| 26 Aug 22 | r00  | Aston VillaAston Villa | 2 - 0 | BlackburnBlackburn |
| 26 Aug 22 | r00 | BurnleyBurnley | 3 - 0 | West BromWest Brom |
| 26 Aug 22 | r00 | ChelseaChelsea | 1 - 1 | BirminghamBirmingham |
| 26 Aug 22 | r00 | LiverpoolLiverpool | 5 - 2 | ArsenalArsenal |
| 26 Aug 22 | r00 | MiddlesbroughMiddlesbrough | 2 - 2 | Huddersfield TownHuddersfield |
| 26 Aug 22 | r00 | NewcastleNewcastle | 2 - 0 | EvertonEverton |
| 26 Aug 22 | r00 | Nottingham F.Nottingham F. | 1 - 0 | SunderlandSunderland |
| 26 Aug 22 | r00 | OldhamOldham | 4 - 1 | StokeStoke |
| 26 Aug 22 | r00 | PrestonPreston | 3 - 1 | BoltonBolton |
| 26 Aug 22 | r00 | Sheffield UnitedSheffield Uni | 2 - 0 | Manchester CityManchester Ci |
| 26 Aug 22 | r00 | TottenhamTottenham | 1 - 1 | CardiffCardiff |
| 28 Aug 22 | r00 | ArsenalArsenal | 1 - 1 | BurnleyBurnley |
| 28 Aug 22 | r00 | BirminghamBirmingham | 0 - 2 | NewcastleNewcastle |
| 28 Aug 22 | r00 | CardiffCardiff | 3 - 0 | Aston VillaAston Villa |
| 28 Aug 22 | r00 | Huddersfield TownHuddersfield | 2 - 1 | Nottingham F.Nottingham F. |
| 28 Aug 22 | r00 | Manchester CityManchester Ci | 2 - 1 | MiddlesbroughMiddlesbrough |
| 28 Aug 22 | r00 | StokeStoke | 1 - 2 | ChelseaChelsea |
| 28 Aug 22 | r00 | West BromWest Brom | 2 - 2 | PrestonPreston |
| 30 Aug 22 | r00 | SunderlandSunderland | 1 - 0 | LiverpoolLiverpool |
| 02 Sep 22 | r00 | ArsenalArsenal | 1 - 0 | LiverpoolLiverpool |
| 02 Sep 22 | r00 | BirminghamBirmingham | 0 - 1 | ChelseaChelsea |
| 02 Sep 22 | r00 | BlackburnBlackburn | 4 - 2 | Aston VillaAston Villa |
| 02 Sep 22 | r00 | BoltonBolton | 1 - 1 | PrestonPreston |
| 02 Sep 22 | r00 | CardiffCardiff | 2 - 3 | TottenhamTottenham |
| 02 Sep 22 | r00 | EvertonEverton | 3 - 2 | NewcastleNewcastle |
| 02 Sep 22 | r00 | Huddersfield TownHuddersfield | 0 - 2 | MiddlesbroughMiddlesbrough |
| 02 Sep 22 | r00 | Manchester CityManchester Ci | 3 - 3 | Sheffield UnitedSheffield Uni |
| 02 Sep 22 | r00 | StokeStoke | 2 - 2 | OldhamOldham |
| 02 Sep 22 | r00 | SunderlandSunderland | 0 - 0 | Nottingham F.Nottingham F. |
| 02 Sep 22 | r00 | West BromWest Brom | 2 - 1 | BurnleyBurnley |
| 04 Sep 22 | r00 | Aston VillaAston Villa | 1 - 3 | CardiffCardiff |
| 04 Sep 22 | r00 | BoltonBolton | 3 - 1 | OldhamOldham |
| 04 Sep 22 | r00 | BurnleyBurnley | 4 - 1 | ArsenalArsenal |
| 04 Sep 22 | r00 | ChelseaChelsea | 3 - 2 | StokeStoke |
| 04 Sep 22 | r00 | MiddlesbroughMiddlesbrough | 5 - 0 | Manchester CityManchester Ci |
| 04 Sep 22 | r00 | Nottingham F.Nottingham F. | 0 - 1 | Huddersfield TownHuddersfield |
| 04 Sep 22 | r00 | PrestonPreston | 0 - 0 | West BromWest Brom |
| 04 Sep 22 | r00 | Sheffield UnitedSheffield Uni | 1 - 1 | BlackburnBlackburn |
| 04 Sep 22 | r00 | TottenhamTottenham | 2 - 0 | EvertonEverton |
| 06 Sep 22 | r00 | LiverpoolLiverpool | 5 - 1 | SunderlandSunderland |
| 06 Sep 22 | r00 | NewcastleNewcastle | 0 - 0 | BirminghamBirmingham |
| 09 Sep 22 | r00 | Aston VillaAston Villa | 2 - 0 | West BromWest Brom |
| 09 Sep 22 | r00 | BoltonBolton | 1 - 1 | SunderlandSunderland |
| 09 Sep 22 | r00 | CardiffCardiff | 4 - 1 | ArsenalArsenal |
| 09 Sep 22 | r00 | ChelseaChelsea | 1 - 1 | MiddlesbroughMiddlesbrough |
| 09 Sep 22 | r00 | EvertonEverton | 2 - 0 | BlackburnBlackburn |
| 09 Sep 22 | r00 | Manchester CityManchester Ci | 0 - 1 | BirminghamBirmingham |
| 09 Sep 22 | r00 | NewcastleNewcastle | 3 - 0 | Sheffield UnitedSheffield Uni |
| 09 Sep 22 | r00 | OldhamOldham | 2 - 0 | Nottingham F.Nottingham F. |
| 09 Sep 22 | r00 | PrestonPreston | 1 - 3 | LiverpoolLiverpool |
