| 20 Mar 21 | r01        | Melbourne Football ClubMelbourne Foo | 80 - 58 | Fremantle Football ClubFremantle Foo |
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| 27 Mar 21 | r02        | St Kilda Football ClubSt Kilda Foot | 73 - 91 | Melbourne Football ClubMelbourne Foo |
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| 04 Apr 21 | r03        | Greater Western Sydney GiGreater Weste | 68 - 102 | Melbourne Football ClubMelbourne Foo |
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| 11 Apr 21 | r04        | Melbourne Football ClubMelbourne Foo | 85 - 60 | Geelong Football ClubGeelong Footb |
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| 18 Apr 21 | r05        | Hawthorn Football ClubHawthorn Foot | 54 - 104 | Melbourne Football ClubMelbourne Foo |
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| 24 Apr 21 | r06        | Melbourne Football ClubMelbourne Foo | 82 - 48 | Richmond Football ClubRichmond Foot |
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| 02 May 21 | r07        | North Melbourne Football North Melbour | 73 - 103 | Melbourne Football ClubMelbourne Foo |
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| 08 May 21 | r08        | Melbourne Football ClubMelbourne Foo | 67 - 58 | Sydney SwansSydney Swans |
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| 16 May 21 | r09        | Melbourne Football ClubMelbourne Foo | 94 - 68 | Carlton Football ClubCarlton Footb |
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| 22 May 21 | r10        | Adelaide Football ClubAdelaide Foot | 96 - 95 | Melbourne Football ClubMelbourne Foo |
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| 28 May 21 | r11        | Western BulldogsWestern Bulld | 59 - 87 | Melbourne Football ClubMelbourne Foo |
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| 04 Jun 21 | r12        | Melbourne Football ClubMelbourne Foo | 97 - 75 | Brisbane LionsBrisbane Lion |
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| 14 Jun 21 | r13        | Melbourne Football ClubMelbourne Foo | 63 - 80 | Collingwood Football ClubCollingwood F |
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| 26 Jun 21 | r15        | Essendon Football ClubEssendon Foot | 57 - 68 | Melbourne Football ClubMelbourne Foo |
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| 03 Jul 21 | r16        | Melbourne Football ClubMelbourne Foo | 55 - 64 | Greater Western Sydney GiGreater Weste |
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| 10 Jul 21 | r17        | Port Adelaide Football ClPort Adelaide | 55 - 86 | Melbourne Football ClubMelbourne Foo |
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| 17 Jul 21 | r18        | Melbourne Football ClubMelbourne Foo | 79 - 79 | Hawthorn Football ClubHawthorn Foot |
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| 24 Jul 21 | r19        | Gold Coast Football ClubGold Coast Fo | P - P | Melbourne Football ClubMelbourne Foo |
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| 07 Aug 21 | r21        | West Coast EaglesWest Coast Ea | 63 - 72 | Melbourne Football ClubMelbourne Foo |
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| 14 Aug 21 | r22        | Melbourne Football ClubMelbourne Foo | 104 - 63 | Adelaide Football ClubAdelaide Foot |
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| 21 Aug 21 | r23        | Geelong Football ClubGeelong Footb | 77 - 81 | Melbourne Football ClubMelbourne Foo |
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| 28 Aug 21 | QF        | Melbourne Football ClubMelbourne Foo | 93 - 60 | Brisbane LionsBrisbane Lion |
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| 10 Sep 21 | SF        | Melbourne Football ClubMelbourne Foo | 125 - 42 | Geelong Football ClubGeelong Footb |
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| 25 Sep 21 | Final        | Melbourne Football ClubMelbourne Foo | 140 - 66 | Western BulldogsWestern Bulld |