02 Sep 81 | r00 | SunderlandSunderland | 2 - 1 | Aston VillaAston Villa |
| 02 Sep 81 | r00 | TottenhamTottenham | 0 - 4 | West HamWest Ham |
| 02 Sep 81 | r00 | West BromWest Brom | 0 - 2 | ArsenalArsenal |
| 05 Sep 81 | r00 | BirminghamBirmingham | 4 - 3 | Nottingham F.Nottingham F. |
| 05 Sep 81 | r00 | BrightonBrighton | 2 - 0 | MiddlesbroughMiddlesbrough |
| 05 Sep 81 | r00 | LeedsLeeds | 3 - 0 | WolvesWolves |
| 05 Sep 81 | r00 | LiverpoolLiverpool | 2 - 0 | ArsenalArsenal |
| 05 Sep 81 | r00 | Manchester UnitedManchester Un | 1 - 2 | IpswichIpswich |
| 05 Sep 81 | r00 | Notts CountyNotts County | 2 - 1 | CoventryCoventry |
| 05 Sep 81 | r00 | SouthamptonSouthampton | 1 - 0 | EvertonEverton |
| 05 Sep 81 | r00 | StokeStoke | 1 - 3 | Manchester CityManchester Ci |
| 05 Sep 81 | r00 | SunderlandSunderland | 0 - 2 | West HamWest Ham |
| 05 Sep 81 | r00 | TottenhamTottenham | 1 - 3 | Aston VillaAston Villa |
| 05 Sep 81 | r00 | West BromWest Brom | 4 - 1 | SwanseaSwansea |
| 12 Sep 81 | r00 | ArsenalArsenal | 1 - 1 | SunderlandSunderland |
| 12 Sep 81 | r00 | Aston VillaAston Villa | 1 - 1 | Manchester UnitedManchester Un |
| 12 Sep 81 | r00 | CoventryCoventry | 4 - 0 | LeedsLeeds |
| 12 Sep 81 | r00 | EvertonEverton | 1 - 1 | BrightonBrighton |
| 12 Sep 81 | r00 | IpswichIpswich | 2 - 0 | LiverpoolLiverpool |
| 12 Sep 81 | r00 | Manchester CityManchester Ci | 1 - 1 | SouthamptonSouthampton |
| 12 Sep 81 | r00 | MiddlesbroughMiddlesbrough | 2 - 1 | BirminghamBirmingham |
| 12 Sep 81 | r00 | Nottingham F.Nottingham F. | 0 - 0 | West BromWest Brom |
| 12 Sep 81 | r00 | SwanseaSwansea | 3 - 2 | Notts CountyNotts County |
| 12 Sep 81 | r00 | West HamWest Ham | 3 - 2 | StokeStoke |
| 12 Sep 81 | r00 | WolvesWolves | 0 - 1 | TottenhamTottenham |
| 19 Sep 81 | r00 | BirminghamBirmingham | 3 - 0 | Manchester CityManchester Ci |
| 19 Sep 81 | r00 | BrightonBrighton | 2 - 2 | CoventryCoventry |
| 19 Sep 81 | r00 | LeedsLeeds | 0 - 0 | ArsenalArsenal |
| 19 Sep 81 | r00 | LiverpoolLiverpool | 0 - 0 | Aston VillaAston Villa |
| 19 Sep 81 | r00 | Manchester UnitedManchester Un | 1 - 0 | SwanseaSwansea |
| 19 Sep 81 | r00 | Notts CountyNotts County | 1 - 4 | IpswichIpswich |
| 19 Sep 81 | r00 | SouthamptonSouthampton | 2 - 0 | MiddlesbroughMiddlesbrough |
| 19 Sep 81 | r00 | StokeStoke | 1 - 2 | Nottingham F.Nottingham F. |
| 19 Sep 81 | r00 | SunderlandSunderland | 0 - 0 | WolvesWolves |
| 19 Sep 81 | r00 | TottenhamTottenham | 3 - 0 | EvertonEverton |
| 19 Sep 81 | r00 | West BromWest Brom | 0 - 0 | West HamWest Ham |
| 22 Sep 81 | r00 | ArsenalArsenal | 1 - 0 | BirminghamBirmingham |
| 22 Sep 81 | r00 | CoventryCoventry | 1 - 2 | LiverpoolLiverpool |
| 22 Sep 81 | r00 | EvertonEverton | 3 - 1 | Notts CountyNotts County |
| 22 Sep 81 | r00 | IpswichIpswich | 1 - 0 | West BromWest Brom |
| 22 Sep 81 | r00 | MiddlesbroughMiddlesbrough | 0 - 2 | Manchester UnitedManchester Un |