| 09 Sep 22 | r00 | StokeStoke | 2 - 2 | Huddersfield TownHuddersfield |
| 09 Sep 22 | r00 | TottenhamTottenham | 1 - 3 | BurnleyBurnley |
| 11 Sep 22 | r00 | OldhamOldham | 3 - 1 | BoltonBolton |
| 13 Sep 22 | r00 | BirminghamBirmingham | 2 - 0 | StokeStoke |
| 16 Sep 22 | r00 | ArsenalArsenal | 2 - 1 | CardiffCardiff |
| 16 Sep 22 | r00 | BirminghamBirmingham | 0 - 1 | Manchester CityManchester Ci |
| 16 Sep 22 | r00 | BlackburnBlackburn | 5 - 1 | EvertonEverton |
| 16 Sep 22 | r00 | BurnleyBurnley | 0 - 1 | TottenhamTottenham |
| 16 Sep 22 | r00 | Huddersfield TownHuddersfield | 1 - 0 | StokeStoke |
| 16 Sep 22 | r00 | LiverpoolLiverpool | 5 - 2 | PrestonPreston |
| 16 Sep 22 | r00 | MiddlesbroughMiddlesbrough | 2 - 1 | ChelseaChelsea |
| 16 Sep 22 | r00 | Nottingham F.Nottingham F. | 1 - 0 | OldhamOldham |
| 16 Sep 22 | r00 | Sheffield UnitedSheffield Uni | 2 - 0 | NewcastleNewcastle |
| 16 Sep 22 | r00 | SunderlandSunderland | 5 - 1 | BoltonBolton |
| 16 Sep 22 | r00 | West BromWest Brom | 3 - 0 | Aston VillaAston Villa |
| 18 Sep 22 | r00 | BlackburnBlackburn | 1 - 0 | Sheffield UnitedSheffield Uni |
| 23 Sep 22 | r00 | Aston VillaAston Villa | 2 - 2 | MiddlesbroughMiddlesbrough |
| 23 Sep 22 | r00 | BlackburnBlackburn | 0 - 0 | SunderlandSunderland |
| 23 Sep 22 | r00 | BoltonBolton | 3 - 0 | BirminghamBirmingham |
| 23 Sep 22 | r00 | CardiffCardiff | 0 - 2 | EvertonEverton |
| 23 Sep 22 | r00 | ChelseaChelsea | 4 - 0 | OldhamOldham |
| 23 Sep 22 | r00 | LiverpoolLiverpool | 3 - 0 | BurnleyBurnley |
| 23 Sep 22 | r00 | Manchester CityManchester Ci | 3 - 1 | Huddersfield TownHuddersfield |
| 23 Sep 22 | r00 | NewcastleNewcastle | 3 - 1 | PrestonPreston |
| 23 Sep 22 | r00 | Nottingham F.Nottingham F. | 1 - 0 | Sheffield UnitedSheffield Uni |
| 23 Sep 22 | r00 | StokeStoke | 0 - 2 | West BromWest Brom |
| 23 Sep 22 | r00 | TottenhamTottenham | 1 - 2 | ArsenalArsenal |
| 30 Sep 22 | r00 | ArsenalArsenal | 0 - 2 | TottenhamTottenham |
| 30 Sep 22 | r00 | BirminghamBirmingham | 2 - 0 | BoltonBolton |
| 30 Sep 22 | r00 | BurnleyBurnley | 2 - 0 | LiverpoolLiverpool |
| 30 Sep 22 | r00 | EvertonEverton | 3 - 1 | CardiffCardiff |
| 30 Sep 22 | r00 | Huddersfield TownHuddersfield | 0 - 0 | Manchester CityManchester Ci |
| 30 Sep 22 | r00 | MiddlesbroughMiddlesbrough | 2 - 2 | Aston VillaAston Villa |
| 30 Sep 22 | r00 | OldhamOldham | 2 - 0 | ChelseaChelsea |
| 30 Sep 22 | r00 | PrestonPreston | 1 - 0 | NewcastleNewcastle |
| 30 Sep 22 | r00 | Sheffield UnitedSheffield Uni | 0 - 0 | Nottingham F.Nottingham F. |
| 30 Sep 22 | r00 | SunderlandSunderland | 4 - 3 | BlackburnBlackburn |
| 30 Sep 22 | r00 | West BromWest Brom | 0 - 1 | StokeStoke |
| 02 Oct 22 | r00 | Sheffield UnitedSheffield Uni | 2 - 1 | ArsenalArsenal |
| 05 Oct 22 | r00 | Nottingham F.Nottingham F. | 1 - 1 | BoltonBolton |
| 07 Oct 22 | r00 | ArsenalArsenal | 3 - 1 | West BromWest Brom |
| 07 Oct 22 | r00 | Aston VillaAston Villa | 2 - 0 | TottenhamTottenham |
| 07 Oct 22 | r00 | BlackburnBlackburn | 1 - 1 | BirminghamBirmingham |
| 07 Oct 22 | r00 | BoltonBolton | 1 - 0 | Huddersfield TownHuddersfield |
| 07 Oct 22 | r00 | CardiffCardiff | 2 - 4 | SunderlandSunderland |
| 07 Oct 22 | r00 | ChelseaChelsea | 0 - 0 | Sheffield UnitedSheffield Uni |
| 07 Oct 22 | r00 | LiverpoolLiverpool | 5 - 1 | EvertonEverton |
| 07 Oct 22 | r00 | NewcastleNewcastle | 0 - 2 | BurnleyBurnley |
| 07 Oct 22 | r00 | Nottingham F.Nottingham F. | 3 - 0 | PrestonPreston |
| 07 Oct 22 | r00 | OldhamOldham | 0 - 0 | MiddlesbroughMiddlesbrough |
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