| 08 Mar 25 | r01        | Manly Sea EaglesManly Sea Eag | 42 - 12 | North Queensland CowboysNorth Queensl |
| |
| 15 Mar 25 | r02        | North Queensland CowboysNorth Queensl | 12 - 36 | Cronulla SharksCronulla Shar |
| |
| 21 Mar 25 | r03        | Brisbane BroncosBrisbane Bron | 26 - 16 | North Queensland CowboysNorth Queensl |
| |
| 29 Mar 25 | r04        | North Queensland CowboysNorth Queensl | 30 - 20 | Canberra RaidersCanberra Raid |
| |
| 04 Apr 25 | r05        | Penrith PanthersPenrith Panth | 18 - 22 | North Queensland CowboysNorth Queensl |
| |
| 12 Apr 25 | r06        | South Sydney RabbitohsSouth Sydney | 16 - 24 | North Queensland CowboysNorth Queensl |
| |
| 26 Apr 25 | r08        | North Queensland CowboysNorth Queensl | 50 - 18 | Gold Coast TitansGold Coast Ti |
| |
| 03 May 25 | r09        | New Zealand WarriorsNew Zealand W | 30 - 26 | North Queensland CowboysNorth Queensl |
| |
| 10 May 25 | r10        | North Queensland CowboysNorth Queensl | 30 - 30 | Penrith PanthersPenrith Panth |
| |
| 17 May 25 | r11        | North Queensland CowboysNorth Queensl | 6 - 24 | Manly Sea EaglesManly Sea Eag |
| |
| 31 May 25 | r13        | North Queensland CowboysNorth Queensl | 32 - 28 | Wests TigersWests Tigers |
| |
| 06 Jun 25 | r14        | Melbourne StormMelbourne Sto | 38 - 14 | North Queensland CowboysNorth Queensl |
| |
| 14 Jun 25 | r15        | North Queensland CowboysNorth Queensl | 4 - 58 | DolphinsDolphins |
| |
| 22 Jun 25 | r16        | Sydney RoostersSydney Rooste | 42 - 8 | North Queensland CowboysNorth Queensl |
| |
| 29 Jun 25 | r17        | Gold Coast TitansGold Coast Ti | 24 - 30 | North Queensland CowboysNorth Queensl |
| |
| 05 Jul 25 | r18        | North Queensland CowboysNorth Queensl | 20 - 26 | Melbourne StormMelbourne Sto |
| |
| 12 Jul 25 | r19        | North Queensland CowboysNorth Queensl | 8 - 12 | Canterbury Bankstown BullCanterbury Ba |
| |
| 17 Jul 25 | r20        | DolphinsDolphins | 43 - 24 | North Queensland CowboysNorth Queensl |
| |
| 25 Jul 25 | r21        | North Queensland CowboysNorth Queensl | 38 - 32 | St. George Illawara DragoSt. George Il |
| |
| 03 Aug 25 | r22        | Cronulla SharksCronulla Shar | 32 - 12 | North Queensland CowboysNorth Queensl |
| |
| 10 Aug 25 | r23        | Parramatta EelsParramatta Ee | 19 - 18 | North Queensland CowboysNorth Queensl |
| |
| 17 Aug 25 | r24        | North Queensland CowboysNorth Queensl | 38 - 4 | Newcastle KnightsNewcastle Kni |
| |
| 24 Aug 25 | r25        | Wests TigersWests Tigers | 28 - 34 | North Queensland CowboysNorth Queensl |
| |
| 30 Aug 25 | r26        | North Queensland CowboysNorth Queensl | 30 - 38 | Brisbane BroncosBrisbane Bron |