| 27 Aug 21 | r00  | ArsenalArsenal | 1 - 2 | Sheffield UnitedSheffield Uni |
| 27 Aug 21 | r00 | BirminghamBirmingham | 2 - 3 | BurnleyBurnley |
| 27 Aug 21 | r00 | BlackburnBlackburn | 1 - 1 | ChelseaChelsea |
| 27 Aug 21 | r00 | BoltonBolton | 2 - 2 | PrestonPreston |
| 27 Aug 21 | r00 | CardiffCardiff | 0 - 1 | TottenhamTottenham |
| 27 Aug 21 | r00 | EvertonEverton | 5 - 0 | Manchester UnitedManchester Un |
| 27 Aug 21 | r00 | Huddersfield TownHuddersfield | 1 - 2 | NewcastleNewcastle |
| 27 Aug 21 | r00 | Manchester CityManchester Ci | 2 - 1 | Aston VillaAston Villa |
| 27 Aug 21 | r00 | OldhamOldham | 0 - 0 | BradfordBradford |
| 27 Aug 21 | r00 | SunderlandSunderland | 3 - 0 | LiverpoolLiverpool |
| 27 Aug 21 | r00 | West BromWest Brom | 0 - 0 | MiddlesbroughMiddlesbrough |
| 29 Aug 21 | r00 | Aston VillaAston Villa | 2 - 1 | CardiffCardiff |
| 29 Aug 21 | r00 | BradfordBradford | 1 - 1 | BlackburnBlackburn |
| 29 Aug 21 | r00 | ChelseaChelsea | 1 - 2 | BirminghamBirmingham |
| 29 Aug 21 | r00 | Manchester UnitedManchester Un | 2 - 3 | West BromWest Brom |
| 29 Aug 21 | r00 | MiddlesbroughMiddlesbrough | 1 - 1 | OldhamOldham |
| 29 Aug 21 | r00 | PrestonPreston | 3 - 2 | ArsenalArsenal |
| 29 Aug 21 | r00 | Sheffield UnitedSheffield Uni | 1 - 1 | Huddersfield TownHuddersfield |
| 29 Aug 21 | r00 | TottenhamTottenham | 1 - 2 | BoltonBolton |
| 31 Aug 21 | r00 | LiverpoolLiverpool | 3 - 2 | Manchester CityManchester Ci |
| 31 Aug 21 | r00 | NewcastleNewcastle | 3 - 0 | EvertonEverton |
| 31 Aug 21 | r00 | SunderlandSunderland | 3 - 2 | BurnleyBurnley |
| 03 Sep 21 | r00 | Aston VillaAston Villa | 4 - 0 | Manchester CityManchester Ci |
| 03 Sep 21 | r00 | BradfordBradford | 3 - 0 | OldhamOldham |
| 03 Sep 21 | r00 | BurnleyBurnley | 3 - 1 | BirminghamBirmingham |
| 03 Sep 21 | r00 | ChelseaChelsea | 1 - 0 | BlackburnBlackburn |
| 03 Sep 21 | r00 | LiverpoolLiverpool | 2 - 1 | SunderlandSunderland |
| 03 Sep 21 | r00 | Manchester UnitedManchester Un | 2 - 1 | EvertonEverton |
| 03 Sep 21 | r00 | MiddlesbroughMiddlesbrough | 3 - 2 | West BromWest Brom |
| 03 Sep 21 | r00 | NewcastleNewcastle | 1 - 2 | Huddersfield TownHuddersfield |
| 03 Sep 21 | r00 | PrestonPreston | 3 - 1 | BoltonBolton |
| 03 Sep 21 | r00 | Sheffield UnitedSheffield Uni | 4 - 1 | ArsenalArsenal |
| 03 Sep 21 | r00 | TottenhamTottenham | 4 - 1 | CardiffCardiff |
| 05 Sep 21 | r00 | ArsenalArsenal | 1 - 0 | PrestonPreston |
| 05 Sep 21 | r00 | BirminghamBirmingham | 5 - 1 | ChelseaChelsea |
| 05 Sep 21 | r00 | BoltonBolton | 1 - 0 | TottenhamTottenham |
| 05 Sep 21 | r00 | BurnleyBurnley | 2 - 0 | SunderlandSunderland |
| 05 Sep 21 | r00 | CardiffCardiff | 0 - 4 | Aston VillaAston Villa |
| 05 Sep 21 | r00 | OldhamOldham | 0 - 1 | MiddlesbroughMiddlesbrough |
| 06 Sep 21 | r00 | Huddersfield TownHuddersfield | 1 - 1 | Sheffield UnitedSheffield Uni |
| 07 Sep 21 | r00 | EvertonEverton | 2 - 3 | NewcastleNewcastle |
| 07 Sep 21 | r00 | Manchester CityManchester Ci | 1 - 1 | LiverpoolLiverpool |
| 07 Sep 21 | r00 | West BromWest Brom | 0 - 0 | Manchester UnitedManchester Un |
| 10 Sep 21 | r00 | BoltonBolton | 3 - 3 | BradfordBradford |
| 10 Sep 21 | r00 | BurnleyBurnley | 2 - 0 | NewcastleNewcastle |
| 10 Sep 21 | r00 | CardiffCardiff | 0 - 1 | OldhamOldham |
| 10 Sep 21 | r00 | ChelseaChelsea | 0 - 0 | Manchester UnitedManchester Un |
| 10 Sep 21 | r00 | EvertonEverton | 2 - 1 | BirminghamBirmingham |
| 10 Sep 21 | r00 | Manchester CityManchester Ci | 2 - 0 | ArsenalArsenal |
| 10 Sep 21 | r00 | PrestonPreston | 1 - 0 | Aston VillaAston Villa |
| 10 Sep 21 | r00 | Sheffield UnitedSheffield Uni | 0 - 1 | LiverpoolLiverpool |
| 10 Sep 21 | r00 | SunderlandSunderland | 2 - 2 | Huddersfield TownHuddersfield |
| 10 Sep 21 | r00 | TottenhamTottenham | 2 - 4 | MiddlesbroughMiddlesbrough |
| 10 Sep 21 | r00 | West BromWest Brom | 0 - 2 | BlackburnBlackburn |
| 12 Sep 21 | r00 | Aston VillaAston Villa | 1 - 1 | BlackburnBlackburn |
| 17 Sep 21 | r00 | ArsenalArsenal | 0 - 1 | Manchester CityManchester Ci |
| 17 Sep 21 | r00 | Aston VillaAston Villa | 2 - 0 | PrestonPreston |
| 17 Sep 21 | r00 | BirminghamBirmingham | 1 - 1 | EvertonEverton |
