| 14 May 21 | r09        | St Kilda Football ClubSt Kilda Foot | 47 - 68 | Geelong Football ClubGeelong Footb |
| 15 May 21 | r09        | Sydney SwansSydney Swans | 72 - 42 | Collingwood Football ClubCollingwood F |
| 15 May 21 | r09        | Hawthorn Football ClubHawthorn Foot | 80 - 87 | North Melbourne Football North Melbour |
| 15 May 21 | r09        | Gold Coast Football ClubGold Coast Fo | 51 - 124 | Brisbane LionsBrisbane Lion |
| 15 May 21 | r09        | Richmond Football ClubRichmond Foot | 87 - 83 | Greater Western Sydney GiGreater Weste |
| 15 May 21 | r09        | Port Adelaide Football ClPort Adelaide | 77 - 96 | Western BulldogsWestern Bulld |
| 16 May 21 | r09        | Essendon Football ClubEssendon Foot | 68 - 61 | Fremantle Football ClubFremantle Foo |
| 16 May 21 | r09        | Melbourne Football ClubMelbourne Foo | 94 - 68 | Carlton Football ClubCarlton Footb |
| 16 May 21 | r09        | West Coast EaglesWest Coast Ea | 106 - 76 | Adelaide Football ClubAdelaide Foot |