| 20 Mar 22 | r01        | Hawthorn Football ClubHawthorn Foot | 78 - 58 | North Melbourne Football North Melbour |
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| 27 Mar 22 | r02        | North Melbourne Football North Melbour | 74 - 59 | West Coast EaglesWest Coast Ea |
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| 02 Apr 22 | r03        | Brisbane LionsBrisbane Lion | 156 - 48 | North Melbourne Football North Melbour |
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| 09 Apr 22 | r04        | Sydney SwansSydney Swans | 86 - 75 | North Melbourne Football North Melbour |
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| 15 Apr 22 | r05        | North Melbourne Football North Melbour | 71 - 139 | Western BulldogsWestern Bulld |
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| 24 Apr 22 | r06        | North Melbourne Football North Melbour | 61 - 121 | Geelong Football ClubGeelong Footb |
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| 30 Apr 22 | r07        | Carlton Football ClubCarlton Footb | 114 - 64 | North Melbourne Football North Melbour |
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| 06 May 22 | r08        | Fremantle Football ClubFremantle Foo | 102 - 24 | North Melbourne Football North Melbour |
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| 14 May 22 | r09        | North Melbourne Football North Melbour | 46 - 115 | Port Adelaide Football ClPort Adelaide |
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| 21 May 22 | r10        | North Melbourne Football North Melbour | 53 - 100 | Melbourne Football ClubMelbourne Foo |
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| 29 May 22 | r11        | St Kilda Football ClubSt Kilda Foot | 103 - 50 | North Melbourne Football North Melbour |
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| 04 Jun 22 | r12        | Gold Coast Football ClubGold Coast Fo | 109 - 47 | North Melbourne Football North Melbour |
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| 12 Jun 22 | r13        | North Melbourne Football North Melbour | 53 - 102 | Greater Western Sydney GiGreater Weste |
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| 26 Jun 22 | r15        | North Melbourne Football North Melbour | 58 - 115 | Adelaide Football ClubAdelaide Foot |
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| 02 Jul 22 | r16        | Geelong Football ClubGeelong Footb | 144 - 32 | North Melbourne Football North Melbour |
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| 09 Jul 22 | r17        | Collingwood Football ClubCollingwood F | 88 - 81 | North Melbourne Football North Melbour |
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| 16 Jul 22 | r18        | North Melbourne Football North Melbour | 92 - 88 | Richmond Football ClubRichmond Foot |
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| 23 Jul 22 | r19        | North Melbourne Football North Melbour | 75 - 121 | Hawthorn Football ClubHawthorn Foot |
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| 31 Jul 22 | r20        | Essendon Football ClubEssendon Foot | 114 - 66 | North Melbourne Football North Melbour |
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| 07 Aug 22 | r21        | North Melbourne Football North Melbour | 88 - 126 | Sydney SwansSydney Swans |
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| 13 Aug 22 | r22        | Adelaide Football ClubAdelaide Foot | 103 - 74 | North Melbourne Football North Melbour |
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| 20 Aug 22 | r23        | North Melbourne Football North Melbour | 47 - 114 | Gold Coast Football ClubGold Coast Fo |