| 20 Mar 22 | r01        | West Coast EaglesWest Coast Ea | 80 - 107 | Gold Coast Football ClubGold Coast Fo |
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| 27 Mar 22 | r02        | North Melbourne Football North Melbour | 74 - 59 | West Coast EaglesWest Coast Ea |
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| 03 Apr 22 | r03        | West Coast EaglesWest Coast Ea | 47 - 102 | Fremantle Football ClubFremantle Foo |
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| 09 Apr 22 | r04        | Collingwood Football ClubCollingwood F | 74 - 87 | West Coast EaglesWest Coast Ea |
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| 15 Apr 22 | r05        | West Coast EaglesWest Coast Ea | 58 - 121 | Sydney SwansSydney Swans |
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| 23 Apr 22 | r06        | Port Adelaide Football ClPort Adelaide | 117 - 33 | West Coast EaglesWest Coast Ea |
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| 29 Apr 22 | r07        | West Coast EaglesWest Coast Ea | 56 - 165 | Richmond Football ClubRichmond Foot |
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| 07 May 22 | r08        | Brisbane LionsBrisbane Lion | 105 - 30 | West Coast EaglesWest Coast Ea |
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| 15 May 22 | r09        | West Coast EaglesWest Coast Ea | 38 - 112 | Melbourne Football ClubMelbourne Foo |
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| 22 May 22 | r10        | Greater Western Sydney GiGreater Weste | 138 - 86 | West Coast EaglesWest Coast Ea |
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| 28 May 22 | r11        | West Coast EaglesWest Coast Ea | 60 - 161 | Western BulldogsWestern Bulld |
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| 04 Jun 22 | r12        | Adelaide Football ClubAdelaide Foot | 88 - 57 | West Coast EaglesWest Coast Ea |
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| 18 Jun 22 | r14        | West Coast EaglesWest Coast Ea | 63 - 81 | Geelong Football ClubGeelong Footb |
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| 24 Jun 22 | r15        | West Coast EaglesWest Coast Ea | 107 - 97 | Essendon Football ClubEssendon Foot |
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| 03 Jul 22 | r16        | Richmond Football ClubRichmond Foot | 128 - 93 | West Coast EaglesWest Coast Ea |
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| 10 Jul 22 | r17        | West Coast EaglesWest Coast Ea | 53 - 116 | Carlton Football ClubCarlton Footb |
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| 17 Jul 22 | r18        | Hawthorn Football ClubHawthorn Foot | 102 - 77 | West Coast EaglesWest Coast Ea |
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| 24 Jul 22 | r19        | West Coast EaglesWest Coast Ea | 62 - 90 | St Kilda Football ClubSt Kilda Foot |
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| 31 Jul 22 | r20        | Gold Coast Football ClubGold Coast Fo | 107 - 104 | West Coast EaglesWest Coast Ea |
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| 07 Aug 22 | r21        | West Coast EaglesWest Coast Ea | 86 - 102 | Adelaide Football ClubAdelaide Foot |
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| 13 Aug 22 | r22        | Fremantle Football ClubFremantle Foo | 71 - 47 | West Coast EaglesWest Coast Ea |
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| 20 Aug 22 | r23        | Geelong Football ClubGeelong Footb | 131 - 46 | West Coast EaglesWest Coast Ea |