| 03 Aug 21 | Qualifier    | Neftçi PFKNeftçi PFK | 2 - 2 | HJK HelsinkiHJK Helsinki |
| 05 Aug 21 | Qualifier | Kairat AlmatyKairat Almaty | 0 - 0 | AlashkertAlashkert |
| 05 Aug 21 | Qualifier  | JablonecJablonec | 2 - 4 | CelticCeltic |
| 05 Aug 21 | Qualifier | Omonia NicosiaOmonia Nicosi | 1 - 0 | FC Flora TallinFC Flora Tall |
| 05 Aug 21 | Qualifier | Lincoln Red ImpsLincoln Red I | 1 - 3 | Slovan BratislavaSlovan Bratis |
| 05 Aug 21 | Qualifier | GalatasarayGalatasaray | 1 - 1 | St JohnstoneSt Johnstone |
| 05 Aug 21 | Qualifier | NŠ MuraNŠ Mura | 0 - 0 | VMFD ZalgirisVMFD Zalgiris |
| 05 Aug 21 | Qualifier | Rapid ViennaRapid Vienna | 3 - 0 | Anorthosis FamagustaAnorthosis Fa |
| 10 Aug 21 | Qualifier | FC Flora TallinFC Flora Tall | 2 - 1 | Omonia NicosiaOmonia Nicosi |
| 10 Aug 21 | Qualifier | Slovan BratislavaSlovan Bratis | 1 - 1 | Lincoln Red ImpsLincoln Red I |
| 12 Aug 21 | Qualifier | AlashkertAlashkert | 3 - 2 | Kairat AlmatyKairat Almaty |
| 12 Aug 21 | Qualifier | HJK HelsinkiHJK Helsinki | 3 - 0 | Neftçi PFKNeftçi PFK |
| 12 Aug 21 | Qualifier | VMFD ZalgirisVMFD Zalgiris | 0 - 1 | NŠ MuraNŠ Mura |
| 12 Aug 21 | Qualifier | Anorthosis FamagustaAnorthosis Fa | 2 - 1 | Rapid ViennaRapid Vienna |
| 12 Aug 21 | Qualifier | St JohnstoneSt Johnstone | 2 - 4 | GalatasarayGalatasaray |
| 12 Aug 21 | Qualifier | CelticCeltic | 3 - 0 | JablonecJablonec |
| 17 Aug 21 | Qualifier | Crvena ZvezdaCrvena Zvezda | 4 - 0 | CFR Cluj-NapocaCFR Cluj-Napo |
| 18 Aug 21 | Qualifier | CelticCeltic | 2 - 0 | AZ AlkmaarAZ Alkmaar |
| 19 Aug 21 | Qualifier | Omonia NicosiaOmonia Nicosi | 4 - 2 | AntwerpAntwerp |
| 19 Aug 21 | Qualifier | Slavia PragueSlavia Prague | 2 - 2 | Legia WarsawLegia Warsaw |
| 19 Aug 21 | Qualifier | Randers FCRanders FC | 1 - 1 | GalatasarayGalatasaray |
| 19 Aug 21 | Qualifier | NŠ MuraNŠ Mura | 1 - 3 | Sturm GrazSturm Graz |
| 19 Aug 21 | Qualifier | FenerbahceFenerbahce | 1 - 0 | HJK HelsinkiHJK Helsinki |
| 19 Aug 21 | Qualifier | OlympiakosOlympiakos | 3 - 0 | Slovan BratislavaSlovan Bratis |
| 19 Aug 21 | Qualifier | Rapid ViennaRapid Vienna | 3 - 0 | ZoryaZorya |
| 19 Aug 21 | Qualifier | RangersRangers | 1 - 0 | AlashkertAlashkert |
| 26 Aug 21 | Qualifier | AlashkertAlashkert | 0 - 0 | RangersRangers |
| 26 Aug 21 | Qualifier | HJK HelsinkiHJK Helsinki | 2 - 5 | FenerbahceFenerbahce |
| 26 Aug 21 | Qualifier | ZoryaZorya | 2 - 3 | Rapid ViennaRapid Vienna |
| 26 Aug 21 | Qualifier | Slovan BratislavaSlovan Bratis | 2 - 2 | OlympiakosOlympiakos |
