| 13 Mar 21 | r01        | Penrith PanthersPenrith Panth | 24 - 0 | North Queensland CowboysNorth Queensl |
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| 20 Mar 21 | r02        | North Queensland CowboysNorth Queensl | 18 - 25 | St. George Illawara DragoSt. George Il |
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| 28 Mar 21 | r03        | North Queensland CowboysNorth Queensl | 8 - 44 | Gold Coast TitansGold Coast Ti |
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| 03 Apr 21 | r04        | Cronulla SharksCronulla Shar | 48 - 10 | North Queensland CowboysNorth Queensl |
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| 11 Apr 21 | r05        | Wests TigersWests Tigers | 30 - 34 | North Queensland CowboysNorth Queensl |
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| 18 Apr 21 | r06        | North Queensland CowboysNorth Queensl | 30 - 18 | Canterbury Bankstown BullCanterbury Ba |
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| 24 Apr 21 | r07        | North Queensland CowboysNorth Queensl | 26 - 24 | Canberra RaidersCanberra Raid |
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| 02 May 21 | r08        | New Zealand WarriorsNew Zealand W | 24 - 20 | North Queensland CowboysNorth Queensl |
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| 08 May 21 | r09        | North Queensland CowboysNorth Queensl | 19 - 18 | Brisbane BroncosBrisbane Bron |
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| 15 May 21 | r10        | Sydney RoostersSydney Rooste | 30 - 16 | North Queensland CowboysNorth Queensl |
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| 20 May 21 | r11        | North Queensland CowboysNorth Queensl | 36 - 20 | Newcastle Knights Newcastle Kni |
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| 28 May 21 | r12        | North Queensland CowboysNorth Queensl | 29 - 28 | New Zealand WarriorsNew Zealand W |
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| 11 Jun 21 | r14        | Manly Sea EaglesManly Sea Eag | 50 - 18 | North Queensland CowboysNorth Queensl |
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| 18 Jun 21 | r15        | North Queensland CowboysNorth Queensl | 24 - 26 | Cronulla SharksCronulla Shar |
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| 03 Jul 21 | r16        | Newcastle Knights Newcastle Kni | 38 - 0 | North Queensland CowboysNorth Queensl |
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| 09 Jul 21 | r17        | South Sydney RabbitohsSouth Sydney | 46 - 18 | North Queensland CowboysNorth Queensl |
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| 17 Jul 21 | r18        | North Queensland CowboysNorth Queensl | 18 - 34 | Sydney RoostersSydney Rooste |
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| 23 Jul 21 | r19        | North Queensland CowboysNorth Queensl | 16 - 20 | Melbourne StormMelbourne Sto |
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| 30 Jul 21 | r20        | Brisbane BroncosBrisbane Bron | 37 - 18 | North Queensland CowboysNorth Queensl |
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| 08 Aug 21 | r21        | Gold Coast TitansGold Coast Ti | 36 - 14 | North Queensland CowboysNorth Queensl |
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| 14 Aug 21 | r22        | North Queensland CowboysNorth Queensl | 16 - 24 | Wests TigersWests Tigers |
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| 21 Aug 21 | r23        | Parramatta EelsParramatta Ee | 32 - 16 | North Queensland CowboysNorth Queensl |
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| 28 Aug 21 | r24        | St. George Illawara DragoSt. George Il | 26 - 38 | North Queensland CowboysNorth Queensl |
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| 04 Sep 21 | r25        | North Queensland CowboysNorth Queensl | 18 - 46 | Manly Sea EaglesManly Sea Eag |