| 17 Sep 21 | r00 | BlackburnBlackburn | 2 - 3 | West BromWest Brom |
| 17 Sep 21 | r00 | BradfordBradford | 4 - 3 | BoltonBolton |
| 17 Sep 21 | r00 | Huddersfield TownHuddersfield | 1 - 2 | SunderlandSunderland |
| 17 Sep 21 | r00 | LiverpoolLiverpool | 1 - 1 | Sheffield UnitedSheffield Uni |
| 17 Sep 21 | r00 | Manchester UnitedManchester Un | 0 - 0 | ChelseaChelsea |
| 17 Sep 21 | r00 | MiddlesbroughMiddlesbrough | 0 - 0 | TottenhamTottenham |
| 17 Sep 21 | r00 | NewcastleNewcastle | 2 - 1 | BurnleyBurnley |
| 17 Sep 21 | r00 | OldhamOldham | 2 - 1 | CardiffCardiff |
| 19 Sep 21 | r00 | BlackburnBlackburn | 3 - 1 | BradfordBradford |
| 24 Sep 21 | r00 | BoltonBolton | 3 - 1 | Huddersfield TownHuddersfield |
| 24 Sep 21 | r00 | BurnleyBurnley | 4 - 0 | BradfordBradford |
| 24 Sep 21 | r00 | CardiffCardiff | 3 - 1 | MiddlesbroughMiddlesbrough |
| 24 Sep 21 | r00 | ChelseaChelsea | 0 - 1 | LiverpoolLiverpool |
| 24 Sep 21 | r00 | EvertonEverton | 1 - 1 | ArsenalArsenal |
| 24 Sep 21 | r00 | Manchester CityManchester Ci | 1 - 1 | BlackburnBlackburn |
| 24 Sep 21 | r00 | PrestonPreston | 3 - 2 | Manchester UnitedManchester Un |
| 24 Sep 21 | r00 | Sheffield UnitedSheffield Uni | 1 - 1 | NewcastleNewcastle |
| 24 Sep 21 | r00 | SunderlandSunderland | 2 - 1 | BirminghamBirmingham |
| 24 Sep 21 | r00 | TottenhamTottenham | 3 - 1 | Aston VillaAston Villa |
| 24 Sep 21 | r00 | West BromWest Brom | 0 - 1 | OldhamOldham |
| 01 Oct 21 | r00 | ArsenalArsenal | 1 - 0 | EvertonEverton |
| 01 Oct 21 | r00 | Aston VillaAston Villa | 2 - 1 | TottenhamTottenham |
| 01 Oct 21 | r00 | BirminghamBirmingham | 1 - 0 | SunderlandSunderland |
| 01 Oct 21 | r00 | BlackburnBlackburn | 3 - 1 | Manchester CityManchester Ci |
| 01 Oct 21 | r00 | BradfordBradford | 0 - 4 | BurnleyBurnley |
| 01 Oct 21 | r00 | Huddersfield TownHuddersfield | 3 - 0 | BoltonBolton |
| 01 Oct 21 | r00 | LiverpoolLiverpool | 1 - 1 | ChelseaChelsea |
| 01 Oct 21 | r00 | Manchester UnitedManchester Un | 1 - 1 | PrestonPreston |
| 01 Oct 21 | r00 | MiddlesbroughMiddlesbrough | 0 - 0 | CardiffCardiff |
| 01 Oct 21 | r00 | NewcastleNewcastle | 2 - 1 | Sheffield UnitedSheffield Uni |
| 01 Oct 21 | r00 | OldhamOldham | 1 - 0 | West BromWest Brom |
| 08 Oct 21 | r00 | BirminghamBirmingham | 0 - 2 | Huddersfield TownHuddersfield |
| 08 Oct 21 | r00 | BradfordBradford | 0 - 2 | MiddlesbroughMiddlesbrough |
| 08 Oct 21 | r00 | BurnleyBurnley | 2 - 1 | Sheffield UnitedSheffield Uni |
| 08 Oct 21 | r00 | CardiffCardiff | 1 - 2 | BoltonBolton |
| 08 Oct 21 | r00 | ChelseaChelsea | 1 - 1 | NewcastleNewcastle |
| 08 Oct 21 | r00 | EvertonEverton | 2 - 0 | BlackburnBlackburn |
| 08 Oct 21 | r00 | Manchester CityManchester Ci | 2 - 1 | OldhamOldham |
| 08 Oct 21 | r00 | PrestonPreston | 1 - 1 | LiverpoolLiverpool |
| 08 Oct 21 | r00 | SunderlandSunderland | 1 - 0 | ArsenalArsenal |
| 08 Oct 21 | r00 | TottenhamTottenham | 2 - 2 | Manchester UnitedManchester Un |
| 08 Oct 21 | r00 | West BromWest Brom | 0 - 1 | Aston VillaAston Villa |
| 15 Oct 21 | r00 | ArsenalArsenal | 1 - 2 | SunderlandSunderland |
| 15 Oct 21 | r00 | Aston VillaAston Villa | 0 - 1 | West BromWest Brom |
| 15 Oct 21 | r00 | BlackburnBlackburn | 2 - 2 | EvertonEverton |
| 15 Oct 21 | r00 | BoltonBolton | 1 - 2 | CardiffCardiff |
| 15 Oct 21 | r00 | Huddersfield TownHuddersfield | 1 - 0 | BirminghamBirmingham |
| 15 Oct 21 | r00 | LiverpoolLiverpool | 4 - 0 | PrestonPreston |
| 15 Oct 21 | r00 | Manchester UnitedManchester Un | 2 - 1 | TottenhamTottenham |
| 15 Oct 21 | r00 | MiddlesbroughMiddlesbrough | 1 - 2 | BradfordBradford |
| 15 Oct 21 | r00 | NewcastleNewcastle | 1 - 0 | ChelseaChelsea |
| 15 Oct 21 | r00 | OldhamOldham | 0 - 1 | Manchester CityManchester Ci |
| 15 Oct 21 | r00 | Sheffield UnitedSheffield Uni | 0 - 1 | BurnleyBurnley |
| 22 Oct 21 | r00 | BirminghamBirmingham | 1 - 1 | BoltonBolton |
| 22 Oct 21 | r00 | BradfordBradford | 1 - 1 | Sheffield UnitedSheffield Uni |
| 22 Oct 21 | r00 | BurnleyBurnley | 5 - 0 | ChelseaChelsea |
| 22 Oct 21 | r00 | EvertonEverton | 2 - 2 | OldhamOldham |
| 22 Oct 21 | r00 | Huddersfield TownHuddersfield | 2 - 0 | ArsenalArsenal |
| 22 Oct 21 | r00 | Manchester CityManchester Ci | 4 - 1 | Manchester UnitedManchester Un |
