| 19 Mar 22 | r01        | Brisbane LionsBrisbane Lion | 80 - 69 | Port Adelaide Football ClPort Adelaide |
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| 26 Mar 22 | r02        | Essendon Football ClubEssendon Foot | 75 - 97 | Brisbane LionsBrisbane Lion |
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| 02 Apr 22 | r03        | Brisbane LionsBrisbane Lion | 156 - 48 | North Melbourne Football North Melbour |
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| 08 Apr 22 | r04        | Geelong Football ClubGeelong Footb | 80 - 70 | Brisbane LionsBrisbane Lion |
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| 14 Apr 22 | r05        | Brisbane LionsBrisbane Lion | 98 - 91 | Collingwood Football ClubCollingwood F |
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| 24 Apr 22 | r06        | Gold Coast Football ClubGold Coast Fo | 80 - 132 | Brisbane LionsBrisbane Lion |
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| 01 May 22 | r07        | Sydney SwansSydney Swans | 89 - 113 | Brisbane LionsBrisbane Lion |
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| 07 May 22 | r08        | Brisbane LionsBrisbane Lion | 105 - 30 | West Coast EaglesWest Coast Ea |
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| 14 May 22 | r09        | Adelaide Football ClubAdelaide Foot | 66 - 102 | Brisbane LionsBrisbane Lion |
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| 22 May 22 | r10        | Hawthorn Football ClubHawthorn Foot | 117 - 112 | Brisbane LionsBrisbane Lion |
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| 28 May 22 | r11        | Brisbane LionsBrisbane Lion | 110 - 96 | Greater Western Sydney GiGreater Weste |
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| 05 Jun 22 | r12        | Fremantle Football ClubFremantle Foo | 99 - 85 | Brisbane LionsBrisbane Lion |
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| 11 Jun 22 | r13        | Brisbane LionsBrisbane Lion | 78 - 57 | St Kilda Football ClubSt Kilda Foot |
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| 23 Jun 22 | r15        | Melbourne Football ClubMelbourne Foo | 117 - 53 | Brisbane LionsBrisbane Lion |
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| 30 Jun 22 | r16        | Brisbane LionsBrisbane Lion | 108 - 67 | Western BulldogsWestern Bulld |
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| 10 Jul 22 | r17        | Brisbane LionsBrisbane Lion | 90 - 100 | Essendon Football ClubEssendon Foot |
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| 16 Jul 22 | r18        | Greater Western Sydney GiGreater Weste | 59 - 99 | Brisbane LionsBrisbane Lion |
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| 23 Jul 22 | r19        | Brisbane LionsBrisbane Lion | 110 - 93 | Gold Coast Football ClubGold Coast Fo |
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| 31 Jul 22 | r20        | Richmond Football ClubRichmond Foot | 104 - 97 | Brisbane LionsBrisbane Lion |
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| 07 Aug 22 | r21        | Brisbane LionsBrisbane Lion | 114 - 81 | Carlton Football ClubCarlton Footb |
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| 12 Aug 22 | r22        | St Kilda Football ClubSt Kilda Foot | 66 - 81 | Brisbane LionsBrisbane Lion |
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| 19 Aug 22 | r23        | Brisbane LionsBrisbane Lion | 57 - 115 | Melbourne Football ClubMelbourne Foo |
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| 01 Sep 22 | Playoff        | Brisbane LionsBrisbane Lion | 106 - 104 | Richmond Football ClubRichmond Foot |
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| 09 Sep 22 | QF        | Melbourne Football ClubMelbourne Foo | 79 - 92 | Brisbane LionsBrisbane Lion |
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| 16 Sep 22 | SF        | Geelong Football ClubGeelong Footb | 120 - 49 | Brisbane LionsBrisbane Lion |