| 23 Apr 21 | r06        | Greater Western Sydney GiGreater Weste | 65 - 104 | Western BulldogsWestern Bulld |
| 24 Apr 21 | r06        | Geelong Football ClubGeelong Footb | 136 - 39 | West Coast EaglesWest Coast Ea |
| 24 Apr 21 | r06        | Gold Coast Football ClubGold Coast Fo | 100 - 60 | Sydney SwansSydney Swans |
| 24 Apr 21 | r06        | Carlton Football ClubCarlton Footb | 85 - 103 | Brisbane LionsBrisbane Lion |
| 24 Apr 21 | r06        | Melbourne Football ClubMelbourne Foo | 82 - 48 | Richmond Football ClubRichmond Foot |
| 24 Apr 21 | r06        | Fremantle Football ClubFremantle Foo | 99 - 48 | North Melbourne Football North Melbour |
| 25 Apr 21 | r06        | Hawthorn Football ClubHawthorn Foot | 102 - 99 | Adelaide Football ClubAdelaide Foot |
| 25 Apr 21 | r06        | Collingwood Football ClubCollingwood F | 85 - 109 | Essendon Football ClubEssendon Foot |
| 25 Apr 21 | r06        | Port Adelaide Football ClPort Adelaide | 93 - 39 | St Kilda Football ClubSt Kilda Foot |