| 22 Sep 81 | r00 | SwanseaSwansea | 2 - 1 | TottenhamTottenham |
| 22 Sep 81 | r00 | West HamWest Ham | 4 - 2 | SouthamptonSouthampton |
| 22 Sep 81 | r00 | WolvesWolves | 0 - 1 | BrightonBrighton |
| 23 Sep 81 | r00 | Aston VillaAston Villa | 2 - 2 | StokeStoke |
| 23 Sep 81 | r00 | Manchester CityManchester Ci | 4 - 0 | LeedsLeeds |
| 23 Sep 81 | r00 | Nottingham F.Nottingham F. | 2 - 0 | SunderlandSunderland |
| 26 Sep 81 | r00 | ArsenalArsenal | 0 - 0 | Manchester UnitedManchester Un |
| 26 Sep 81 | r00 | Aston VillaAston Villa | 0 - 0 | BirminghamBirmingham |
| 26 Sep 81 | r00 | CoventryCoventry | 4 - 2 | SouthamptonSouthampton |
| 26 Sep 81 | r00 | EvertonEverton | 1 - 0 | West BromWest Brom |
| 26 Sep 81 | r00 | IpswichIpswich | 2 - 1 | LeedsLeeds |
| 26 Sep 81 | r00 | Manchester CityManchester Ci | 0 - 1 | TottenhamTottenham |
| 26 Sep 81 | r00 | MiddlesbroughMiddlesbrough | 3 - 2 | StokeStoke |
| 26 Sep 81 | r00 | Nottingham F.Nottingham F. | 2 - 1 | BrightonBrighton |
| 26 Sep 81 | r00 | SwanseaSwansea | 2 - 0 | SunderlandSunderland |
| 26 Sep 81 | r00 | West HamWest Ham | 1 - 1 | LiverpoolLiverpool |
| 26 Sep 81 | r00 | WolvesWolves | 3 - 2 | Notts CountyNotts County |
| 30 Sep 81 | r00 | Manchester UnitedManchester Un | 1 - 0 | LeedsLeeds |
| 03 Oct 81 | r00 | BirminghamBirmingham | 2 - 2 | West HamWest Ham |
| 03 Oct 81 | r00 | BrightonBrighton | 4 - 1 | Manchester CityManchester Ci |
| 03 Oct 81 | r00 | LeedsLeeds | 1 - 1 | Aston VillaAston Villa |
| 03 Oct 81 | r00 | LiverpoolLiverpool | 2 - 2 | SwanseaSwansea |
| 03 Oct 81 | r00 | Manchester UnitedManchester Un | 5 - 0 | WolvesWolves |
| 03 Oct 81 | r00 | Notts CountyNotts County | 2 - 1 | ArsenalArsenal |
| 03 Oct 81 | r00 | SouthamptonSouthampton | 4 - 3 | IpswichIpswich |
| 03 Oct 81 | r00 | StokeStoke | 3 - 1 | EvertonEverton |
| 03 Oct 81 | r00 | SunderlandSunderland | 0 - 0 | CoventryCoventry |
| 03 Oct 81 | r00 | TottenhamTottenham | 3 - 0 | Nottingham F.Nottingham F. |
| 03 Oct 81 | r00 | West BromWest Brom | 2 - 0 | MiddlesbroughMiddlesbrough |
| 10 Oct 81 | r00 | BirminghamBirmingham | 4 - 0 | SouthamptonSouthampton |
| 10 Oct 81 | r00 | CoventryCoventry | 1 - 1 | Aston VillaAston Villa |
| 10 Oct 81 | r00 | IpswichIpswich | 1 - 0 | WolvesWolves |
| 10 Oct 81 | r00 | LiverpoolLiverpool | 3 - 0 | LeedsLeeds |
| 10 Oct 81 | r00 | Manchester CityManchester Ci | 0 - 0 | Manchester UnitedManchester Un |
| 10 Oct 81 | r00 | MiddlesbroughMiddlesbrough | 1 - 1 | Nottingham F.Nottingham F. |
| 10 Oct 81 | r00 | Notts CountyNotts County | 2 - 0 | SunderlandSunderland |
| 10 Oct 81 | r00 | SwanseaSwansea | 2 - 0 | ArsenalArsenal |
| 10 Oct 81 | r00 | TottenhamTottenham | 2 - 0 | StokeStoke |
| 10 Oct 81 | r00 | West BromWest Brom | 0 - 0 | BrightonBrighton |
| 10 Oct 81 | r00 | West HamWest Ham | 1 - 1 | EvertonEverton |
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