| 22 Oct 21 | r00 | MiddlesbroughMiddlesbrough | 5 - 0 | Aston VillaAston Villa |
| 22 Oct 21 | r00 | PrestonPreston | 2 - 0 | NewcastleNewcastle |
| 22 Oct 21 | r00 | SunderlandSunderland | 3 - 1 | BlackburnBlackburn |
| 22 Oct 21 | r00 | TottenhamTottenham | 0 - 1 | LiverpoolLiverpool |
| 22 Oct 21 | r00 | West BromWest Brom | 2 - 2 | CardiffCardiff |
| 29 Oct 21 | r00 | ArsenalArsenal | 1 - 3 | Huddersfield TownHuddersfield |
| 29 Oct 21 | r00 | Aston VillaAston Villa | 6 - 2 | MiddlesbroughMiddlesbrough |
| 29 Oct 21 | r00 | BlackburnBlackburn | 1 - 2 | SunderlandSunderland |
| 29 Oct 21 | r00 | BoltonBolton | 1 - 2 | BirminghamBirmingham |
| 29 Oct 21 | r00 | CardiffCardiff | 2 - 0 | West BromWest Brom |
| 29 Oct 21 | r00 | ChelseaChelsea | 4 - 1 | BurnleyBurnley |
| 29 Oct 21 | r00 | LiverpoolLiverpool | 1 - 1 | TottenhamTottenham |
| 29 Oct 21 | r00 | Manchester UnitedManchester Un | 3 - 1 | Manchester CityManchester Ci |
| 29 Oct 21 | r00 | NewcastleNewcastle | 3 - 1 | PrestonPreston |
| 29 Oct 21 | r00 | OldhamOldham | 0 - 0 | EvertonEverton |
| 29 Oct 21 | r00 | Sheffield UnitedSheffield Uni | 1 - 0 | BradfordBradford |
| 05 Nov 21 | r00 | BirminghamBirmingham | 0 - 1 | ArsenalArsenal |
| 05 Nov 21 | r00 | BradfordBradford | 3 - 2 | Aston VillaAston Villa |
| 05 Nov 21 | r00 | BurnleyBurnley | 3 - 3 | PrestonPreston |
| 05 Nov 21 | r00 | CardiffCardiff | 0 - 2 | Manchester CityManchester Ci |
| 05 Nov 21 | r00 | ChelseaChelsea | 0 - 2 | Sheffield UnitedSheffield Uni |
| 05 Nov 21 | r00 | EvertonEverton | 1 - 1 | LiverpoolLiverpool |
| 05 Nov 21 | r00 | Huddersfield TownHuddersfield | 3 - 0 | BlackburnBlackburn |
| 05 Nov 21 | r00 | Manchester UnitedManchester Un | 3 - 5 | MiddlesbroughMiddlesbrough |
| 05 Nov 21 | r00 | SunderlandSunderland | 5 - 1 | OldhamOldham |
| 05 Nov 21 | r00 | TottenhamTottenham | 4 - 0 | NewcastleNewcastle |
| 05 Nov 21 | r00 | West BromWest Brom | 0 - 1 | BoltonBolton |
| 12 Nov 21 | r00 | ArsenalArsenal | 5 - 2 | BirminghamBirmingham |
| 12 Nov 21 | r00 | Aston VillaAston Villa | 7 - 1 | BradfordBradford |
| 12 Nov 21 | r00 | BlackburnBlackburn | 2 - 0 | Huddersfield TownHuddersfield |
| 12 Nov 21 | r00 | BoltonBolton | 2 - 0 | West BromWest Brom |
| 12 Nov 21 | r00 | LiverpoolLiverpool | 1 - 1 | EvertonEverton |
| 12 Nov 21 | r00 | Manchester CityManchester Ci | 1 - 1 | CardiffCardiff |
| 12 Nov 21 | r00 | MiddlesbroughMiddlesbrough | 2 - 0 | Manchester UnitedManchester Un |
| 12 Nov 21 | r00 | NewcastleNewcastle | 0 - 2 | TottenhamTottenham |
| 12 Nov 21 | r00 | OldhamOldham | 3 - 0 | SunderlandSunderland |
| 12 Nov 21 | r00 | PrestonPreston | 2 - 1 | BurnleyBurnley |
| 12 Nov 21 | r00 | Sheffield UnitedSheffield Uni | 1 - 2 | ChelseaChelsea |
| 19 Nov 21 | r00 | Aston VillaAston Villa | 3 - 1 | Manchester UnitedManchester Un |
| 19 Nov 21 | r00 | BlackburnBlackburn | 1 - 1 | BirminghamBirmingham |
| 19 Nov 21 | r00 | BoltonBolton | 1 - 0 | ArsenalArsenal |
| 19 Nov 21 | r00 | CardiffCardiff | 2 - 1 | EvertonEverton |
| 19 Nov 21 | r00 | ChelseaChelsea | 1 - 0 | BradfordBradford |
| 19 Nov 21 | r00 | LiverpoolLiverpool | 4 - 0 | MiddlesbroughMiddlesbrough |
| 19 Nov 21 | r00 | Manchester CityManchester Ci | 6 - 1 | West BromWest Brom |
| 19 Nov 21 | r00 | NewcastleNewcastle | 2 - 2 | SunderlandSunderland |
| 19 Nov 21 | r00 | OldhamOldham | 1 - 1 | Huddersfield TownHuddersfield |
| 19 Nov 21 | r00 | Sheffield UnitedSheffield Uni | 3 - 0 | PrestonPreston |
| 19 Nov 21 | r00 | TottenhamTottenham | 1 - 1 | BurnleyBurnley |
| 26 Nov 21 | r00 | BirminghamBirmingham | 1 - 0 | BlackburnBlackburn |
| 26 Nov 21 | r00 | BradfordBradford | 0 - 1 | ChelseaChelsea |
| 26 Nov 21 | r00 | BurnleyBurnley | 1 - 0 | TottenhamTottenham |
| 26 Nov 21 | r00 | EvertonEverton | 0 - 1 | CardiffCardiff |
| 26 Nov 21 | r00 | Huddersfield TownHuddersfield | 1 - 0 | OldhamOldham |
| 26 Nov 21 | r00 | Manchester UnitedManchester Un | 1 - 0 | Aston VillaAston Villa |
| 26 Nov 21 | r00 | MiddlesbroughMiddlesbrough | 3 - 1 | LiverpoolLiverpool |
| 26 Nov 21 | r00 | PrestonPreston | 3 - 0 | Sheffield UnitedSheffield Uni |
| 26 Nov 21 | r00 | SunderlandSunderland | 0 - 0 | NewcastleNewcastle |
