| 01 Sep 00 | r00  | Aston VillaAston Villa | 2 - 0 | StokeStoke |
| 01 Sep 00 | r00 | BoltonBolton | 0 - 1 | DerbyDerby |
| 01 Sep 00 | r00 | LiverpoolLiverpool | 3 - 0 | BlackburnBlackburn |
| 01 Sep 00 | r00 | Manchester CityManchester Ci | 2 - 2 | Sheffield WedsSheffield Wed |
| 01 Sep 00 | r00 | NewcastleNewcastle | 0 - 0 | Nottingham F.Nottingham F. |
| 01 Sep 00 | r00 | Notts CountyNotts County | 2 - 2 | SunderlandSunderland |
| 01 Sep 00 | r00 | PrestonPreston | 1 - 2 | EvertonEverton |
| 01 Sep 00 | r00 | Sheffield UnitedSheffield Uni | 0 - 3 | BuryBury |
| 01 Sep 00 | r00 | WolvesWolves | 0 - 0 | West BromWest Brom |
| 03 Sep 00 | r00 | Aston VillaAston Villa | 4 - 0 | PrestonPreston |
| 03 Sep 00 | r00 | West BromWest Brom | 1 - 1 | DerbyDerby |
| 03 Sep 00 | r00 | WolvesWolves | 3 - 2 | Notts CountyNotts County |
| 08 Sep 00 | r00 | BlackburnBlackburn | 0 - 0 | NewcastleNewcastle |
| 08 Sep 00 | r00 | BuryBury | 4 - 0 | Manchester CityManchester Ci |
| 08 Sep 00 | r00 | DerbyDerby | 2 - 1 | Notts CountyNotts County |
| 08 Sep 00 | r00 | EvertonEverton | 5 - 1 | WolvesWolves |
| 08 Sep 00 | r00 | Nottingham F.Nottingham F. | 2 - 0 | Sheffield UnitedSheffield Uni |
| 08 Sep 00 | r00 | Sheffield WedsSheffield Wed | 1 - 0 | BoltonBolton |
| 08 Sep 00 | r00 | StokeStoke | 1 - 2 | LiverpoolLiverpool |
| 08 Sep 00 | r00 | SunderlandSunderland | 3 - 1 | PrestonPreston |
| 08 Sep 00 | r00 | West BromWest Brom | 0 - 1 | Aston VillaAston Villa |
| 10 Sep 00 | r00 | Aston VillaAston Villa | 1 - 0 | BuryBury |
| 10 Sep 00 | r00 | StokeStoke | 1 - 1 | Notts CountyNotts County |
| 15 Sep 00 | r00 | Aston VillaAston Villa | 1 - 2 | EvertonEverton |
| 15 Sep 00 | r00 | BuryBury | 2 - 0 | Sheffield WedsSheffield Wed |
| 15 Sep 00 | r00 | LiverpoolLiverpool | 5 - 0 | West BromWest Brom |
| 15 Sep 00 | r00 | Manchester CityManchester Ci | 1 - 0 | Nottingham F.Nottingham F. |
| 15 Sep 00 | r00 | NewcastleNewcastle | 2 - 1 | StokeStoke |
| 15 Sep 00 | r00 | Notts CountyNotts County | 3 - 1 | BoltonBolton |
| 15 Sep 00 | r00 | PrestonPreston | 3 - 2 | DerbyDerby |
| 15 Sep 00 | r00 | Sheffield UnitedSheffield Uni | 2 - 1 | BlackburnBlackburn |
| 15 Sep 00 | r00 | WolvesWolves | 2 - 2 | SunderlandSunderland |
| 22 Sep 00 | r00 | BlackburnBlackburn | 1 - 0 | Manchester CityManchester Ci |
| 22 Sep 00 | r00 | BoltonBolton | 1 - 1 | PrestonPreston |
| 22 Sep 00 | r00 | DerbyDerby | 4 - 5 | WolvesWolves |
| 22 Sep 00 | r00 | EvertonEverton | 1 - 1 | LiverpoolLiverpool |
