| 21 Mar 21 | r01        | Greater Western Sydney GiGreater Weste | 78 - 86 | St Kilda Football ClubSt Kilda Foot |
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| 28 Mar 21 | r02        | Fremantle Football ClubFremantle Foo | 87 - 56 | Greater Western Sydney GiGreater Weste |
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| 04 Apr 21 | r03        | Greater Western Sydney GiGreater Weste | 68 - 102 | Melbourne Football ClubMelbourne Foo |
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| 10 Apr 21 | r04        | Collingwood Football ClubCollingwood F | 60 - 90 | Greater Western Sydney GiGreater Weste |
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| 17 Apr 21 | r05        | Sydney SwansSydney Swans | 69 - 71 | Greater Western Sydney GiGreater Weste |
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| 23 Apr 21 | r06        | Greater Western Sydney GiGreater Weste | 65 - 104 | Western BulldogsWestern Bulld |
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| 01 May 21 | r07        | Adelaide Football ClubAdelaide Foot | 39 - 106 | Greater Western Sydney GiGreater Weste |
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| 08 May 21 | r08        | Greater Western Sydney GiGreater Weste | 107 - 105 | Essendon Football ClubEssendon Foot |
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| 15 May 21 | r09        | Richmond Football ClubRichmond Foot | 87 - 83 | Greater Western Sydney GiGreater Weste |
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| 23 May 21 | r10        | Greater Western Sydney GiGreater Weste | 93 - 77 | West Coast EaglesWest Coast Ea |
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| 29 May 21 | r11        | Brisbane LionsBrisbane Lion | 129 - 65 | Greater Western Sydney GiGreater Weste |
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| 13 Jun 21 | r13        | North Melbourne Football North Melbour | 94 - 94 | Greater Western Sydney GiGreater Weste |
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| 19 Jun 21 | r14        | Greater Western Sydney GiGreater Weste | 102 - 66 | Carlton Football ClubCarlton Footb |
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| 26 Jun 21 | r15        | Greater Western Sydney GiGreater Weste | 72 - 90 | Hawthorn Football ClubHawthorn Foot |
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| 03 Jul 21 | r16        | Melbourne Football ClubMelbourne Foo | 55 - 64 | Greater Western Sydney GiGreater Weste |
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| 10 Jul 21 | r17        | Greater Western Sydney GiGreater Weste | 64 - 65 | Gold Coast Football ClubGold Coast Fo |
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| 17 Jul 21 | r18        | Greater Western Sydney GiGreater Weste | 72 - 98 | Sydney SwansSydney Swans |
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| 24 Jul 21 | r19        | Essendon Football ClubEssendon Foot | 53 - 66 | Greater Western Sydney GiGreater Weste |
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| 31 Jul 21 | r20        | Greater Western Sydney GiGreater Weste | 73 - 100 | Port Adelaide Football ClPort Adelaide |
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| 07 Aug 21 | r21        | Geelong Football ClubGeelong Footb | 65 - 84 | Greater Western Sydney GiGreater Weste |
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| 13 Aug 21 | r22        | Greater Western Sydney GiGreater Weste | 106 - 67 | Richmond Football ClubRichmond Foot |
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| 21 Aug 21 | r23        | Carlton Football ClubCarlton Footb | 75 - 89 | Greater Western Sydney GiGreater Weste |
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| 28 Aug 21 | QF        | Sydney SwansSydney Swans | 73 - 74 | Greater Western Sydney GiGreater Weste |
| 03 Sep 21 | QF        | Geelong Football ClubGeelong Footb | 103 - 68 | Greater Western Sydney GiGreater Weste |