| 26 Nov 21 | r00 | West BromWest Brom | 2 - 0 | Manchester CityManchester Ci |
| 03 Dec 21 | r00 | Aston VillaAston Villa | 1 - 1 | LiverpoolLiverpool |
| 03 Dec 21 | r00 | BlackburnBlackburn | 0 - 1 | ArsenalArsenal |
| 03 Dec 21 | r00 | BradfordBradford | 2 - 1 | Manchester UnitedManchester Un |
| 03 Dec 21 | r00 | CardiffCardiff | 2 - 0 | SunderlandSunderland |
| 03 Dec 21 | r00 | ChelseaChelsea | 0 - 0 | PrestonPreston |
| 03 Dec 21 | r00 | EvertonEverton | 1 - 2 | West BromWest Brom |
| 03 Dec 21 | r00 | Huddersfield TownHuddersfield | 1 - 0 | BurnleyBurnley |
| 03 Dec 21 | r00 | Manchester CityManchester Ci | 2 - 3 | BoltonBolton |
| 03 Dec 21 | r00 | NewcastleNewcastle | 0 - 0 | MiddlesbroughMiddlesbrough |
| 03 Dec 21 | r00 | OldhamOldham | 0 - 1 | BirminghamBirmingham |
| 03 Dec 21 | r00 | TottenhamTottenham | 2 - 1 | Sheffield UnitedSheffield Uni |
| 10 Dec 21 | r00 | ArsenalArsenal | 1 - 1 | BlackburnBlackburn |
| 10 Dec 21 | r00 | BirminghamBirmingham | 3 - 0 | OldhamOldham |
| 10 Dec 21 | r00 | BoltonBolton | 5 - 0 | Manchester CityManchester Ci |
| 10 Dec 21 | r00 | BurnleyBurnley | 1 - 0 | Huddersfield TownHuddersfield |
| 10 Dec 21 | r00 | LiverpoolLiverpool | 2 - 0 | Aston VillaAston Villa |
| 10 Dec 21 | r00 | Manchester UnitedManchester Un | 1 - 1 | BradfordBradford |
| 10 Dec 21 | r00 | MiddlesbroughMiddlesbrough | 1 - 1 | NewcastleNewcastle |
| 10 Dec 21 | r00 | PrestonPreston | 2 - 0 | ChelseaChelsea |
| 10 Dec 21 | r00 | Sheffield UnitedSheffield Uni | 1 - 0 | TottenhamTottenham |
| 10 Dec 21 | r00 | SunderlandSunderland | 4 - 1 | CardiffCardiff |
| 10 Dec 21 | r00 | West BromWest Brom | 1 - 1 | EvertonEverton |
| 12 Dec 21 | r00 | ArsenalArsenal | 1 - 1 | BoltonBolton |
| 17 Dec 21 | r00 | BirminghamBirmingham | 2 - 1 | Sheffield UnitedSheffield Uni |
| 17 Dec 21 | r00 | BlackburnBlackburn | 1 - 2 | BoltonBolton |
| 17 Dec 21 | r00 | BradfordBradford | 1 - 0 | PrestonPreston |
| 17 Dec 21 | r00 | CardiffCardiff | 0 - 0 | Huddersfield TownHuddersfield |
| 17 Dec 21 | r00 | LiverpoolLiverpool | 2 - 1 | Manchester UnitedManchester Un |
| 17 Dec 21 | r00 | Manchester CityManchester Ci | 2 - 1 | EvertonEverton |
| 17 Dec 21 | r00 | MiddlesbroughMiddlesbrough | 4 - 1 | BurnleyBurnley |
| 17 Dec 21 | r00 | NewcastleNewcastle | 1 - 2 | Aston VillaAston Villa |
| 17 Dec 21 | r00 | OldhamOldham | 2 - 1 | ArsenalArsenal |
| 17 Dec 21 | r00 | TottenhamTottenham | 0 - 0 | ChelseaChelsea |
| 17 Dec 21 | r00 | West BromWest Brom | 2 - 1 | SunderlandSunderland |
| 24 Dec 21 | r00 | ArsenalArsenal | 0 - 1 | OldhamOldham |
| 24 Dec 21 | r00 | Aston VillaAston Villa | 1 - 0 | NewcastleNewcastle |
| 24 Dec 21 | r00 | BoltonBolton | 1 - 1 | BlackburnBlackburn |
| 24 Dec 21 | r00 | BurnleyBurnley | 3 - 1 | MiddlesbroughMiddlesbrough |
| 24 Dec 21 | r00 | ChelseaChelsea | 1 - 2 | TottenhamTottenham |
| 24 Dec 21 | r00 | EvertonEverton | 2 - 2 | Manchester CityManchester Ci |
| 24 Dec 21 | r00 | Huddersfield TownHuddersfield | 0 - 1 | CardiffCardiff |
| 24 Dec 21 | r00 | Manchester UnitedManchester Un | 0 - 0 | LiverpoolLiverpool |
| 24 Dec 21 | r00 | PrestonPreston | 2 - 1 | BradfordBradford |
| 24 Dec 21 | r00 | Sheffield UnitedSheffield Uni | 1 - 2 | BirminghamBirmingham |
| 24 Dec 21 | r00 | SunderlandSunderland | 5 - 0 | West BromWest Brom |
| 26 Dec 21 | r00 | ArsenalArsenal | 0 - 0 | CardiffCardiff |
| 26 Dec 21 | r00 | BlackburnBlackburn | 3 - 0 | PrestonPreston |
| 26 Dec 21 | r00 | Huddersfield TownHuddersfield | 2 - 0 | Manchester CityManchester Ci |
| 26 Dec 21 | r00 | LiverpoolLiverpool | 1 - 0 | NewcastleNewcastle |
| 26 Dec 21 | r00 | Manchester UnitedManchester Un | 0 - 1 | BurnleyBurnley |
| 26 Dec 21 | r00 | MiddlesbroughMiddlesbrough | 0 - 1 | ChelseaChelsea |
| 26 Dec 21 | r00 | OldhamOldham | 0 - 0 | BoltonBolton |
| 26 Dec 21 | r00 | Sheffield UnitedSheffield Uni | 2 - 3 | Aston VillaAston Villa |
| 26 Dec 21 | r00 | SunderlandSunderland | 1 - 2 | EvertonEverton |
| 26 Dec 21 | r00 | TottenhamTottenham | 1 - 0 | BradfordBradford |
| 26 Dec 21 | r00 | West BromWest Brom | 1 - 0 | BirminghamBirmingham |
| 27 Dec 21 | r00 | Aston VillaAston Villa | 5 - 3 | Sheffield UnitedSheffield Uni |
| 27 Dec 21 | r00 | BirminghamBirmingham | 0 - 2 | West BromWest Brom |
