| 27 Aug 22 | r00        | Western KentuckyWestern Kentu | 38 - 27 | Austin PeayAustin Peay |
| 27 Aug 22 | r00        | NebraskaNebraska | 28 - 31 | NorthwesternNorthwestern |
| 27 Aug 22 | r00        | UNLVUNLV | 52 - 21 | Idaho StateIdaho State |
| 27 Aug 22 | r00        | IllinoisIllinois | 38 - 6 | WyomingWyoming |
| 27 Aug 22 | r00        | Utah StateUtah State | 31 - 20 | UConnUConn |
| 27 Aug 22 | r00        | Florida StateFlorida State | 47 - 7 | DuquesneDuquesne |
| 27 Aug 22 | r00        | Florida AtlanticFlorida Atlan | 43 - 13 | CharlotteCharlotte |
| 28 Aug 22 | r00        | North CarolinaNorth Carolin | 56 - 24 | Florida A&MFlorida A&M |
| 28 Aug 22 | r00        | UTEPUTEP | 13 - 31 | North TexasNorth Texas |
| 28 Aug 22 | r00        | New Mexico StateNew Mexico St | 12 - 23 | NevadaNevada |
| 28 Aug 22 | r00        | HawaiiHawaii | 10 - 63 | VanderbiltVanderbilt |
| |
| 01 Sep 22 | r01        | AkronAkron | 30 - 23 | Saint FrancisSaint Francis |
| 01 Sep 22 | r01        | FIUFIU | 38 - 37 | BryantBryant |
| 01 Sep 22 | r01        | Oklahoma StateOklahoma Stat | 58 - 44 | Central MichiganCentral Michi |
| 01 Sep 22 | r01        | PittsburghPittsburgh | 38 - 31 | West VirginiaWest Virginia |
| 01 Sep 22 | r01        | TennesseeTennessee | 59 - 10 | Ball StateBall State |
| 01 Sep 22 | r01        | ToledoToledo | 37 - 0 | Long IslandLong Island |
| 01 Sep 22 | r01        | UCFUCF | 56 - 10 | South Carolina StateSouth Carolin |
| 01 Sep 22 | r01        | Wake ForestWake Forest | 44 - 10 | VMIVMI |
| 02 Sep 22 | r01        | MissouriMissouri | 52 - 24 | Louisiana TechLouisiana Tec |
| 02 Sep 22 | r01        | Northern IllinoisNorthern Illi | 34 - 27 | Eastern IllinoisEastern Illin |
| 02 Sep 22 | r01        | PurduePurdue | 31 - 35 | Penn StatePenn State |
| 02 Sep 22 | r01        | UABUAB | 59 - 0 | Alabama A&MAlabama A&M |
| 02 Sep 22 | r01        | MinnesotaMinnesota | 38 - 0 | New Mexico StateNew Mexico St |
| 02 Sep 22 | r01        | Arizona StateArizona State | 40 - 3 | Northern ArizonaNorthern Ariz |
| 02 Sep 22 | r01        | Fresno StateFresno State | 35 - 7 | Cal PolyCal Poly |
| 02 Sep 22 | r01        | San Jose StateSan Jose Stat | 21 - 17 | Portland StatePortland Stat |
| 02 Sep 22 | r01        | CharlotteCharlotte | 24 - 41 | William & MaryWilliam & Mar |
| 02 Sep 22 | r01        | Eastern MichiganEastern Michi | 42 - 34 | Eastern KentuckyEastern Kentu |
| 02 Sep 22 | r01        | Michigan StateMichigan Stat | 35 - 13 | Western MichiganWestern Michi |
| |
| 02 Sep 22 | r00        | Old DominionOld Dominion | 20 - 17 | Virginia TechVirginia Tech |
| |
| 02 Sep 22 | r01        | DukeDuke | 30 - 0 | TempleTemple |
