| 27 Mar 10 | r00        | Brisbane LionsBrisbane Lion | 16 - 12 | West Coast EaglesWest Coast Ea |
| 01 Apr 10 | r00        | Brisbane LionsBrisbane Lion | 16 - 12 | Carlton Football ClubCarlton Footb |
| 10 Apr 10 | r00        | Port Adelaide Football ClPort Adelaide | 11 - 16 | Brisbane LionsBrisbane Lion |
| 17 Apr 10 | r00        | Brisbane LionsBrisbane Lion | 13 - 12 | Western BulldogsWestern Bulld |
| 24 Apr 10 | r00        | Melbourne Football ClubMelbourne Foo | 15 - 7 | Brisbane LionsBrisbane Lion |
| 01 May 10 | r00        | Sydney SwansSydney Swans | 16 - 13 | Brisbane LionsBrisbane Lion |
| 08 May 10 | r00        | Brisbane LionsBrisbane Lion | 15 - 15 | Fremantle Football ClubFremantle Foo |
| 15 May 10 | r00        | Brisbane LionsBrisbane Lion | 10 - 24 | Geelong Football ClubGeelong Footb |
| 23 May 10 | r00        | Adelaide Football ClubAdelaide Foot | 13 - 11 | Brisbane LionsBrisbane Lion |
| 29 May 10 | r00        | Brisbane LionsBrisbane Lion | 13 - 11 | Collingwood Football ClubCollingwood F |
| 05 Jun 10 | r00        | North Melbourne Football North Melbour | 12 - 13 | Brisbane LionsBrisbane Lion |
| 13 Jun 10 | r00        | Western BulldogsWestern Bulld | 17 - 8 | Brisbane LionsBrisbane Lion |
| 19 Jun 10 | r00        | Brisbane LionsBrisbane Lion | 12 - 15 | Richmond Football ClubRichmond Foot |
| 01 Jul 10 | r00        | Carlton Football ClubCarlton Footb | 18 - 9 | Brisbane LionsBrisbane Lion |
| 10 Jul 10 | r00        | Brisbane LionsBrisbane Lion | 10 - 11 | St Kilda Football ClubSt Kilda Foot |
| 17 Jul 10 | r00        | Hawthorn Football ClubHawthorn Foot | 17 - 7 | Brisbane LionsBrisbane Lion |
| 24 Jul 10 | r00        | Geelong Football ClubGeelong Footb | 19 - 9 | Brisbane LionsBrisbane Lion |
| 31 Jul 10 | r00        | Brisbane LionsBrisbane Lion | 9 - 11 | Melbourne Football ClubMelbourne Foo |
| 07 Aug 10 | r00        | West Coast EaglesWest Coast Ea | 9 - 10 | Brisbane LionsBrisbane Lion |
| 15 Aug 10 | r00        | Brisbane LionsBrisbane Lion | 13 - 15 | Adelaide Football ClubAdelaide Foot |
| 22 Aug 10 | r00        | Essendon Football ClubEssendon Foot | 10 - 14 | Brisbane LionsBrisbane Lion |
| 28 Aug 10 | r00        | Brisbane LionsBrisbane Lion | 10 - 16 | Sydney SwansSydney Swans |