| 06 May 22 | r08        | Port Adelaide Football ClPort Adelaide | 86 - 69 | Western BulldogsWestern Bulld |
| 06 May 22 | r08        | Fremantle Football ClubFremantle Foo | 102 - 24 | North Melbourne Football North Melbour |
| 07 May 22 | r08        | Richmond Football ClubRichmond Foot | 113 - 86 | Collingwood Football ClubCollingwood F |
| 07 May 22 | r08        | Sydney SwansSydney Swans | 61 - 75 | Gold Coast Football ClubGold Coast Fo |
| 07 May 22 | r08        | Greater Western Sydney GiGreater Weste | 35 - 88 | Geelong Football ClubGeelong Footb |
| 07 May 22 | r08        | Essendon Football ClubEssendon Foot | 108 - 81 | Hawthorn Football ClubHawthorn Foot |
| 07 May 22 | r08        | Brisbane LionsBrisbane Lion | 105 - 30 | West Coast EaglesWest Coast Ea |
| 08 May 22 | r08        | Melbourne Football ClubMelbourne Foo | 93 - 55 | St Kilda Football ClubSt Kilda Foot |
| 08 May 22 | r08        | Carlton Football ClubCarlton Footb | 116 - 68 | Adelaide Football ClubAdelaide Foot |