| 09 Sep 22 | r02        | UCFUCF | 14 - 20 | LouisvilleLouisville |
| 10 Sep 22 | r02        | New MexicoNew Mexico | 14 - 31 | Boise StateBoise State |
| 10 Sep 22 | r02        | ArkansasArkansas | 44 - 30 | South CarolinaSouth Carolin |
| 10 Sep 22 | r02        | ArmyArmy | 38 - 41 | UTSAUTSA |
| 10 Sep 22 | r02        | Georgia StateGeorgia State | 28 - 35 | North CarolinaNorth Carolin |
| 10 Sep 22 | r02        | Kansas StateKansas State | 40 - 12 | MissouriMissouri |
| 10 Sep 22 | r02        | Miami (FL)Miami (FL) | 30 - 7 | Southern MissSouthern Miss |
| 10 Sep 22 | r02        | MinnesotaMinnesota | 62 - 10 | Western IllinoisWestern Illin |
| 10 Sep 22 | r02        | NorthwesternNorthwestern | 23 - 31 | DukeDuke |
| 10 Sep 22 | r02        | Ohio StateOhio State | 45 - 12 | Arkansas StateArkansas Stat |
| 10 Sep 22 | r02        | Penn StatePenn State | 46 - 10 | OhioOhio |
| 10 Sep 22 | r02        | TexasTexas | 19 - 20 | AlabamaAlabama |
| 10 Sep 22 | r02        | VanderbiltVanderbilt | 25 - 45 | Wake ForestWake Forest |
| 10 Sep 22 | r02        | NC StateNC State | 55 - 3 | Charleston SouthernCharleston So |
| 10 Sep 22 | r02        | Central MichiganCentral Michi | 24 - 38 | South AlabamaSouth Alabama |
| 10 Sep 22 | r02        | UtahUtah | 73 - 7 | Southern UtahSouthern Utah |
| 10 Sep 22 | r02        | Ball StateBall State | 30 - 37 | Western MichiganWestern Michi |
| 10 Sep 22 | r02        | TempleTemple | 30 - 14 | LafayetteLafayette |
| 10 Sep 22 | r02        | Youngstown StateYoungstown St | 49 - 16 | DaytonDayton |
| 10 Sep 22 | r02        | Notre DameNotre Dame | 21 - 26 | MarshallMarshall |
| 10 Sep 22 | r02        | Air ForceAir Force | 41 - 10 | ColoradoColorado |
| 10 Sep 22 | r02        | CharlotteCharlotte | 21 - 56 | MarylandMaryland |
| 10 Sep 22 | r02        | CincinnatiCincinnati | 63 - 10 | Kennesaw StateKennesaw Stat |
| 10 Sep 22 | r02        | ClemsonClemson | 35 - 12 | FurmanFurman |
| 10 Sep 22 | r02        | NavyNavy | 13 - 37 | MemphisMemphis |
| 10 Sep 22 | r02        | PittsburghPittsburgh | 27 - 34 | TennesseeTennessee |
| 10 Sep 22 | r02        | Texas A&MTexas A&M | 14 - 17 | Appalachian StateAppalachian S |
| 10 Sep 22 | r02        | WisconsinWisconsin | 14 - 17 | Washington StateWashington St |
| 10 Sep 22 | r02        | Bowling GreenBowling Green | 57 - 59 | Eastern KentuckyEastern Kentu |
| 10 Sep 22 | r02        | CaliforniaCalifornia | 20 - 14 | UNLVUNLV |
| 10 Sep 22 | r02        | Colorado StateColorado Stat | 19 - 34 | Middle TennesseeMiddle Tennes |
| 10 Sep 22 | r02        | GeorgiaGeorgia | 33 - 0 | SamfordSamford |
| 10 Sep 22 | r02        | IllinoisIllinois | 24 - 3 | VirginiaVirginia |
| 10 Sep 22 | r02        | IowaIowa | 7 - 10 | Iowa StateIowa State |
| 10 Sep 22 | r02        | James MadisonJames Madison | 63 - 7 | Norfolk StateNorfolk State |
| 10 Sep 22 | r02        | Michigan StateMichigan Stat | 52 - 0 | AkronAkron |
| 10 Sep 22 | r02        | PurduePurdue | 56 - 0 | Indiana StateIndiana State |
| 10 Sep 22 | r02        | RutgersRutgers | 66 - 7 | WagnerWagner |
| 10 Sep 22 | r02        | Texas TechTexas Tech | 33 - 30 | HoustonHouston |
| 10 Sep 22 | r02        | WashingtonWashington | 52 - 6 | Portland StatePortland Stat |
| 10 Sep 22 | r02        | WyomingWyoming | 33 - 10 | Northern ColoradoNorthern Colo |