| 27 Dec 21 | r00 | BradfordBradford | 0 - 4 | TottenhamTottenham |
| 27 Dec 21 | r00 | BurnleyBurnley | 4 - 2 | Manchester UnitedManchester Un |
| 27 Dec 21 | r00 | CardiffCardiff | 4 - 3 | ArsenalArsenal |
| 27 Dec 21 | r00 | ChelseaChelsea | 1 - 1 | MiddlesbroughMiddlesbrough |
| 27 Dec 21 | r00 | LiverpoolLiverpool | 2 - 0 | Huddersfield TownHuddersfield |
| 27 Dec 21 | r00 | PrestonPreston | 2 - 1 | BlackburnBlackburn |
| 31 Dec 21 | r00 | BirminghamBirmingham | 0 - 1 | CardiffCardiff |
| 31 Dec 21 | r00 | BradfordBradford | 0 - 0 | LiverpoolLiverpool |
| 31 Dec 21 | r00 | BurnleyBurnley | 2 - 1 | Aston VillaAston Villa |
| 31 Dec 21 | r00 | ChelseaChelsea | 0 - 2 | ArsenalArsenal |
| 31 Dec 21 | r00 | EvertonEverton | 1 - 0 | BoltonBolton |
| 31 Dec 21 | r00 | Manchester CityManchester Ci | 3 - 0 | SunderlandSunderland |
| 31 Dec 21 | r00 | NewcastleNewcastle | 3 - 0 | Manchester UnitedManchester Un |
| 31 Dec 21 | r00 | OldhamOldham | 1 - 1 | BlackburnBlackburn |
| 31 Dec 21 | r00 | Sheffield UnitedSheffield Uni | 6 - 1 | MiddlesbroughMiddlesbrough |
| 31 Dec 21 | r00 | TottenhamTottenham | 5 - 0 | PrestonPreston |
| 31 Dec 21 | r00 | West BromWest Brom | 3 - 2 | Huddersfield TownHuddersfield |
| 02 Jan 22 | r00 | BlackburnBlackburn | 1 - 3 | CardiffCardiff |
| 02 Jan 22 | r00 | BoltonBolton | 5 - 1 | OldhamOldham |
| 02 Jan 22 | r00 | EvertonEverton | 3 - 0 | SunderlandSunderland |
| 02 Jan 22 | r00 | Manchester CityManchester Ci | 2 - 1 | Huddersfield TownHuddersfield |
| 02 Jan 22 | r00 | NewcastleNewcastle | 1 - 1 | LiverpoolLiverpool |
| 02 Jan 22 | r00 | Sheffield UnitedSheffield Uni | 3 - 0 | Manchester UnitedManchester Un |
| 14 Jan 22 | r00 | ArsenalArsenal | 1 - 0 | ChelseaChelsea |
| 14 Jan 22 | r00 | Aston VillaAston Villa | 2 - 0 | BurnleyBurnley |
| 14 Jan 22 | r00 | BlackburnBlackburn | 3 - 2 | OldhamOldham |
| 14 Jan 22 | r00 | BoltonBolton | 1 - 0 | EvertonEverton |
| 14 Jan 22 | r00 | CardiffCardiff | 3 - 1 | BirminghamBirmingham |
| 14 Jan 22 | r00 | Huddersfield TownHuddersfield | 2 - 0 | West BromWest Brom |
| 14 Jan 22 | r00 | LiverpoolLiverpool | 2 - 1 | BradfordBradford |
| 14 Jan 22 | r00 | Manchester UnitedManchester Un | 0 - 1 | NewcastleNewcastle |
| 14 Jan 22 | r00 | MiddlesbroughMiddlesbrough | 1 - 1 | Sheffield UnitedSheffield Uni |
| 14 Jan 22 | r00 | PrestonPreston | 1 - 2 | TottenhamTottenham |
| 14 Jan 22 | r00 | SunderlandSunderland | 2 - 3 | Manchester CityManchester Ci |
| 18 Jan 22 | r00 | ChelseaChelsea | 0 - 3 | BoltonBolton |
| 21 Jan 22 | r00 | ArsenalArsenal | 0 - 0 | BurnleyBurnley |
| 21 Jan 22 | r00 | BirminghamBirmingham | 0 - 4 | NewcastleNewcastle |
| 21 Jan 22 | r00 | BlackburnBlackburn | 2 - 3 | Sheffield UnitedSheffield Uni |
| 21 Jan 22 | r00 | BoltonBolton | 0 - 2 | ChelseaChelsea |
| 21 Jan 22 | r00 | CardiffCardiff | 6 - 3 | BradfordBradford |
| 21 Jan 22 | r00 | EvertonEverton | 3 - 2 | Aston VillaAston Villa |
| 21 Jan 22 | r00 | Huddersfield TownHuddersfield | 0 - 1 | LiverpoolLiverpool |
| 21 Jan 22 | r00 | Manchester CityManchester Ci | 2 - 2 | MiddlesbroughMiddlesbrough |
| 21 Jan 22 | r00 | OldhamOldham | 2 - 0 | PrestonPreston |
| 21 Jan 22 | r00 | SunderlandSunderland | 2 - 1 | Manchester UnitedManchester Un |
| 21 Jan 22 | r00 | West BromWest Brom | 3 - 0 | TottenhamTottenham |
| 28 Jan 22 | r00 | Manchester UnitedManchester Un | 3 - 1 | SunderlandSunderland |
| 30 Jan 22 | r00 | TottenhamTottenham | 2 - 0 | West BromWest Brom |
| 01 Feb 22 | r00 | MiddlesbroughMiddlesbrough | 4 - 1 | Manchester CityManchester Ci |
| 04 Feb 22 | r00 | ArsenalArsenal | 2 - 1 | NewcastleNewcastle |
| 04 Feb 22 | r00 | BirminghamBirmingham | 0 - 2 | LiverpoolLiverpool |
| 04 Feb 22 | r00 | BlackburnBlackburn | 3 - 2 | BurnleyBurnley |
| 04 Feb 22 | r00 | BoltonBolton | 3 - 1 | Sheffield UnitedSheffield Uni |
| 04 Feb 22 | r00 | CardiffCardiff | 3 - 0 | PrestonPreston |
| 04 Feb 22 | r00 | Manchester CityManchester Ci | 3 - 3 | TottenhamTottenham |
| 04 Feb 22 | r00 | OldhamOldham | 0 - 3 | ChelseaChelsea |
| 04 Feb 22 | r00 | SunderlandSunderland | 1 - 4 | Aston VillaAston Villa |
| 04 Feb 22 | r00 | West BromWest Brom | 1 - 1 | BradfordBradford |