| 22 Sep 00 | r00 | Nottingham F.Nottingham F. | 1 - 1 | BuryBury |
| 22 Sep 00 | r00 | Sheffield WedsSheffield Wed | 4 - 1 | Notts CountyNotts County |
| 22 Sep 00 | r00 | StokeStoke | 0 - 1 | Sheffield UnitedSheffield Uni |
| 22 Sep 00 | r00 | SunderlandSunderland | 0 - 0 | Aston VillaAston Villa |
| 22 Sep 00 | r00 | West BromWest Brom | 0 - 1 | NewcastleNewcastle |
| 29 Sep 00 | r00 | Aston VillaAston Villa | 2 - 1 | DerbyDerby |
| 29 Sep 00 | r00 | BuryBury | 0 - 1 | BlackburnBlackburn |
| 29 Sep 00 | r00 | LiverpoolLiverpool | 1 - 2 | SunderlandSunderland |
| 29 Sep 00 | r00 | Manchester CityManchester Ci | 2 - 0 | StokeStoke |
| 29 Sep 00 | r00 | NewcastleNewcastle | 1 - 0 | EvertonEverton |
| 29 Sep 00 | r00 | Nottingham F.Nottingham F. | 1 - 0 | Sheffield WedsSheffield Wed |
| 29 Sep 00 | r00 | PrestonPreston | 0 - 1 | Notts CountyNotts County |
| 29 Sep 00 | r00 | Sheffield UnitedSheffield Uni | 1 - 1 | West BromWest Brom |
| 29 Sep 00 | r00 | WolvesWolves | 1 - 1 | BoltonBolton |
| 04 Oct 00 | r00 | Nottingham F.Nottingham F. | 4 - 1 | PrestonPreston |
| 06 Oct 00 | r00 | BlackburnBlackburn | 1 - 3 | Nottingham F.Nottingham F. |
| 06 Oct 00 | r00 | BoltonBolton | 1 - 0 | Aston VillaAston Villa |
| 06 Oct 00 | r00 | DerbyDerby | 2 - 3 | LiverpoolLiverpool |
| 06 Oct 00 | r00 | EvertonEverton | 3 - 1 | Sheffield UnitedSheffield Uni |
| 06 Oct 00 | r00 | Notts CountyNotts County | 4 - 1 | WolvesWolves |
| 06 Oct 00 | r00 | Sheffield WedsSheffield Wed | 0 - 1 | PrestonPreston |
| 06 Oct 00 | r00 | StokeStoke | 1 - 2 | BuryBury |
| 06 Oct 00 | r00 | SunderlandSunderland | 1 - 1 | NewcastleNewcastle |
| 06 Oct 00 | r00 | West BromWest Brom | 3 - 2 | Manchester CityManchester Ci |
| 13 Oct 00 | r00 | Aston VillaAston Villa | 1 - 2 | Notts CountyNotts County |
| 13 Oct 00 | r00 | BlackburnBlackburn | 2 - 2 | Sheffield WedsSheffield Wed |
| 13 Oct 00 | r00 | BuryBury | 6 - 1 | West BromWest Brom |
| 13 Oct 00 | r00 | LiverpoolLiverpool | 2 - 1 | BoltonBolton |
| 13 Oct 00 | r00 | Manchester CityManchester Ci | 1 - 0 | EvertonEverton |
| 13 Oct 00 | r00 | NewcastleNewcastle | 2 - 1 | DerbyDerby |
| 13 Oct 00 | r00 | Nottingham F.Nottingham F. | 1 - 1 | StokeStoke |
| 13 Oct 00 | r00 | Sheffield UnitedSheffield Uni | 2 - 0 | SunderlandSunderland |
| 13 Oct 00 | r00 | WolvesWolves | 2 - 2 | PrestonPreston |
| 20 Oct 00 | r00 | BoltonBolton | 3 - 2 | NewcastleNewcastle |
| 20 Oct 00 | r00 | DerbyDerby | 4 - 0 | Sheffield UnitedSheffield Uni |
