| 08 Apr 21 | r04        | Sydney SwansSydney Swans | 83 - 80 | Essendon Football ClubEssendon Foot |
| 09 Apr 21 | r04        | Port Adelaide Football ClPort Adelaide | 79 - 77 | Richmond Football ClubRichmond Foot |
| 10 Apr 21 | r04        | Western BulldogsWestern Bulld | 73 - 54 | Brisbane LionsBrisbane Lion |
| 10 Apr 21 | r04        | St Kilda Football ClubSt Kilda Foot | 102 - 82 | West Coast EaglesWest Coast Ea |
| 10 Apr 21 | r04        | Collingwood Football ClubCollingwood F | 60 - 90 | Greater Western Sydney GiGreater Weste |
| 10 Apr 21 | r04        | Gold Coast Football ClubGold Coast Fo | 59 - 70 | Carlton Football ClubCarlton Footb |
| 11 Apr 21 | r04        | North Melbourne Football North Melbour | 68 - 109 | Adelaide Football ClubAdelaide Foot |
| 11 Apr 21 | r04        | Melbourne Football ClubMelbourne Foo | 85 - 60 | Geelong Football ClubGeelong Footb |
| 11 Apr 21 | r04        | Fremantle Football ClubFremantle Foo | 96 - 81 | Hawthorn Football ClubHawthorn Foot |