| 08 Feb 22 | r00 | Aston VillaAston Villa | 2 - 1 | EvertonEverton |
| 08 Feb 22 | r00 | CardiffCardiff | 2 - 0 | ChelseaChelsea |
| 08 Feb 22 | r00 | NewcastleNewcastle | 0 - 1 | BirminghamBirmingham |
| 09 Feb 22 | r00 | PrestonPreston | 0 - 0 | OldhamOldham |
| 11 Feb 22 | r00 | Aston VillaAston Villa | 2 - 0 | SunderlandSunderland |
| 11 Feb 22 | r00 | BurnleyBurnley | 1 - 2 | BlackburnBlackburn |
| 11 Feb 22 | r00 | ChelseaChelsea | 1 - 0 | OldhamOldham |
| 11 Feb 22 | r00 | LiverpoolLiverpool | 1 - 0 | BirminghamBirmingham |
| 11 Feb 22 | r00 | Manchester UnitedManchester Un | 1 - 1 | Huddersfield TownHuddersfield |
| 11 Feb 22 | r00 | MiddlesbroughMiddlesbrough | 3 - 1 | EvertonEverton |
| 11 Feb 22 | r00 | NewcastleNewcastle | 3 - 1 | ArsenalArsenal |
| 11 Feb 22 | r00 | PrestonPreston | 1 - 1 | CardiffCardiff |
| 11 Feb 22 | r00 | Sheffield UnitedSheffield Uni | 1 - 0 | BoltonBolton |
| 11 Feb 22 | r00 | TottenhamTottenham | 3 - 1 | Manchester CityManchester Ci |
| 18 Feb 22 | r00 | BirminghamBirmingham | 0 - 1 | Manchester UnitedManchester Un |
| 18 Feb 22 | r00 | BoltonBolton | 0 - 1 | BurnleyBurnley |
| 18 Feb 22 | r00 | OldhamOldham | 0 - 2 | Sheffield UnitedSheffield Uni |
| 18 Feb 22 | r00 | SunderlandSunderland | 1 - 1 | MiddlesbroughMiddlesbrough |
| 20 Feb 22 | r00 | BurnleyBurnley | 1 - 0 | ArsenalArsenal |
| 22 Feb 22 | r00 | Manchester CityManchester Ci | 3 - 2 | BradfordBradford |
| 25 Feb 22 | r00 | Aston VillaAston Villa | 2 - 0 | Huddersfield TownHuddersfield |
| 25 Feb 22 | r00 | BradfordBradford | 1 - 2 | Manchester CityManchester Ci |
| 25 Feb 22 | r00 | BurnleyBurnley | 2 - 0 | BoltonBolton |
| 25 Feb 22 | r00 | ChelseaChelsea | 1 - 0 | CardiffCardiff |
| 25 Feb 22 | r00 | LiverpoolLiverpool | 4 - 0 | ArsenalArsenal |
| 25 Feb 22 | r00 | Manchester UnitedManchester Un | 1 - 1 | BirminghamBirmingham |
| 25 Feb 22 | r00 | MiddlesbroughMiddlesbrough | 3 - 0 | SunderlandSunderland |
| 25 Feb 22 | r00 | NewcastleNewcastle | 2 - 0 | BlackburnBlackburn |
| 25 Feb 22 | r00 | PrestonPreston | 0 - 3 | West BromWest Brom |
| 25 Feb 22 | r00 | Sheffield UnitedSheffield Uni | 1 - 0 | OldhamOldham |
| 25 Feb 22 | r00 | TottenhamTottenham | 2 - 0 | EvertonEverton |
| 27 Feb 22 | r00 | Huddersfield TownHuddersfield | 1 - 1 | Manchester UnitedManchester Un |
| 27 Feb 22 | r00 | Sheffield UnitedSheffield Uni | 0 - 1 | BlackburnBlackburn |
| 01 Mar 22 | r00 | EvertonEverton | 4 - 1 | MiddlesbroughMiddlesbrough |
| 04 Mar 22 | r00 | BlackburnBlackburn | 0 - 0 | LiverpoolLiverpool |
| 04 Mar 22 | r00 | BoltonBolton | 3 - 2 | NewcastleNewcastle |
| 04 Mar 22 | r00 | EvertonEverton | 2 - 0 | BradfordBradford |
| 04 Mar 22 | r00 | OldhamOldham | 0 - 1 | BurnleyBurnley |
| 04 Mar 22 | r00 | SunderlandSunderland | 1 - 0 | Sheffield UnitedSheffield Uni |
| 04 Mar 22 | r00 | West BromWest Brom | 2 - 2 | ChelseaChelsea |
| 06 Mar 22 | r00 | BlackburnBlackburn | 0 - 2 | NewcastleNewcastle |
| 08 Mar 22 | r00 | BradfordBradford | 1 - 1 | West BromWest Brom |
| 11 Mar 22 | r00 | Aston VillaAston Villa | 1 - 1 | BirminghamBirmingham |
| 11 Mar 22 | r00 | BradfordBradford | 3 - 1 | EvertonEverton |
| 11 Mar 22 | r00 | BurnleyBurnley | 0 - 1 | OldhamOldham |
| 11 Mar 22 | r00 | ChelseaChelsea | 1 - 1 | West BromWest Brom |
| 11 Mar 22 | r00 | LiverpoolLiverpool | 2 - 0 | BlackburnBlackburn |
| 11 Mar 22 | r00 | Manchester UnitedManchester Un | 1 - 0 | ArsenalArsenal |
| 11 Mar 22 | r00 | MiddlesbroughMiddlesbrough | 5 - 1 | Huddersfield TownHuddersfield |
| 11 Mar 22 | r00 | NewcastleNewcastle | 2 - 1 | BoltonBolton |
| 11 Mar 22 | r00 | PrestonPreston | 1 - 0 | Manchester CityManchester Ci |
| 11 Mar 22 | r00 | Sheffield UnitedSheffield Uni | 0 - 2 | CardiffCardiff |
| 11 Mar 22 | r00 | TottenhamTottenham | 1 - 0 | SunderlandSunderland |
| 15 Mar 22 | r00 | BirminghamBirmingham | 1 - 0 | Aston VillaAston Villa |
| 15 Mar 22 | r00 | BradfordBradford | 1 - 0 | CardiffCardiff |
| 15 Mar 22 | r00 | EvertonEverton | 0 - 0 | TottenhamTottenham |
| 18 Mar 22 | r00 | Aston VillaAston Villa | 2 - 0 | ArsenalArsenal |
| 18 Mar 22 | r00 | BradfordBradford | 0 - 0 | SunderlandSunderland |
| 18 Mar 22 | r00 | BurnleyBurnley | 1 - 1 | CardiffCardiff |
| 18 Mar 22 | r00 | ChelseaChelsea | 0 - 0 | Manchester CityManchester Ci |