| 26 Aug 21 | Qualifier | GalatasarayGalatasaray | 2 - 1 | Randers FCRanders FC |
| 26 Aug 21 | Qualifier | AZ AlkmaarAZ Alkmaar | 2 - 1 | CelticCeltic |
| 26 Aug 21 | Qualifier | CFR Cluj-NapocaCFR Cluj-Napo | 1 - 2 | Crvena ZvezdaCrvena Zvezda |
| 26 Aug 21 | Qualifier | AntwerpAntwerp | 2 - 0 | Omonia NicosiaOmonia Nicosi |
| 26 Aug 21 | Qualifier | Legia WarsawLegia Warsaw | 2 - 1 | Slavia PragueSlavia Prague |
| 26 Aug 21 | Qualifier | Sturm GrazSturm Graz | 2 - 0 | NŠ MuraNŠ Mura |
| |
| 15 Sep 21 | r01 | Spartak MoscowSpartak Mosco | 0 - 1 | Legia WarsawLegia Warsaw |
| 16 Sep 21 | r01 | Crvena ZvezdaCrvena Zvezda | 2 - 1 | BragaBraga |
| 16 Sep 21 | r01 | FC MidtjyllandFC Midtjyllan | 1 - 1 | Ludogorets RazgradLudogorets Ra |
| 16 Sep 21 | r01 | GalatasarayGalatasaray | 1 - 0 | LazioLazio |
| 16 Sep 21 | r01 | Lok. MoscowLok. Moscow | 1 - 1 | MarseilleMarseille |
| 16 Sep 21 | r01 | LeverkusenLeverkusen | 2 - 1 | FerencvarosFerencvaros |
| 16 Sep 21 | r01 | BetisBetis | 4 - 3 | CelticCeltic |
| 16 Sep 21 | r01 | Dinamo ZagrebDinamo Zagreb | 0 - 2 | West HamWest Ham |
| 16 Sep 21 | r01 | Rapid ViennaRapid Vienna | 0 - 1 | GenkGenk |
| 16 Sep 21 | r01 | Ein FrankfurtEin Frankfurt | 1 - 1 | FenerbahceFenerbahce |
| 16 Sep 21 | r01 | RangersRangers | 0 - 2 | LyonLyon |
| 16 Sep 21 | r01 | BrøndbyBrøndby | 0 - 0 | Sparta PragueSparta Prague |
| 16 Sep 21 | r01 | PSV EindhovenPSV Eindhoven | 2 - 2 | SociedadSociedad |
| 16 Sep 21 | r01 | MonacoMonaco | 1 - 0 | Sturm GrazSturm Graz |
| 16 Sep 21 | r01 | LeicesterLeicester | 2 - 2 | NapoliNapoli |
| 16 Sep 21 | r01 | OlympiakosOlympiakos | 2 - 1 | AntwerpAntwerp |
| |
| 30 Sep 21 | r02 | Sparta PragueSparta Prague | 1 - 0 | RangersRangers |
| 30 Sep 21 | r02 | NapoliNapoli | 2 - 3 | Spartak MoscowSpartak Mosco |
| 30 Sep 21 | r02 | LyonLyon | 3 - 0 | BrøndbyBrøndby |
| 30 Sep 21 | r02 | SociedadSociedad | 1 - 1 | MonacoMonaco |
| 30 Sep 21 | r02 | Sturm GrazSturm Graz | 1 - 4 | PSV EindhovenPSV Eindhoven |
| 30 Sep 21 | r02 | Legia WarsawLegia Warsaw | 1 - 0 | LeicesterLeicester |
| 30 Sep 21 | r02 | AntwerpAntwerp | 0 - 1 | Ein FrankfurtEin Frankfurt |
| 30 Sep 21 | r02 | FenerbahceFenerbahce | 0 - 3 | OlympiakosOlympiakos |
| 30 Sep 21 | r02 | GenkGenk | 0 - 3 | Dinamo ZagrebDinamo Zagreb |
| 30 Sep 21 | r02 | Ludogorets RazgradLudogorets Ra | 0 - 1 | Crvena ZvezdaCrvena Zvezda |
| 30 Sep 21 | r02 | BragaBraga | 3 - 1 | FC MidtjyllandFC Midtjyllan |
| 30 Sep 21 | r02 | LazioLazio | 2 - 0 | Lok. MoscowLok. Moscow |
| 30 Sep 21 | r02 | MarseilleMarseille | 0 - 0 | GalatasarayGalatasaray |