| 10 Sep 22 | r02        | UCLAUCLA | 45 - 7 | Alabama StateAlabama State |
| 10 Sep 22 | r02        | NevadaNevada | 41 - 55 | Incarnate WordIncarnate Wor |
| 10 Sep 22 | r02        | BuffaloBuffalo | 31 - 37 | Holy CrossHoly Cross |
| 10 Sep 22 | r02        | Coastal CarolinaCoastal Carol | 31 - 27 | Gardner-WebbGardner-Webb |
| 10 Sep 22 | r02        | East CarolinaEast Carolina | 39 - 21 | Old DominionOld Dominion |
| 10 Sep 22 | r02        | Florida AtlanticFlorida Atlan | 42 - 9 | Southeastern LouisianaSoutheastern |
| 10 Sep 22 | r02        | LibertyLiberty | 21 - 14 | UABUAB |
| 10 Sep 22 | r02        | Miami (OH)Miami (OH) | 31 - 14 | Robert MorrisRobert Morris |
| 10 Sep 22 | r02        | West VirginiaWest Virginia | 42 - 55 | KansasKansas |
| 10 Sep 22 | r02        | Utah StateUtah State | 7 - 35 | Weber StateWeber State |
| 10 Sep 22 | r02        | UConnUConn | 14 - 48 | SyracuseSyracuse |
| 10 Sep 22 | r02        | FloridaFlorida | 16 - 26 | KentuckyKentucky |
| 10 Sep 22 | r02        | Georgia TechGeorgia Tech | 35 - 17 | Western CarolinaWestern Carol |
| 10 Sep 22 | r02        | Louisiana TechLouisiana Tec | 52 - 17 | Stephen F. AustinStephen F. Au |
| 10 Sep 22 | r02        | LouisianaLouisiana | 49 - 21 | Eastern MichiganEastern Michi |
| 10 Sep 22 | r02        | OklahomaOklahoma | 33 - 3 | Kent StateKent State |
| 10 Sep 22 | r02        | Ole MissOle Miss | 59 - 3 | Central ArkansasCentral Arkan |
| 10 Sep 22 | r02        | South FloridaSouth Florida | 42 - 20 | HowardHoward |
| 10 Sep 22 | r02        | SMUSMU | 45 - 16 | LamarLamar |
| 10 Sep 22 | r02        | Texas StateTexas State | 41 - 12 | FIUFIU |
| 10 Sep 22 | r02        | ToledoToledo | 55 - 10 | UMassUMass |
| 10 Sep 22 | r02        | TroyTroy | 38 - 17 | Alabama A&MAlabama A&M |
| 10 Sep 22 | r02        | TulaneTulane | 52 - 0 | Alcorn StateAlcorn State |
| 10 Sep 22 | r02        | TulsaTulsa | 38 - 35 | Northern IllinoisNorthern Illi |
| 10 Sep 22 | r02        | AuburnAuburn | 24 - 16 | San Jose StateSan Jose Stat |
| 10 Sep 22 | r02        | LSULSU | 65 - 17 | SouthernSouthern |
| 10 Sep 22 | r02        | NebraskaNebraska | 42 - 45 | Georgia SouthernGeorgia South |
| 10 Sep 22 | r02        | North TexasNorth Texas | 59 - 27 | Texas SouthernTexas Souther |
| 10 Sep 22 | r02        | Oklahoma StateOklahoma Stat | 34 - 17 | Arizona StateArizona State |
| 10 Sep 22 | r02        | RiceRice | 52 - 10 | McNeese StateMcNeese State |
| 10 Sep 22 | r02        | StanfordStanford | 28 - 41 | USCUSC |
| 11 Sep 22 | r02        | San Diego StateSan Diego Sta | 38 - 7 | Idaho StateIdaho State |
| 11 Sep 22 | r02        | IndianaIndiana | 35 - 22 | IdahoIdaho |
| 11 Sep 22 | r02        | Louisiana-MonroeLouisiana-Mon | 35 - 7 | NichollsNicholls |
| 11 Sep 22 | r02        | TCUTCU | 59 - 17 | Tarleton StateTarleton Stat |
| 11 Sep 22 | r02        | Virginia TechVirginia Tech | 27 - 10 | Boston CollegeBoston Colleg |
| 11 Sep 22 | r02        | OregonOregon | 70 - 14 | Eastern WashingtonEastern Washi |
| 11 Sep 22 | r02        | UTEPUTEP | 20 - 13 | New Mexico StateNew Mexico St |
| 11 Sep 22 | r02        | BYUBYU | 26 - 20 | BaylorBaylor |
| 11 Sep 22 | r02        | Fresno StateFresno State | 32 - 35 | Oregon StateOregon State |
| 11 Sep 22 | r02        | ArizonaArizona | 17 - 39 | Mississippi StateMississippi S |
| 12 Sep 22 | r02        | MichiganMichigan | 56 - 10 | HawaiiHawaii |