| 03 Sep 22 | r01        | IndianaIndiana | 23 - 20 | IllinoisIllinois |
| 03 Sep 22 | r01        | KansasKansas | 56 - 10 | Tennessee TechTennessee Tec |
| 03 Sep 22 | r01        | Montana StateMontana State | 40 - 17 | McNeese StateMcNeese State |
| 03 Sep 22 | r01        | ColoradoColorado | 13 - 38 | TCUTCU |
| 03 Sep 22 | r01        | Appalachian StateAppalachian S | 61 - 63 | North CarolinaNorth Carolin |
| 03 Sep 22 | r01        | Boston CollegeBoston Colleg | 21 - 22 | RutgersRutgers |
| 03 Sep 22 | r01        | UConnUConn | 28 - 3 | Central ConnecticutCentral Conne |
| 03 Sep 22 | r01        | East CarolinaEast Carolina | 20 - 21 | NC StateNC State |
| 03 Sep 22 | r01        | IowaIowa | 7 - 3 | South Dakota StateSouth Dakota |
| 03 Sep 22 | r01        | MarylandMaryland | 31 - 10 | BuffaloBuffalo |
| 03 Sep 22 | r01        | MichiganMichigan | 51 - 7 | Colorado StateColorado Stat |
| 03 Sep 22 | r01        | NavyNavy | 7 - 14 | DelawareDelaware |
| 03 Sep 22 | r01        | Texas A&MTexas A&M | 31 - 0 | Sam Houston StateSam Houston S |
| 03 Sep 22 | r01        | VirginiaVirginia | 34 - 17 | RichmondRichmond |
| 03 Sep 22 | r01        | Air ForceAir Force | 48 - 17 | Northern IowaNorthern Iowa |
| 03 Sep 22 | r01        | Iowa StateIowa State | 42 - 10 | Southeast Missouri StateSoutheast Mis |
| 03 Sep 22 | r01        | Youngstown StateYoungstown St | - | DuquesneDuquesne |
| 03 Sep 22 | r01        | UCLAUCLA | 45 - 17 | Bowling GreenBowling Green |
| 03 Sep 22 | r01        | ArkansasArkansas | 31 - 24 | CincinnatiCincinnati |
| 03 Sep 22 | r01        | GeorgiaGeorgia | 49 - 3 | OregonOregon |
| |
| 03 Sep 22 | r00        | MarshallMarshall | 55 - 3 | Norfolk StateNorfolk State |
| |
| 03 Sep 22 | r01        | Miami (FL)Miami (FL) | 70 - 13 | Bethune-CookmanBethune-Cookm |
| 03 Sep 22 | r01        | NebraskaNebraska | 38 - 17 | North DakotaNorth Dakota |
| 03 Sep 22 | r01        | OklahomaOklahoma | 45 - 13 | UTEPUTEP |
| 03 Sep 22 | r01        | San Diego StateSan Diego Sta | 20 - 38 | ArizonaArizona |
| 03 Sep 22 | r01        | UTSAUTSA | 35 - 37 | HoustonHouston |
| 03 Sep 22 | r01        | WyomingWyoming | 40 - 37 | TulsaTulsa |
| 03 Sep 22 | r01        | CaliforniaCalifornia | 34 - 13 | UC DavisUC Davis |
| 03 Sep 22 | r01        | Ole MissOle Miss | 28 - 10 | TroyTroy |
| 03 Sep 22 | r01        | South FloridaSouth Florida | 21 - 50 | BYUBYU |
| 03 Sep 22 | r01        | South AlabamaSouth Alabama | 48 - 7 | NichollsNicholls |
| 03 Sep 22 | r01        | NevadaNevada | 38 - 14 | Texas StateTexas State |
| 03 Sep 22 | r01        | Georgia SouthernGeorgia South | 59 - 7 | Morgan StateMorgan State |
| 03 Sep 22 | r01        | James MadisonJames Madison | 44 - 7 | Middle TennesseeMiddle Tennes |