| 18 Mar 22 | r00 | LiverpoolLiverpool | 0 - 2 | BoltonBolton |
| 18 Mar 22 | r00 | Manchester UnitedManchester Un | 0 - 1 | BlackburnBlackburn |
| 18 Mar 22 | r00 | MiddlesbroughMiddlesbrough | 1 - 1 | BirminghamBirmingham |
| 18 Mar 22 | r00 | NewcastleNewcastle | 1 - 1 | OldhamOldham |
| 18 Mar 22 | r00 | PrestonPreston | 1 - 0 | EvertonEverton |
| 18 Mar 22 | r00 | Sheffield UnitedSheffield Uni | 0 - 0 | West BromWest Brom |
| 18 Mar 22 | r00 | TottenhamTottenham | 1 - 0 | Huddersfield TownHuddersfield |
| 22 Mar 22 | r00 | ArsenalArsenal | 1 - 0 | LiverpoolLiverpool |
| 25 Mar 22 | r00 | ArsenalArsenal | 2 - 0 | Aston VillaAston Villa |
| 25 Mar 22 | r00 | BirminghamBirmingham | 4 - 3 | MiddlesbroughMiddlesbrough |
| 25 Mar 22 | r00 | BlackburnBlackburn | 3 - 0 | Manchester UnitedManchester Un |
| 25 Mar 22 | r00 | BoltonBolton | 1 - 3 | LiverpoolLiverpool |
| 25 Mar 22 | r00 | CardiffCardiff | 4 - 2 | BurnleyBurnley |
| 25 Mar 22 | r00 | Manchester CityManchester Ci | 0 - 0 | ChelseaChelsea |
| 25 Mar 22 | r00 | OldhamOldham | 0 - 0 | NewcastleNewcastle |
| 25 Mar 22 | r00 | SunderlandSunderland | 0 - 0 | BradfordBradford |
| 25 Mar 22 | r00 | West BromWest Brom | 3 - 0 | Sheffield UnitedSheffield Uni |
| 27 Mar 22 | r00 | Huddersfield TownHuddersfield | 1 - 1 | TottenhamTottenham |
| 29 Mar 22 | r00 | West BromWest Brom | 2 - 0 | PrestonPreston |
| 01 Apr 22 | r00 | ArsenalArsenal | 2 - 2 | MiddlesbroughMiddlesbrough |
| 01 Apr 22 | r00 | BirminghamBirmingham | 0 - 3 | TottenhamTottenham |
| 01 Apr 22 | r00 | BlackburnBlackburn | 1 - 2 | Aston VillaAston Villa |
| 01 Apr 22 | r00 | BradfordBradford | 4 - 0 | Huddersfield TownHuddersfield |
| 01 Apr 22 | r00 | ChelseaChelsea | 1 - 0 | EvertonEverton |
| 01 Apr 22 | r00 | LiverpoolLiverpool | 2 - 0 | OldhamOldham |
| 01 Apr 22 | r00 | Manchester UnitedManchester Un | 0 - 1 | BoltonBolton |
| 01 Apr 22 | r00 | NewcastleNewcastle | 0 - 0 | CardiffCardiff |
| 01 Apr 22 | r00 | PrestonPreston | 1 - 1 | SunderlandSunderland |
| 01 Apr 22 | r00 | Sheffield UnitedSheffield Uni | 1 - 0 | Manchester CityManchester Ci |
| 01 Apr 22 | r00 | West BromWest Brom | 2 - 0 | BurnleyBurnley |
| 05 Apr 22 | r00 | ArsenalArsenal | 3 - 1 | Manchester UnitedManchester Un |
| 05 Apr 22 | r00 | Huddersfield TownHuddersfield | 1 - 0 | Aston VillaAston Villa |
| 05 Apr 22 | r00 | Manchester CityManchester Ci | 2 - 0 | PrestonPreston |
| 05 Apr 22 | r00 | SunderlandSunderland | 2 - 0 | TottenhamTottenham |
| 08 Apr 22 | r00 | BoltonBolton | 1 - 0 | Manchester UnitedManchester Un |
| 08 Apr 22 | r00 | BurnleyBurnley | 4 - 2 | West BromWest Brom |
| 08 Apr 22 | r00 | CardiffCardiff | 1 - 0 | NewcastleNewcastle |
| 08 Apr 22 | r00 | EvertonEverton | 2 - 3 | ChelseaChelsea |
| 08 Apr 22 | r00 | Huddersfield TownHuddersfield | 1 - 2 | BradfordBradford |
| 08 Apr 22 | r00 | Manchester CityManchester Ci | 2 - 2 | Sheffield UnitedSheffield Uni |
| 08 Apr 22 | r00 | MiddlesbroughMiddlesbrough | 4 - 2 | ArsenalArsenal |
| 08 Apr 22 | r00 | OldhamOldham | 4 - 0 | LiverpoolLiverpool |
| 08 Apr 22 | r00 | SunderlandSunderland | 1 - 0 | PrestonPreston |
| 08 Apr 22 | r00 | TottenhamTottenham | 2 - 1 | BirminghamBirmingham |
| 10 Apr 22 | r00 | ChelseaChelsea | 1 - 0 | Huddersfield TownHuddersfield |
| 10 Apr 22 | r00 | EvertonEverton | 0 - 0 | PrestonPreston |
| 14 Apr 22 | r00 | BurnleyBurnley | 1 - 1 | LiverpoolLiverpool |
| 14 Apr 22 | r00 | ChelseaChelsea | 1 - 0 | Aston VillaAston Villa |
| 14 Apr 22 | r00 | EvertonEverton | 6 - 2 | Huddersfield TownHuddersfield |
| 14 Apr 22 | r00 | Manchester CityManchester Ci | 1 - 0 | BirminghamBirmingham |
| 14 Apr 22 | r00 | NewcastleNewcastle | 1 - 2 | BradfordBradford |
| 14 Apr 22 | r00 | PrestonPreston | 1 - 1 | MiddlesbroughMiddlesbrough |
| 14 Apr 22 | r00 | SunderlandSunderland | 6 - 2 | BoltonBolton |
| 14 Apr 22 | r00 | TottenhamTottenham | 3 - 1 | OldhamOldham |
| 15 Apr 22 | r00 | Aston VillaAston Villa | 2 - 1 | BoltonBolton |
| 15 Apr 22 | r00 | BradfordBradford | 1 - 2 | BirminghamBirmingham |
| 15 Apr 22 | r00 | BurnleyBurnley | 5 - 2 | Manchester CityManchester Ci |
| 15 Apr 22 | r00 | ChelseaChelsea | 1 - 0 | SunderlandSunderland |
