| 30 Apr 21 | r07        | Richmond Football ClubRichmond Foot | 77 - 55 | Western BulldogsWestern Bulld |
| 01 May 21 | r07        | Collingwood Football ClubCollingwood F | 55 - 79 | Gold Coast Football ClubGold Coast Fo |
| 01 May 21 | r07        | Adelaide Football ClubAdelaide Foot | 39 - 106 | Greater Western Sydney GiGreater Weste |
| 01 May 21 | r07        | St Kilda Football ClubSt Kilda Foot | 128 - 59 | Hawthorn Football ClubHawthorn Foot |
| 01 May 21 | r07        | Brisbane LionsBrisbane Lion | 93 - 44 | Port Adelaide Football ClPort Adelaide |
| 01 May 21 | r07        | Sydney SwansSydney Swans | 90 - 88 | Geelong Football ClubGeelong Footb |
| 02 May 21 | r07        | North Melbourne Football North Melbour | 73 - 103 | Melbourne Football ClubMelbourne Foo |
| 02 May 21 | r07        | Essendon Football ClubEssendon Foot | 107 - 123 | Carlton Football ClubCarlton Footb |
| 02 May 21 | r07        | West Coast EaglesWest Coast Ea | 132 - 73 | Fremantle Football ClubFremantle Foo |