| 30 Sep 21 | r02 | CelticCeltic | 0 - 4 | LeverkusenLeverkusen |
| 30 Sep 21 | r02 | FerencvarosFerencvaros | 1 - 3 | BetisBetis |
| 30 Sep 21 | r02 | West HamWest Ham | 2 - 0 | Rapid ViennaRapid Vienna |
| |
| 19 Oct 21 | r03 | CelticCeltic | 2 - 0 | FerencvarosFerencvaros |
| 20 Oct 21 | r03 | Spartak MoscowSpartak Mosco | 3 - 4 | LeicesterLeicester |
| 21 Oct 21 | r03 | FenerbahceFenerbahce | 2 - 2 | AntwerpAntwerp |
| 21 Oct 21 | r03 | Ludogorets RazgradLudogorets Ra | 0 - 1 | BragaBraga |
| 21 Oct 21 | r03 | FC MidtjyllandFC Midtjyllan | 1 - 1 | Crvena ZvezdaCrvena Zvezda |
| 21 Oct 21 | r03 | LazioLazio | 0 - 0 | MarseilleMarseille |
| 21 Oct 21 | r03 | BetisBetis | 1 - 1 | LeverkusenLeverkusen |
| 21 Oct 21 | r03 | Rapid ViennaRapid Vienna | 2 - 1 | Dinamo ZagrebDinamo Zagreb |
| 21 Oct 21 | r03 | Sparta PragueSparta Prague | 3 - 4 | LyonLyon |
| 21 Oct 21 | r03 | NapoliNapoli | 3 - 0 | Legia WarsawLegia Warsaw |
| 21 Oct 21 | r03 | Ein FrankfurtEin Frankfurt | 3 - 1 | OlympiakosOlympiakos |
| 21 Oct 21 | r03 | RangersRangers | 2 - 0 | BrøndbyBrøndby |
| 21 Oct 21 | r03 | PSV EindhovenPSV Eindhoven | 1 - 2 | MonacoMonaco |
| 21 Oct 21 | r03 | Sturm GrazSturm Graz | 0 - 1 | SociedadSociedad |
| 21 Oct 21 | r03 | Lok. MoscowLok. Moscow | 0 - 1 | GalatasarayGalatasaray |
| 21 Oct 21 | r03 | West HamWest Ham | 3 - 0 | GenkGenk |
| |
| 04 Nov 21 | r04 | LyonLyon | 3 - 0 | Sparta PragueSparta Prague |
| 04 Nov 21 | r04 | BrøndbyBrøndby | 1 - 1 | RangersRangers |
| 04 Nov 21 | r04 | SociedadSociedad | 1 - 1 | Sturm GrazSturm Graz |
| 04 Nov 21 | r04 | MonacoMonaco | 0 - 0 | PSV EindhovenPSV Eindhoven |
| 04 Nov 21 | r04 | Legia WarsawLegia Warsaw | 1 - 4 | NapoliNapoli |
| 04 Nov 21 | r04 | OlympiakosOlympiakos | 1 - 2 | Ein FrankfurtEin Frankfurt |
| 04 Nov 21 | r04 | GalatasarayGalatasaray | 1 - 1 | Lok. MoscowLok. Moscow |
| 04 Nov 21 | r04 | GenkGenk | 2 - 2 | West HamWest Ham |
| 04 Nov 21 | r04 | LeicesterLeicester | 1 - 1 | Spartak MoscowSpartak Mosco |
| 04 Nov 21 | r04 | AntwerpAntwerp | 0 - 3 | FenerbahceFenerbahce |
| 04 Nov 21 | r04 | BragaBraga | 4 - 2 | Ludogorets RazgradLudogorets Ra |
| 04 Nov 21 | r04 | Crvena ZvezdaCrvena Zvezda | 0 - 1 | FC MidtjyllandFC Midtjyllan |
| 04 Nov 21 | r04 | MarseilleMarseille | 2 - 2 | LazioLazio |
| 04 Nov 21 | r04 | LeverkusenLeverkusen | 4 - 0 | BetisBetis |
| 04 Nov 21 | r04 | FerencvarosFerencvaros | 2 - 3 | CelticCeltic |
| 04 Nov 21 | r04 | Dinamo ZagrebDinamo Zagreb | 3 - 1 | Rapid ViennaRapid Vienna |
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