| 15 Apr 22 | r00 | LiverpoolLiverpool | 5 - 1 | CardiffCardiff |
| 15 Apr 22 | r00 | Manchester UnitedManchester Un | 0 - 3 | OldhamOldham |
| 15 Apr 22 | r00 | MiddlesbroughMiddlesbrough | 0 - 1 | BlackburnBlackburn |
| 15 Apr 22 | r00 | NewcastleNewcastle | 3 - 0 | West BromWest Brom |
| 15 Apr 22 | r00 | PrestonPreston | 1 - 1 | Huddersfield TownHuddersfield |
| 15 Apr 22 | r00 | Sheffield UnitedSheffield Uni | 1 - 0 | EvertonEverton |
| 15 Apr 22 | r00 | TottenhamTottenham | 2 - 0 | ArsenalArsenal |
| 17 Apr 22 | r00 | Aston VillaAston Villa | 1 - 4 | ChelseaChelsea |
| 17 Apr 22 | r00 | BoltonBolton | 1 - 1 | SunderlandSunderland |
| 17 Apr 22 | r00 | BradfordBradford | 2 - 3 | NewcastleNewcastle |
| 17 Apr 22 | r00 | CardiffCardiff | 1 - 3 | BlackburnBlackburn |
| 17 Apr 22 | r00 | LiverpoolLiverpool | 2 - 1 | BurnleyBurnley |
| 17 Apr 22 | r00 | Manchester UnitedManchester Un | 3 - 2 | Sheffield UnitedSheffield Uni |
| 17 Apr 22 | r00 | MiddlesbroughMiddlesbrough | 1 - 0 | PrestonPreston |
| 17 Apr 22 | r00 | OldhamOldham | 1 - 0 | TottenhamTottenham |
| 17 Apr 22 | r00 | West BromWest Brom | 0 - 3 | ArsenalArsenal |
| 18 Apr 22 | r00 | ArsenalArsenal | 2 - 2 | West BromWest Brom |
| 18 Apr 22 | r00 | BirminghamBirmingham | 3 - 1 | Manchester CityManchester Ci |
| 18 Apr 22 | r00 | Huddersfield TownHuddersfield | 1 - 2 | EvertonEverton |
| 22 Apr 22 | r00 | ArsenalArsenal | 1 - 0 | TottenhamTottenham |
| 22 Apr 22 | r00 | BirminghamBirmingham | 1 - 0 | BradfordBradford |
| 22 Apr 22 | r00 | BlackburnBlackburn | 2 - 2 | MiddlesbroughMiddlesbrough |
| 22 Apr 22 | r00 | BoltonBolton | 1 - 0 | Aston VillaAston Villa |
| 22 Apr 22 | r00 | CardiffCardiff | 2 - 0 | LiverpoolLiverpool |
| 22 Apr 22 | r00 | EvertonEverton | 1 - 1 | Sheffield UnitedSheffield Uni |
| 22 Apr 22 | r00 | Huddersfield TownHuddersfield | 6 - 0 | PrestonPreston |
| 22 Apr 22 | r00 | Manchester CityManchester Ci | 2 - 0 | BurnleyBurnley |
| 22 Apr 22 | r00 | OldhamOldham | 1 - 1 | Manchester UnitedManchester Un |
| 22 Apr 22 | r00 | SunderlandSunderland | 1 - 2 | ChelseaChelsea |
| 22 Apr 22 | r00 | West BromWest Brom | 1 - 2 | NewcastleNewcastle |
| 26 Apr 22 | r00 | CardiffCardiff | 1 - 1 | Sheffield UnitedSheffield Uni |
| 29 Apr 22 | r00 | Aston VillaAston Villa | 2 - 0 | OldhamOldham |
| 29 Apr 22 | r00 | BradfordBradford | 0 - 2 | ArsenalArsenal |
| 29 Apr 22 | r00 | BurnleyBurnley | 2 - 0 | EvertonEverton |
| 29 Apr 22 | r00 | LiverpoolLiverpool | 1 - 2 | West BromWest Brom |
| 29 Apr 22 | r00 | Manchester UnitedManchester Un | 1 - 1 | CardiffCardiff |
| 29 Apr 22 | r00 | MiddlesbroughMiddlesbrough | 4 - 2 | BoltonBolton |
| 29 Apr 22 | r00 | NewcastleNewcastle | 5 - 1 | Manchester CityManchester Ci |
| 29 Apr 22 | r00 | Sheffield UnitedSheffield Uni | 4 - 1 | SunderlandSunderland |
| 29 Apr 22 | r00 | TottenhamTottenham | 2 - 1 | BlackburnBlackburn |
| 01 May 22 | r00 | Huddersfield TownHuddersfield | 2 - 1 | MiddlesbroughMiddlesbrough |
| 01 May 22 | r00 | PrestonPreston | 2 - 2 | BirminghamBirmingham |
| 06 May 22 | r00 | ArsenalArsenal | 1 - 0 | BradfordBradford |
| 06 May 22 | r00 | BirminghamBirmingham | 0 - 2 | PrestonPreston |
| 06 May 22 | r00 | BlackburnBlackburn | 1 - 1 | TottenhamTottenham |
| 06 May 22 | r00 | BoltonBolton | 4 - 2 | MiddlesbroughMiddlesbrough |
| 06 May 22 | r00 | CardiffCardiff | 3 - 1 | Manchester UnitedManchester Un |
| 06 May 22 | r00 | EvertonEverton | 2 - 0 | BurnleyBurnley |
| 06 May 22 | r00 | Huddersfield TownHuddersfield | 2 - 0 | ChelseaChelsea |
| 06 May 22 | r00 | Manchester CityManchester Ci | 1 - 0 | NewcastleNewcastle |
| 06 May 22 | r00 | OldhamOldham | 3 - 1 | Aston VillaAston Villa |
| 06 May 22 | r00 | West BromWest Brom | 1 - 4 | LiverpoolLiverpool |
Team 1921-1922 Schedules
Aberdare Athletic FC
Accrington FC
Bootle FC
Burton Swifts
Burton United FC
Durham City AFC
Glossop North End AFC
Hereford United FC
Leeds City FC
Loughborough FC
Middlesbrough Ironopolis FC
Nelson FC
New Brighton AFC
New Brighton Tower FC
Rotherham Town FC
Scarborough FC
Thames AFC
Wigan Borough FC
Wimbledon FC
Workington AFC
League Table
List
Poster
= TV Listing 
= Event Thumb 
= Banner Image 
= Fanart Image 
= Timeline Details