| 21 May 21 | r10        | Brisbane LionsBrisbane Lion | 102 - 74 | Richmond Football ClubRichmond Foot |
| 22 May 21 | r10        | Carlton Football ClubCarlton Footb | 86 - 63 | Hawthorn Football ClubHawthorn Foot |
| 22 May 21 | r10        | Geelong Football ClubGeelong Footb | 91 - 57 | Gold Coast Football ClubGold Coast Fo |
| 22 May 21 | r10        | Adelaide Football ClubAdelaide Foot | 96 - 95 | Melbourne Football ClubMelbourne Foo |
| 22 May 21 | r10        | Western BulldogsWestern Bulld | 144 - 33 | St Kilda Football ClubSt Kilda Foot |
| 22 May 21 | r10        | Fremantle Football ClubFremantle Foo | 86 - 84 | Sydney SwansSydney Swans |
| 23 May 21 | r10        | Greater Western Sydney GiGreater Weste | 93 - 77 | West Coast EaglesWest Coast Ea |
| 23 May 21 | r10        | Collingwood Football ClubCollingwood F | 58 - 59 | Port Adelaide Football ClPort Adelaide |
| 23 May 21 | r10        | Essendon Football ClubEssendon Foot | 141 - 69 | North Melbourne Football North Melbour |