| 11 Mar 21 | r01        | Melbourne StormMelbourne Sto | 26 - 18 | South Sydney RabbitohsSouth Sydney |
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| 18 Mar 21 | r02        | Parramatta EelsParramatta Ee | 16 - 12 | Melbourne StormMelbourne Sto |
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| 25 Mar 21 | r03        | Penrith PanthersPenrith Panth | 12 - 10 | Melbourne StormMelbourne Sto |
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| 02 Apr 21 | r04        | Melbourne StormMelbourne Sto | 40 - 6 | Brisbane BroncosBrisbane Bron |
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| 10 Apr 21 | r05        | Canterbury Bankstown BullCanterbury Ba | 18 - 52 | Melbourne StormMelbourne Sto |
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| 16 Apr 21 | r06        | Melbourne StormMelbourne Sto | 20 - 4 | Sydney RoostersSydney Rooste |
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| 25 Apr 21 | r07        | Melbourne StormMelbourne Sto | 42 - 20 | New Zealand WarriorsNew Zealand W |
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| 30 Apr 21 | r08        | Melbourne StormMelbourne Sto | 40 - 14 | Cronulla SharksCronulla Shar |
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| 06 May 21 | r09        | South Sydney RabbitohsSouth Sydney | 0 - 50 | Melbourne StormMelbourne Sto |
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| 16 May 21 | r10        | Melbourne StormMelbourne Sto | 44 - 18 | St. George Illawara DragoSt. George Il |
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| 22 May 21 | r11        | Canberra RaidersCanberra Raid | 10 - 34 | Melbourne StormMelbourne Sto |
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| 27 May 21 | r12        | Brisbane BroncosBrisbane Bron | 12 - 40 | Melbourne StormMelbourne Sto |
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| 05 Jun 21 | r13        | Melbourne StormMelbourne Sto | 20 - 14 | Gold Coast TitansGold Coast Ti |
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| 13 Jun 21 | r14        | New Zealand WarriorsNew Zealand W | 16 - 42 | Melbourne StormMelbourne Sto |
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| 19 Jun 21 | r15        | Melbourne StormMelbourne Sto | 66 - 16 | Wests TigersWests Tigers |
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| 01 Jul 21 | r16        | Sydney RoostersSydney Rooste | 0 - 46 | Melbourne StormMelbourne Sto |
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| 17 Jul 21 | r18        | Melbourne StormMelbourne Sto | 48 - 4 | Newcastle Knights Newcastle Kni |
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| 23 Jul 21 | r19        | North Queensland CowboysNorth Queensl | 16 - 20 | Melbourne StormMelbourne Sto |
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| 31 Jul 21 | r20        | Melbourne StormMelbourne Sto | 37 - 10 | Penrith PanthersPenrith Panth |
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| 07 Aug 21 | r21        | Manly Sea EaglesManly Sea Eag | 18 - 28 | Melbourne StormMelbourne Sto |
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| 12 Aug 21 | r22        | Melbourne StormMelbourne Sto | 26 - 16 | Canberra RaidersCanberra Raid |
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| 19 Aug 21 | r23        | Gold Coast TitansGold Coast Ti | 20 - 34 | Melbourne StormMelbourne Sto |
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| 28 Aug 21 | r24        | Melbourne StormMelbourne Sto | 10 - 22 | Parramatta EelsParramatta Ee |
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| 03 Sep 21 | r25        | Cronulla SharksCronulla Shar | 16 - 28 | Melbourne StormMelbourne Sto |
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| 10 Sep 21 | Playoff        | Melbourne StormMelbourne Sto | 40 - 12 | Manly Sea EaglesManly Sea Eag |
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| 25 Sep 21 | SF        | Melbourne StormMelbourne Sto | 6 - 10 | Penrith PanthersPenrith Panth |