| 23 Jul 21 | r01   | PortimonensePortimonense | 2 - 1 | Associação Académica de CAssociação Ac |
| 24 Jul 21 | r01 | TondelaTondela | 0 - 1 | Gil VicenteGil Vicente |
| 24 Jul 21 | r01 | MafraMafra | 1 - 0 | BelenensesBelenenses |
| 24 Jul 21 | r01 | Estrela AmadoraEstrela Amado | 2 - 1 | VizelaVizela |
| 24 Jul 21 | r01 | Academico ViseuAcademico Vis | 1 - 4 | Casa PiaCasa Pia |
| 24 Jul 21 | r01 | FeirenseFeirense | 0 - 1 | FamalicaoFamalicao |
| 24 Jul 21 | r01 | TrofenseTrofense | 0 - 3 | CovilhaCovilha |
| 24 Jul 21 | r01 | ChavesChaves | 1 - 2 | SC FarenseSC Farense |
| 25 Jul 21 | r01 | PenafielPenafiel | 1 - 1 | MoreirenseMoreirense |
| 25 Jul 21 | r01 | VarzimVarzim | 1 - 1 | Rio AveRio Ave |
| 25 Jul 21 | r01 | VilafranquenseVilafranquens | 0 - 3 | AroucaArouca |
| 25 Jul 21 | r01 | CD Nacional de Madeira CD Nacional d | 1 - 2 | Estoril-PraiaEstoril-Praia |
| 25 Jul 21 | r01 | MaritimoMaritimo | 0 - 1 | BoavistaBoavista |
| 26 Jul 21 | r01 | GuimaraesGuimaraes | 4 - 1 | LeixoesLeixoes |
| |
| 30 Jul 21 | r02 | F.C. Paços de FerreiraF.C. Paços de | 1 - 1 | Gil VicenteGil Vicente |
| 01 Aug 21 | r02 | Estrela AmadoraEstrela Amado | 0 - 1 | PenafielPenafiel |
| 01 Aug 21 | r02 | FamalicaoFamalicao | 1 - 0 | Estoril-PraiaEstoril-Praia |
| 01 Aug 21 | r02 | SC FarenseSC Farense | 0 - 0 | Santa ClaraSanta Clara |
| 01 Aug 21 | r02 | CovilhaCovilha | 3 - 1 | MafraMafra |
| 01 Aug 21 | r02 | AroucaArouca | 0 - 1 | Rio AveRio Ave |
| 01 Aug 21 | r02 | Casa PiaCasa Pia | 0 - 1 | GuimaraesGuimaraes |
| 01 Aug 21 | r02 | BoavistaBoavista | 2 - 0 | PortimonensePortimonense |
| |
| 21 Sep 21 | r01 | CovilhaCovilha | 0 - 2 | GuimaraesGuimaraes |
| 22 Sep 21 | r01 | Rio AveRio Ave | 2 - 2 | Santa ClaraSanta Clara |
| 22 Sep 21 | r01 | FamalicaoFamalicao | 5 - 0 | PenafielPenafiel |
| 23 Sep 21 | r01 | F.C. Paços de FerreiraF.C. Paços de | 1 - 2 | BoavistaBoavista |
| |
| 26 Oct 21 | r02 | Santa ClaraSanta Clara | 3 - 1 | FC PortoFC Porto |
| 26 Oct 21 | r02 | Sporting CPSporting CP | 2 - 1 | FamalicaoFamalicao |
| 27 Oct 21 | r02 | GuimaraesGuimaraes | 3 - 3 | BenficaBenfica |
| 28 Oct 21 | r02 | BragaBraga | 0 - 0 | F.C. Paços de FerreiraF.C. Paços de |
| |
| 14 Dec 21 | r03 | PenafielPenafiel | 0 - 1 | Sporting CPSporting CP |
| 15 Dec 21 | r03 | BenficaBenfica | 3 - 0 | CovilhaCovilha |
| 15 Dec 21 | r03 | FC PortoFC Porto | 1 - 0 | Rio AveRio Ave |
| 16 Dec 21 | r03 | BoavistaBoavista | 5 - 1 | BragaBraga |
| |
| 25 Jan 22 | SF    | BenficaBenfica | 1 - 1 | BoavistaBoavista |
| 26 Jan 22 | SF | Sporting CPSporting CP | 2 - 1 | Santa ClaraSanta Clara |
| |
| 29 Jan 22 | Final | BenficaBenfica | 1 - 2 | Sporting CPSporting CP |
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