| 03 Sep 22 | r01        | OhioOhio | 41 - 38 | Florida AtlanticFlorida Atlan |
| 03 Sep 22 | r01        | USCUSC | 66 - 14 | RiceRice |
| 03 Sep 22 | r01        | Arkansas StateArkansas Stat | 58 - 3 | Grambling StateGrambling Sta |
| 03 Sep 22 | r01        | AuburnAuburn | 42 - 16 | MercerMercer |
| 03 Sep 22 | r01        | BaylorBaylor | 69 - 10 | AlbanyAlbany |
| 03 Sep 22 | r01        | Coastal CarolinaCoastal Carol | 38 - 28 | ArmyArmy |
| 03 Sep 22 | r01        | FloridaFlorida | 29 - 26 | UtahUtah |
| 03 Sep 22 | r01        | Kansas StateKansas State | 34 - 0 | South DakotaSouth Dakota |
| 03 Sep 22 | r01        | KentuckyKentucky | 37 - 13 | Miami (OH)Miami (OH) |
| 03 Sep 22 | r01        | LouisianaLouisiana | 24 - 7 | Southeastern LouisianaSoutheastern |
| 03 Sep 22 | r01        | Southern MissSouthern Miss | 27 - 29 | LibertyLiberty |
| 03 Sep 22 | r01        | TulaneTulane | 42 - 10 | UMassUMass |
| 03 Sep 22 | r01        | VanderbiltVanderbilt | 42 - 31 | ElonElon |
| 03 Sep 22 | r01        | WisconsinWisconsin | 38 - 0 | Illinois StateIllinois Stat |
| 03 Sep 22 | r01        | AlabamaAlabama | 55 - 0 | Utah StateUtah State |
| 03 Sep 22 | r01        | Mississippi StateMississippi S | 49 - 23 | MemphisMemphis |
| 03 Sep 22 | r01        | North TexasNorth Texas | 10 - 48 | SMUSMU |
| 03 Sep 22 | r01        | Ohio StateOhio State | 21 - 10 | Notre DameNotre Dame |
| 03 Sep 22 | r01        | South CarolinaSouth Carolin | 35 - 14 | Georgia StateGeorgia State |
| 04 Sep 22 | r01        | New MexicoNew Mexico | 41 - 0 | MaineMaine |
| 04 Sep 22 | r01        | StanfordStanford | 41 - 10 | ColgateColgate |
| 04 Sep 22 | r01        | SyracuseSyracuse | 31 - 7 | LouisvilleLouisville |
| 04 Sep 22 | r01        | TexasTexas | 52 - 10 | Louisiana-MonroeLouisiana-Mon |
| 04 Sep 22 | r01        | Texas TechTexas Tech | 63 - 10 | Murray StateMurray State |
| 04 Sep 22 | r01        | Washington StateWashington St | 24 - 17 | IdahoIdaho |
| 04 Sep 22 | r01        | Oregon StateOregon State | 34 - 17 | Boise StateBoise State |
| 04 Sep 22 | r01        | WashingtonWashington | 45 - 20 | Kent StateKent State |
| 04 Sep 22 | r01        | HawaiiHawaii | 17 - 49 | Western KentuckyWestern Kentu |
| 04 Sep 22 | r01        | LSULSU | 23 - 24 | Florida StateFlorida State |
| 06 Sep 22 | r01        | Georgia TechGeorgia Tech | 10 - 41 | ClemsonClemson |
| |
| 09 Sep 22 | r02        | UCFUCF | 14 - 20 | LouisvilleLouisville |
| 10 Sep 22 | r02        | New MexicoNew Mexico | 14 - 31 | Boise StateBoise State |
| 10 Sep 22 | r02        | ArkansasArkansas | 44 - 30 | South CarolinaSouth Carolin |
| 10 Sep 22 | r02        | ArmyArmy | 38 - 41 | UTSAUTSA |