| 20 Oct 00 | r00 | Notts CountyNotts County | 3 - 0 | LiverpoolLiverpool |
| 20 Oct 00 | r00 | PrestonPreston | 0 - 2 | Aston VillaAston Villa |
| 20 Oct 00 | r00 | StokeStoke | 2 - 0 | BlackburnBlackburn |
| 20 Oct 00 | r00 | SunderlandSunderland | 3 - 0 | Manchester CityManchester Ci |
| 20 Oct 00 | r00 | West BromWest Brom | 1 - 6 | Nottingham F.Nottingham F. |
| 27 Oct 00 | r00 | Aston VillaAston Villa | 0 - 0 | WolvesWolves |
| 27 Oct 00 | r00 | BlackburnBlackburn | 1 - 1 | West BromWest Brom |
| 27 Oct 00 | r00 | BuryBury | 0 - 0 | SunderlandSunderland |
| 27 Oct 00 | r00 | LiverpoolLiverpool | 3 - 2 | PrestonPreston |
| 27 Oct 00 | r00 | Manchester CityManchester Ci | 2 - 0 | DerbyDerby |
| 27 Oct 00 | r00 | NewcastleNewcastle | 2 - 0 | Notts CountyNotts County |
| 27 Oct 00 | r00 | Nottingham F.Nottingham F. | 2 - 1 | EvertonEverton |
| 27 Oct 00 | r00 | Sheffield UnitedSheffield Uni | 0 - 2 | BoltonBolton |
| 27 Oct 00 | r00 | StokeStoke | 2 - 1 | Sheffield WedsSheffield Wed |
| 29 Oct 00 | r00 | Aston VillaAston Villa | 3 - 3 | BlackburnBlackburn |
| 03 Nov 00 | r00 | BoltonBolton | 0 - 0 | Manchester CityManchester Ci |
| 03 Nov 00 | r00 | DerbyDerby | 5 - 2 | BuryBury |
| 03 Nov 00 | r00 | EvertonEverton | 0 - 0 | BlackburnBlackburn |
| 03 Nov 00 | r00 | Notts CountyNotts County | 2 - 4 | Sheffield UnitedSheffield Uni |
| 03 Nov 00 | r00 | PrestonPreston | 0 - 1 | NewcastleNewcastle |
| 03 Nov 00 | r00 | Sheffield WedsSheffield Wed | 3 - 2 | Aston VillaAston Villa |
| 03 Nov 00 | r00 | SunderlandSunderland | 0 - 1 | Nottingham F.Nottingham F. |
| 03 Nov 00 | r00 | West BromWest Brom | 2 - 2 | StokeStoke |
| 03 Nov 00 | r00 | WolvesWolves | 2 - 1 | LiverpoolLiverpool |
| 05 Nov 00 | r00 | West BromWest Brom | 1 - 0 | Notts CountyNotts County |
| 10 Nov 00 | r00 | BlackburnBlackburn | 0 - 1 | SunderlandSunderland |
| 10 Nov 00 | r00 | BuryBury | 3 - 0 | BoltonBolton |
| 10 Nov 00 | r00 | LiverpoolLiverpool | 5 - 1 | Aston VillaAston Villa |
| 10 Nov 00 | r00 | Manchester CityManchester Ci | 2 - 0 | Notts CountyNotts County |
Team 1900-1901 Schedules
Aberdare Athletic FC
Accrington FC
Bootle FC
Burton Swifts
Burton United FC
Durham City AFC
Glossop North End AFC
Hereford United FC
Leeds City FC
Loughborough FC
Middlesbrough Ironopolis FC
Nelson FC
New Brighton AFC
New Brighton Tower FC
Rotherham Town FC
Scarborough FC
Thames AFC
Wigan Borough FC
Wimbledon FC
Workington AFC
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