| 20 Mar 21 |
r01        | Brisbane LionsBrisbane Lion | 94 - 125 | Sydney SwansSydney Swans |
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| 26 Mar 21 |
r02        | Geelong Football ClubGeelong Footb | 81 - 80 | Brisbane LionsBrisbane Lion |
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| 01 Apr 21 |
r03        | Collingwood Football ClubCollingwood F | 72 - 73 | Brisbane LionsBrisbane Lion |
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| 10 Apr 21 |
r04        | Western BulldogsWestern Bulld | 73 - 54 | Brisbane LionsBrisbane Lion |
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| 17 Apr 21 |
r05        | Brisbane LionsBrisbane Lion | 102 - 45 | Essendon Football ClubEssendon Foot |
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| 24 Apr 21 |
r06        | Carlton Football ClubCarlton Footb | 85 - 103 | Brisbane LionsBrisbane Lion |
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| 01 May 21 |
r07        | Brisbane LionsBrisbane Lion | 93 - 44 | Port Adelaide Football ClPort Adelaide |
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| 09 May 21 |
r08        | Brisbane LionsBrisbane Lion | 95 - 71 | Fremantle Football ClubFremantle Foo |
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| 15 May 21 |
r09        | Gold Coast Football ClubGold Coast Fo | 51 - 124 | Brisbane LionsBrisbane Lion |
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| 21 May 21 |
r10        | Brisbane LionsBrisbane Lion | 102 - 74 | Richmond Football ClubRichmond Foot |
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| 29 May 21 |
r11        | Brisbane LionsBrisbane Lion | 129 - 65 | Greater Western Sydney GiGreater Weste |
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| 04 Jun 21 |
r12        | Melbourne Football ClubMelbourne Foo | 97 - 75 | Brisbane LionsBrisbane Lion |
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| 19 Jun 21 |
r14        | North Melbourne Football North Melbour | 45 - 68 | Brisbane LionsBrisbane Lion |
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| 26 Jun 21 |
r15        | Brisbane LionsBrisbane Lion | 94 - 50 | Geelong Football ClubGeelong Footb |
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| 03 Jul 21 |
r16        | Adelaide Football ClubAdelaide Foot | 59 - 111 | Brisbane LionsBrisbane Lion |
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| 10 Jul 21 |
r17        | Brisbane LionsBrisbane Lion | 63 - 95 | St Kilda Football ClubSt Kilda Foot |
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| 17 Jul 21 |
r18        | Richmond Football ClubRichmond Foot | 106 - 86 | Brisbane LionsBrisbane Lion |
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| 24 Jul 21 |
r19        | Hawthorn Football ClubHawthorn Foot | P - P | Brisbane LionsBrisbane Lion |
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| 14 Aug 21 |
r22        | Collingwood Football ClubCollingwood F | 57 - 142 | Brisbane LionsBrisbane Lion |
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| 21 Aug 21 |
r23        | Brisbane LionsBrisbane Lion | 125 - 87 | West Coast EaglesWest Coast Ea |
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| 28 Aug 21 |
QF        | Melbourne Football ClubMelbourne Foo | 93 - 60 | Brisbane LionsBrisbane Lion |
| 04 Sep 21 |
QF        | Brisbane LionsBrisbane Lion | 78 - 79 | Western BulldogsWestern Bulld |