| 01 Jul 21 | r16        | Gold Coast Football ClubGold Coast Fo | 77 - 67 | Richmond Football ClubRichmond Foot |
| 03 Jul 21 | r16        | Collingwood Football ClubCollingwood F | 61 - 70 | St Kilda Football ClubSt Kilda Foot |
| 03 Jul 21 | r16        | Geelong Football ClubGeelong Footb | 98 - 57 | Essendon Football ClubEssendon Foot |
| 03 Jul 21 | r16        | Hawthorn Football ClubHawthorn Foot | 53 - 87 | Port Adelaide Football ClPort Adelaide |
| 03 Jul 21 | r16        | Melbourne Football ClubMelbourne Foo | 55 - 64 | Greater Western Sydney GiGreater Weste |
| 03 Jul 21 | r16        | Sydney SwansSydney Swans | 118 - 26 | West Coast EaglesWest Coast Ea |
| 03 Jul 21 | r16        | Western BulldogsWestern Bulld | 108 - 79 | North Melbourne Football North Melbour |
| 03 Jul 21 | r16        | Adelaide Football ClubAdelaide Foot | 59 - 111 | Brisbane LionsBrisbane Lion |
| 03 Jul 21 | r16        | Fremantle Football ClubFremantle Foo | 64 - 80 | Carlton Football ClubCarlton Footb |